LIPID MAPS

LMPD ID

LMP007124

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

phosphatidylinositol-3-phosphatase SAC1

Gene Symbol

SAC1

Synonyms

RSD1

Chromosome

XI

EC Number

3.1.3.-

phosphatidylinositol-3-phosphatase SAC1
Refseq ID	NP_012710
Protein GI	6322637
UniProt ID	P32368
mRNA ID	NM_001179777
Length	623
MTGPIVYVQNADGIFFKLAEGKGTNDAVIHLANQDQGVRVLGAEEFPVQGEVVKIASLMGFIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFNSRIDSEEAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGPAASWKTADERFFWNHYLTEDLRNFAHQDPRIDSFIQPVIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAENPESEKIHVFSFLQTRGSVPIYWAEINNLKYKPNLVLGENSLDATKKHFDQQKELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFDFHHECRKMQWHRVKLLIDHLEKLGLSNEDFFHKVIDSNGNTVEIVNEQHSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESADVVATGSTWEDNAPLLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGAFNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSPFPDRRPVYIQLIPMIICAALTVLGATIFFPKDRFTSSKNLLYFAGASIVLALSTKFMFKNGIQFVNWPKLVDVGFLVVHQTHDKEQQFKGLKYAQSPKFSKPDPLKRD

Entrez Gene ID

Gene Name

phosphatidylinositol-3-phosphatase SAC1

Gene Symbol

SAC1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005797	IDA:SGD	C	Golgi medial cisterna
GO:0035339	IDA:UniProtKB	C	SPOTS complex
GO:0030173	IDA:SGD	C	integral component of Golgi membrane
GO:0030176	IDA:SGD	C	integral component of endoplasmic reticulum membrane
GO:0016791	IMP:SGD	F	phosphatase activity
GO:0043813	IDA:SGD	F	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
GO:0004438	IDA:SGD	F	phosphatidylinositol-3-phosphatase activity
GO:0043812	IDA:SGD	F	phosphatidylinositol-4-phosphate phosphatase activity
GO:0046856	IDA:SGD	P	phosphatidylinositol dephosphorylation
GO:0036092	IDA:GOC	P	phosphatidylinositol-3-phosphate biosynthetic process

BIOCYC Pathway ID	Description
PWY-6352	3-phosphoinositide biosynthesis
PWY-6368	3-phosphoinositide degradation
PWY3O-242	phosphatidylinositol phosphate biosynthesis
PWY-6371	superpathway of inositol phosphate compounds

REACTOME Pathway ID	Description
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618611	PI Metabolism
5618126	Phospholipid metabolism
5618613	Synthesis of PIPs at the ER membrane
5618614	Synthesis of PIPs at the Golgi membrane

Accession	Description
IPR002013	SAC domain

Gene Name

phosphatidylinositol-3-phosphatase SAC1

Protein Entry

SAC1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Caution	It is uncertain whether Met-1 or Met-59 is the initiator
Caution	It is uncertain whether Met-1 or Met-59 is the initiator. {ECO:0000305}.
Function	Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2. May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton. {ECO:0000269\|PubMed:10625610, ECO:0000269\|PubMed:11514624}.
Interaction	P38713:OSH3; NbExp=2; IntAct=EBI-16210, EBI-12630;
Miscellaneous	Present with 48000 molecules/cell in log phase SD medium
Miscellaneous	Present with 48000 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Contains 1 SAC domain. {ECO:0000255\|PROSITE- ProRule:PRU00183}.
Subcellular Location	Endoplasmic reticulum membrane ; Single-pass membrane protein .
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:11514624}; Single-pass membrane protein {ECO:0000269\|PubMed:11514624}.
Subunit	Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3
Subunit	Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3. {ECO:0000269\|PubMed:20182505}.