Gene/Proteome Database (LMPD)

LMPD ID
LMP007161
Gene ID
851096
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Csr1p
Gene Symbol
CSR1
Synonyms
SFH2
Alternate Names
Csr1p
Chromosome
XII

Proteins

Csr1p
Refseq ID NP_013484
Protein GI 398366045
UniProt ID Q06705
mRNA ID NM_001182269
Length 408
RefSeq Status PROVISIONAL
MSFDRQLTEDQEVVLKQIWTHLFHLWQVPVDGTHIFPNNSLHSSSTPAKKKKSSWFSKLQSSDHTQDSSEAAEAAHLYEKGKIHKALANLDPQTTKKQFWHDIKNETPDATILKFIRARKWNADKTIAMLGHDLYWRKDTINKIINGGERAVYENNETGVIKNLELQKATIQGYDNDMRPVILVRPRLHHSSDQTEQELEKFSLLVIEQSKLFFKENYPASTTILFDLNGFSMSNMDYAPVKFLITCFEAHYPESLGHLLIHKAPWIFNPIWNIIKNWLDPVVASKIVFTKNIDELHKFIQPQYIPRYLGGENDNDLDHYTPPDGSLDVHLKDTETRAMIEKEREELVEQFLTVTAQWIEHQPLNDPAYIQLQEKRVQLSTALCENYSKLDPYIRSRSVYDYNGSLKV

Gene Information

Entrez Gene ID
851096
Gene Name
Csr1p
Gene Symbol
CSR1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:SGD C cytosol
GO:0005768 IDA:SGD C endosome
GO:0005811 IDA:SGD C lipid particle
GO:0008526 IDA:SGD F phosphatidylinositol transporter activity
GO:0043001 IGI:SGD P Golgi to plasma membrane protein transport
GO:0006893 IGI:SGD P Golgi to plasma membrane transport
GO:0045717 IDA:SGD P negative regulation of fatty acid biosynthetic process
GO:1901352 IGI:SGD P negative regulation of phosphatidylglycerol biosynthetic process
GO:0046488 IGI:SGD P phosphatidylinositol metabolic process
GO:0009395 IEA:UniProtKB-KW P phospholipid catabolic process
GO:0015914 IDA:SGD P phospholipid transport
GO:2001247 IGI:SGD P positive regulation of phosphatidylcholine biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR001251 CRAL-TRIO domain
IPR011074 CRAL/TRIO, N-terminal domain

UniProt Annotations

Entry Information

Gene Name
Csr1p
Protein Entry
CSR1_YEAST
UniProt ID
Q06705
Species
Yeast (S288c)

Comments

Comment Type Description
Function Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Activates SPO14/PLD1 (phospholipase D1) by stimulating phosphoinositide synthesis via the STT4 PtdIns 4-kinase. Modulates ArfGAP function through effects on SPO14 activity. Inhibits phosphatidylcholine degradation by PLB1 (phospholipase B1). May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress. {ECO:0000269|PubMed:10679005, ECO:0000269|PubMed:10848624, ECO:0000269|PubMed:12435498, ECO:0000269|PubMed:12824182, ECO:0000269|PubMed:12869188, ECO:0000269|PubMed:16126894, ECO:0000269|PubMed:16262726}.
Miscellaneous Present with 9600 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the PITP family. {ECO:0000305}.
Similarity Contains 1 CRAL-TRIO domain. {ECO:0000255|PROSITE- ProRule:PRU00056}.
Subcellular Location Cytoplasm. Endosome.
Subunit Forms a complex with 2 TSA2 subunits. Binds phosphatidylinositol (PtdIns).

Identical and Related Proteins

Unique RefSeq proteins for LMP007161 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398366045 RefSeq NP_013484 408 Csr1p

Identical Sequences to LMP007161 proteins

Reference Database Accession Length Protein Name
GI:398366045 GenBank EIW08978.1 408 Csr1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:398366045 GenBank EWG84582.1 408 Csr1p [Saccharomyces cerevisiae R008]
GI:398366045 GenBank EWG89735.1 408 Csr1p [Saccharomyces cerevisiae P301]
GI:398366045 GenBank EWG94516.1 408 Csr1p [Saccharomyces cerevisiae R103]
GI:398366045 GenBank EWH16976.1 408 Csr1p [Saccharomyces cerevisiae P283]
GI:398366045 gnl McCuskerlabDuke 408 Csr1p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007161 proteins

Reference Database Accession Length Protein Name
GI:398366045 EMBL CAY81606.1 408 Csr1p [Saccharomyces cerevisiae EC1118]
GI:398366045 EMBL CBX86431.1 408 unnamed protein product [Saccharomyces cerevisiae]
GI:398366045 GenBank AAT92884.1 408 YLR380W [Saccharomyces cerevisiae]
GI:398366045 GenBank EDZ70429.1 408 YLR380Wp-like protein [Saccharomyces cerevisiae AWRI1631]
GI:398366045 GenBank EGA77673.1 408 Csr1p [Saccharomyces cerevisiae Vin13]
GI:398366045 GenBank EHN01082.1 409 Csr1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]