Gene/Proteome Database (LMPD)

LMPD ID
LMP007176
Gene ID
854310
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
succinate--CoA ligase (GDP-forming) subunit alpha
Gene Symbol
LSC1
Synonyms
-
Alternate Names
succinate--CoA ligase (GDP-forming) subunit alpha
Chromosome
XV
EC Number
6.2.1.5

Proteins

succinate--CoA ligase (GDP-forming) subunit alpha
Refseq ID NP_014785
Protein GI 398365347
UniProt ID P53598
mRNA ID NM_001183561
Length 329
RefSeq Status PROVISIONAL
MLRSTVSKASLKICRHFHRESIPYDKTIKNLLLPKDTKVIFQGFTGKQGTFHASISQEYGTNVVGGTNPKKAGQTHLGQPVFASVKDAIKETGATASAIFVPPPIAAAAIKESIEAEIPLAVCITEGIPQHDMLYIAEMLQTQDKTRLVGPNCPGIINPATKVRIGIQPPKIFQAGKIGIISRSGTLTYEAVQQTTKTDLGQSLVIGMGGDAFPGTDFIDALKLFLEDETTEGIIMLGEIGGKAEIEAAQFLKEYNFSRSKPMPVASFIAGTVAGQMKGVRMGHSGAIVEGSGTDAESKKQALRDVGVAVVESPGYLGQALLDQFAKFK

Gene Information

Entrez Gene ID
854310
Gene Name
succinate--CoA ligase (GDP-forming) subunit alpha
Gene Symbol
LSC1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042645 IDA:SGD C mitochondrial nucleoid
GO:0005739 IDA:SGD C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003878 IEA:InterPro F ATP citrate synthase activity
GO:0005525 IEA:UniProtKB-KW F GTP binding
GO:0048037 IEA:InterPro F cofactor binding
GO:0004775 IDA:SGD F succinate-CoA ligase (ADP-forming) activity
GO:0006104 IDA:SGD P succinyl-CoA metabolic process
GO:0006099 TAS:SGD P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
sce01200 Carbon metabolism
sce00020 Citrate cycle (TCA cycle)
sce_M00009 Citrate cycle (TCA cycle, Krebs cycle)

BIOCYC Pathway Links

BIOCYC Pathway ID Description
TCA-EUK-PWY-YEAST TCA cycle, aerobic respiration

Domain Information

InterPro Annotations

Accession Description
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site
IPR003781 CoA-binding
IPR016040 NAD(P)-binding domain
IPR005810 Succinyl-CoA ligase, alpha subunit
IPR016102 Succinyl-CoA synthetase-like

UniProt Annotations

Entry Information

Gene Name
succinate--CoA ligase (GDP-forming) subunit alpha
Protein Entry
SUCA_YEAST
UniProt ID
P53598
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. {ECO:0000269|PubMed:9874242}.
Induction Induced during growth on nonfermentable carbon sources and repressed during growth on glucose. {ECO:0000269|PubMed:9874242}.
Miscellaneous Present with 18400 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Similarity Belongs to the succinate/malate CoA ligase alpha subunit family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}.
Subunit Heterodimer of an alpha and a beta subunit. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007176 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398365347 RefSeq NP_014785 329 succinate--CoA ligase (GDP-forming) subunit alpha

Identical Sequences to LMP007176 proteins

Reference Database Accession Length Protein Name
GI:398365347 GenBank AEQ84688.1 329 Sequence 182 from patent US 8039587
GI:398365347 GenBank AEU53551.1 329 Sequence 182 from patent US 8062891
GI:398365347 GenBank EIW07571.1 329 Lsc1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:398365347 GenBank AGO72504.1 329 Sequence 182 from patent US 8470972
GI:398365347 GenBank AGU32495.1 329 Sequence 182 from patent US 8507277
GI:398365347 GenBank AGX48399.1 329 Sequence 182 from patent US 8541550

Related Sequences to LMP007176 proteins

Reference Database Accession Length Protein Name
GI:398365347 GenBank EDV10733.1 329 succinyl-CoA ligase alpha-chain, mitochondrial precursor [Saccharomyces cerevisiae RM11-1a]
GI:398365347 GenBank EDZ69263.1 329 YOR142Wp-like protein [Saccharomyces cerevisiae AWRI1631]
GI:398365347 GenBank EGA72917.1 329 Lsc1p [Saccharomyces cerevisiae AWRI796]
GI:398365347 GenBank EGA80841.1 329 Lsc1p [Saccharomyces cerevisiae Lalvin QA23]
GI:398365347 GenBank EGA84645.1 329 Lsc1p [Saccharomyces cerevisiae VL3]
GI:398365347 GenBank EWH15971.1 329 Lsc1p [Saccharomyces cerevisiae P283]