Gene/Proteome Database (LMPD)

LMPD ID
LMP007171
Gene ID
853345
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
1-phosphatidylinositol 4-kinase LSB6
Gene Symbol
LSB6
Synonyms
-
Alternate Names
1-phosphatidylinositol 4-kinase LSB6
Chromosome
X
EC Number
2.7.1.67

Proteins

1-phosphatidylinositol 4-kinase LSB6
Refseq ID NP_012435
Protein GI 6322361
UniProt ID P42951
mRNA ID NM_001181533
Length 607
RefSeq Status PROVISIONAL
MSNEAYQHDHTVNPHQKIVVNSYDWLQFRDEQDHCKSKNPITHASPGVGSNAQNSDIAEAPQVFHPSYQSLVNVPSESPRPDQTSGSNPAVGLLHNAEDKASGQEEEGSQYEIQYSVFRPLHAYPTKGLAYEQLRRKEEQEQRENFNHLVSDCIEAVETFGRELERIQTGSSGSYFVYGTRADESVPVGVFKPKDEEPYGPFSPKWTKWAHRTFFPCLFGRSCLIPNLGYICESAASLLDRRLETHLVPYTDTASIESFNFYDNRKKWVLGYNLQKKKQKKLGSFQLFLKEYINADEFFHKYPLPGMYSDVKHSFHRKSSGEDINHKPETTRNLTDETEPSKQINSSPISTESEENSKFEWTESSLSQFRLELEKLIILDYIMRNTDRGLDNWMVKLIKLSNNKWRLKLAAIDNGLSFPWKHPDEWRLYPYGWLYLPLQLLAKPFSEQMRSHFLPILTSTNWWEESYQEFLALFSRDQDFNVRMWKKQWAVLKGQAFNVVETLKDPRQGPLELVRRTRCQVIDEKMQVPCCPPPVSIFKNAIDEPIGSYSTSPMVLPSTPSTIPFHAHNQSNSNPVYYDSTLHPFANKTVIAERLQIVNSTPVFTWC

Gene Information

Entrez Gene ID
853345
Gene Name
1-phosphatidylinositol 4-kinase LSB6
Gene Symbol
LSB6
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000329 IDA:SGD C fungal-type vacuole membrane
GO:0005886 IDA:SGD C plasma membrane
GO:0004430 IDA:SGD F 1-phosphatidylinositol 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0046854 IDA:SGD P phosphatidylinositol phosphorylation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3O-242 phosphatidylinositol phosphate biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5618614 Synthesis of PIPs at the Golgi membrane
5618615 Synthesis of PIPs at the early endosome membrane
5618610 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site

UniProt Annotations

Entry Information

Gene Name
1-phosphatidylinositol 4-kinase LSB6
Protein Entry
LSB6_YEAST
UniProt ID
P42951
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. {ECO:0000269|PubMed:12361950, ECO:0000269|PubMed:12523934}.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:12361950}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:12361950};
Function May play a role in endocytic and/or exocytic pathways. {ECO:0000269|PubMed:12523934}.
Miscellaneous Present with 56 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the PI3/PI4-kinase family. {ECO:0000305}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000305}.
Subcellular Location Cell membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=Located at both the plasma and vacuolar membrane.
Subunit Interacts with LAS17. {ECO:0000269|PubMed:12523934}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007171 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322361 RefSeq NP_012435 607 1-phosphatidylinositol 4-kinase LSB6

Identical Sequences to LMP007171 proteins

Reference Database Accession Length Protein Name
GI:6322361 GenBank EIW09431.1 607 Lsb6p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6322361 GenBank EWG85030.1 607 Lsb6p [Saccharomyces cerevisiae R008]
GI:6322361 GenBank EWG90311.1 607 Lsb6p [Saccharomyces cerevisiae P301]
GI:6322361 GenBank EWG95034.1 607 Lsb6p [Saccharomyces cerevisiae R103]
GI:6322361 GenBank EWH17781.1 607 Lsb6p [Saccharomyces cerevisiae P283]
GI:6322361 gnl McCuskerlabDuke 607 Lsb6p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007171 proteins

Reference Database Accession Length Protein Name
GI:6322361 DBBJ GAA24261.1 607 K7_Lsb6p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6322361 EMBL CAY80629.1 607 Lsb6p [Saccharomyces cerevisiae EC1118]
GI:6322361 GenBank EDN63477.1 607 Las17p binding protein [Saccharomyces cerevisiae YJM789]
GI:6322361 GenBank EGA61637.1 607 Lsb6p [Saccharomyces cerevisiae FostersO]
GI:6322361 GenBank EGA86256.1 607 Lsb6p [Saccharomyces cerevisiae VL3]
GI:6322361 GenBank EHN06464.1 607 Lsb6p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]