Gene/Proteome Database (LMPD)

LMPD ID
LMP007102
Gene ID
853116
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
choline-phosphate cytidylyltransferase
Gene Symbol
PCT1
Synonyms
BSR2; CCT1
Alternate Names
choline-phosphate cytidylyltransferase
Chromosome
VII
EC Number
2.7.7.15

Proteins

choline-phosphate cytidylyltransferase
Refseq ID NP_011718
Protein GI 6321641
UniProt ID P13259
mRNA ID NM_001181331
Length 424
RefSeq Status PROVISIONAL
MANPTTGKSSIRAKLSNSSLSNLFKKNKNKRQREETEEQDNEDKDESKNQDENKDTQLTPRKRRRLTKEFEEKEARYTNELPKELRKYRPKGFRFNLPPTDRPIRIYADGVFDLFHLGHMKQLEQCKKAFPNVTLIVGVPSDKITHKLKGLTVLTDKQRCETLTHCRWVDEVVPNAPWCVTPEFLLEHKIDYVAHDDIPYVSADSDDIYKPIKEMGKFLTTQRTNGVSTSDIITKIIRDYDKYLMRNFARGATRQELNVSWLKKNELEFKKHINEFRSYFKKNQTNLNNASRDLYFEVREILLKKTLGKKLYSKLIGNELKKQNQRQRKQNFLDDPFTRKLIREASPATEFANEFTGENSTAKSPDDNGNLFSQEDDEDTNSNNTNTNSDSDSNTNSTPPSEDDDDNDRLTLENLTQKKKQSAN

Gene Information

Entrez Gene ID
853116
Gene Name
choline-phosphate cytidylyltransferase
Gene Symbol
PCT1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 TAS:SGD C Golgi apparatus
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005635 IDA:SGD C nuclear envelope
GO:0005634 IDA:SGD C nucleus
GO:0004105 IDA:SGD F choline-phosphate cytidylyltransferase activity
GO:0006657 IDA:SGD P CDP-choline pathway
GO:0006656 IDA:SGD P phosphatidylcholine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce00564 Glycerophospholipid metabolism
sce_M00090 Phosphatidylcholine (PC) biosynthesis, choline => PC

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3O-450 phospholipid biosynthesis (Kennedy pathway)

REACTOME Pathway Links

REACTOME Pathway ID Description
5618446 Synthesis of PC

Domain Information

InterPro Annotations

Accession Description
IPR004821 Cytidyltransferase-like domain
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

UniProt Annotations

Entry Information

Gene Name
choline-phosphate cytidylyltransferase
Protein Entry
PCY1_YEAST
UniProt ID
P13259
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity CTP + phosphocholine = diphosphate + CDP- choline.
Interaction P36156:ECM4; NbExp=1; IntAct=EBI-5254, EBI-2042717; P39005:KRE9; NbExp=1; IntAct=EBI-5254, EBI-9930;
Miscellaneous Present with 3050 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.
Similarity Belongs to the cytidylyltransferase family. {ECO:0000305}.
Subcellular Location Membrane. Note=Most of its activity is membrane-associated.

Identical and Related Proteins

Unique RefSeq proteins for LMP007102 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6321641 RefSeq NP_011718 424 choline-phosphate cytidylyltransferase

Identical Sequences to LMP007102 proteins

Reference Database Accession Length Protein Name
GI:6321641 EMBL CAY05188.1 424 unnamed protein product [Saccharomyces cerevisiae]
GI:6321641 EMBL CBF65902.1 424 unnamed protein product [Saccharomyces cerevisiae]
GI:6321641 EMBL CBU90774.1 424 unnamed protein product [Saccharomyces cerevisiae]
GI:6321641 GenBank EIW10550.1 424 Pct1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6321641 GenBank AGX57866.1 424 Sequence 16033 from patent US 8541208
GI:6321641 Third Party Genbank DAA08295.1 424 TPA: choline-phosphate cytidylyltransferase [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007102 proteins

Reference Database Accession Length Protein Name
GI:6321641 DBBJ GAA23573.1 424 K7_Pct1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6321641 EMBL CAY79960.1 424 Pct1p [Saccharomyces cerevisiae EC1118]
GI:6321641 GenBank EEU06543.1 424 Pct1p [Saccharomyces cerevisiae JAY291]
GI:6321641 GenBank EGA82707.1 424 Pct1p [Saccharomyces cerevisiae Lalvin QA23]
GI:6321641 GenBank EWG86069.1 424 Pct1p [Saccharomyces cerevisiae R008]
GI:6321641 gnl McCuskerlabDuke 424 Pct1p [Saccharomyces cerevisiae YJM993]