Gene/Proteome Database (LMPD)

LMPD ID
LMP007130
Gene ID
853964
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Tgl4p
Gene Symbol
TGL4
Synonyms
STC1
Alternate Names
Tgl4p
Chromosome
XI
EC Number
3.1.1.3

Proteins

Tgl4p
Refseq ID NP_013015
Protein GI 6322942
UniProt ID P36165
mRNA ID NM_001179879
Length 910
RefSeq Status PROVISIONAL
MSSKISDLTSTQNKPLLVTQQLIEKYYEQILGTSQNIIPILNPKNKFIRPSKDNSDVERVEEDAGKRLQTGKNKTTNKVNFNLDTGNEDKLDDDQETVTENENNDIEMVETDEGEDERQGSSLASKCKSFLYNVFVGNYERDILIDKVCSQKQHAMSFEEWCSAGARLDDLTGKTEWKQKLESPLYDYKLIKDLTSRMREERLNRNYAQLLYIIRTNWVRNLGNMGNVNLYRHSHVGTKYLIDEYMMESRLALESLMESDLDDSYLLGILQQTRRNIGRTALVLSGGGTFGLFHIGVLGTLFELDLLPRVISGSSAGAIVASILSVHHKEEIPVLLNHILDKEFNIFKDDKQKSESENLLIKISRFFKNGTWFDNKHLVNTMIEFLGDLTFREAYNRTGKILNITVSPASLFEQPRLLNNLTAPNVLIWSAVCASCSLPGIFPSSPLYEKDPKTGERKPWTGSSSVKFVDGSVDNDLPISRLSEMFNVDHIIACQVNIHVFPFLKLSLSCVGGEIEDEFSARLKQNLSSIYNFMANEAIHILEIGSEMGIAKNALTKLRSVLSQQYSGDITILPDMCMLFRIKELLSNPTKEFLLREITNGAKATWPKVSIIQNHCGQEFALDKAISYIKGRMIVTSSLKTPFQFADSVIGLIKAPEQTSDESKNPENSTLLTRTPTKGDNHISNVLDDNLLESESTNSLLLLRENASTYGRSPSGFRPRYSITSASLNPRHQRRKSDTISTSRRPAKSFSFSVASPTSRMLRQSSKINGHPPPILQKKTSMGRLMFPMDAKTYDPESHELIPHSASIETPAMVDKKLHFGRKSRYLRHMNKKWVSSSNILYTDSDKEDHPTLRLISNFDSDAMIHSDLAGNFRRHSIDGRPPSQATKSSPFRSRPSSSTQHKSTTSFTQ

Gene Information

Entrez Gene ID
853964
Gene Name
Tgl4p
Gene Symbol
TGL4
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005811 IDA:SGD C lipid particle
GO:0047499 IDA:SGD F calcium-independent phospholipase A2 activity
GO:0042171 IDA:SGD F lysophosphatidic acid acyltransferase activity
GO:0004771 IDA:SGD F sterol esterase activity
GO:0004806 IDA:SGD F triglyceride lipase activity
GO:0007114 IMP:SGD P cell budding
GO:0006644 IMP:SGD P phospholipid metabolic process
GO:0030435 IEA:UniProtKB-KW P sporulation resulting in formation of a cellular spore
GO:0019433 IMP:SGD P triglyceride catabolic process
GO:0006642 IDA:SGD P triglyceride mobilization

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7417 phospholipid remodeling (phosphatidate)
PWY-7416 phospholipid remodeling (phosphatidylcholine)
PWY-7409 phospholipid remodeling (phosphatidylethanolamine)
PWY-7411 superpathway phosphatidate biosynthesis (yeast)

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR002641 Patatin/Phospholipase A2-related
IPR021771 Triacylglycerol lipase

UniProt Annotations

Entry Information

Gene Name
Tgl4p
Protein Entry
TGL4_YEAST
UniProt ID
P36165
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Function Releases specific fatty acids from neutral lipid triacylglycerols (TAG) thereby supplying fatty acids to a general acylation process. May have a specific role in sporulation. {ECO:0000269|PubMed:16135509}.
Interaction Q12168:ACF2; NbExp=1; IntAct=EBI-26531, EBI-32973; P41543:OST1; NbExp=1; IntAct=EBI-26531, EBI-12651; P87284:PMP3; NbExp=1; IntAct=EBI-26531, EBI-13555; P26570:PPZ1; NbExp=1; IntAct=EBI-26531, EBI-13807; P33203:PRP40; NbExp=1; IntAct=EBI-26531, EBI-701; P38800:YHR080C; NbExp=1; IntAct=EBI-26531, EBI-24597;
Miscellaneous Present with 195 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Contains 1 patatin domain. {ECO:0000305}.
Subcellular Location Lipid droplet. Membrane; Multi-pass membrane protein. Note=Lipid particle.

Identical and Related Proteins

Unique RefSeq proteins for LMP007130 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322942 RefSeq NP_013015 910 Tgl4p

Identical Sequences to LMP007130 proteins

Reference Database Accession Length Protein Name
GI:6322942 GenBank EIW09331.1 910 Tgl4p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6322942 GenBank EWG84920.1 910 Tgl4p [Saccharomyces cerevisiae R008]
GI:6322942 GenBank EWG90200.1 910 Tgl4p [Saccharomyces cerevisiae P301]
GI:6322942 GenBank EWG94797.1 910 Tgl4p [Saccharomyces cerevisiae R103]
GI:6322942 GenBank EWH17443.1 910 Tgl4p [Saccharomyces cerevisiae P283]
GI:6322942 gnl McCuskerlabDuke 910 Tgl4p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007130 proteins

Reference Database Accession Length Protein Name
GI:6322942 DBBJ GAA24809.1 910 K7_Tgl4p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6322942 GenBank EDN59991.1 910 triacylglycerol lipase [Saccharomyces cerevisiae YJM789]
GI:6322942 GenBank EEU04546.1 910 Tgl4p [Saccharomyces cerevisiae JAY291]
GI:6322942 GenBank EGA74067.1 954 Tgl4p [Saccharomyces cerevisiae AWRI796]
GI:6322942 GenBank EJT42032.1 908 TGL4-like protein [Saccharomyces kudriavzevii IFO 1802]
GI:6322942 RefSeq XP_003679572.1 905 hypothetical protein TDEL_0B02320 [Torulaspora delbrueckii]