LIPID MAPS

LMPD ID

LMP007116

Gene ID

850940

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

lipoyl(octanoyl) transferase LIP2

Gene Symbol

LIP2

Synonyms

-

Chromosome

XII

EC Number

2.3.1.181

lipoyl(octanoyl) transferase LIP2
Refseq ID	NP_013340
Protein GI	6323268
UniProt ID	Q06005
mRNA ID	NM_001182126
Length	328
MSRCIRQSVCTNFNVCRRQCFSTYASALKEMTHPIKPSAQTLRHLQFTQRIPFQKGLEIQETLVRANLDIKDIQSKIERKLIQLDEEYKGTATINDNEKRILDKVMAMKPNPIILTFEFEPTYTGGKRIKKTMTPDQIAAYESFIPETQKDNPRPKFVQVERGGQVTFHGPGQIVIYIILDLKTFQSFPAKCLVSCIEQATIRTLKNTKMCDDTDKPLNLDAMTTKDTGVWVENGKKKVASVGIHVRRSITSHGVAINVNTDLSYMNSFEMCGLKNTLTTSIMEQRPDAVVNVQSVAISFVKEMTKLLGIKTLERMQIDDVNILKKNP

Entrez Gene ID

850940

Gene Name

lipoyl(octanoyl) transferase LIP2

Gene Symbol

LIP2

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005739	IEA:UniProtKB-KW	C	mitochondrion
GO:0016874	IMP:SGD	F	ligase activity
GO:0033819	IEA:UniProtKB-EC	F	lipoyl(octanoyl) transferase activity
GO:0016415	IEA:InterPro	F	octanoyltransferase activity
GO:0009107	IEA:InterPro	P	lipoate biosynthetic process
GO:0009249	IMP:SGD	P	protein lipoylation

KEGG Pathway Links

KEGG Pathway ID	Description
ko00785	Lipoic acid metabolism
sce00785	Lipoic acid metabolism
sce01100	Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY-7381	lipoate biosynthesis and incorporation (glycine cleavage system)
PWY-7381	lipoate biosynthesis and incorporation (glycine cleavage system, yeast)
PWY0-501	lipoate biosynthesis and incorporation I
PWY-7386	superpathway of lipoate biosynthesis and incorporation (PDH, KGDH, GCV)
PWY-7386	superpathway of lipoate biosynthesis and incorporation (PDH, KGDH, GCV, yeast)

InterPro Annotations

Accession	Description
IPR004143	Biotin/lipoate A/B protein ligase
IPR000544	Octanoyltransferase
IPR020605	Octanoyltransferase, conserved site

Entry Information

Gene Name

lipoyl(octanoyl) transferase LIP2

Protein Entry

LIPB_YEAST

UniProt ID

Q06005

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	Octanoyl-[acyl-carrier-protein] + protein = protein N(6)-(octanoyl)lysine + [acyl-carrier-protein].
Function	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
Function	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). {ECO:0000250}.
Interaction	P38800:YHR080C; NbExp=1; IntAct=EBI-10169, EBI-24597;
Miscellaneous	In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon- amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes
Miscellaneous	In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon- amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. {ECO:0000250}.
Miscellaneous	Present with 1200 molecules/cell in log phase SD medium
Miscellaneous	Present with 1200 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Pathway	Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier- protein]: step 1/2.
Similarity	Belongs to the LipB family
Similarity	Belongs to the LipB family. {ECO:0000305}.
Similarity	Contains 1 BPL/LPL catalytic domain
Similarity	Contains 1 BPL/LPL catalytic domain. {ECO:0000255\|PROSITE-ProRule:PRU01067}.
Subcellular Location	Mitochondrion .
Subcellular Location	Mitochondrion {ECO:0000305}.