LIPID MAPS

LMPD ID

LMP007084

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Akr2p

Gene Symbol

AKR2

Synonyms

-

Chromosome

XV

EC Number

2.3.1.225

Akr2p
Refseq ID	NP_014677
Protein GI	6324608
UniProt ID	Q12013
mRNA ID	NM_001183453
Length	749
MTSMSIIDDENVKKTSNGAAVVTDVAQHAVSDSDNNKAQLLGDGSNTEYVVDIFIEAAKDGDLKVVKDVVESGAVDINNDRIDELSGLHWACINNRFSVAKFLLLRGANPNQAAGPGGATALHWAARYGNIYIVDLLLKHGADPTLKDEQGLNIMHFSVYSSNILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWAAYQGDFLTVELLLKFGSTVAWTDNRGFNALHCALVGGDQRVICDLILSGANFYERNNQKQDCFDLAEGMGTKSLFEQALQHHGYDRLGNQKDKLFKKSSHAQFTIFLSPFLLMVYIYLISLVLSPVLAIMLSLLVTVVMVNTLKKFVLPCLPRKNTYKVSLTRTPFFSGLFLSTFCFLIYIWTKKLYPYSVSDYTMKNVQFLVTSFLTVVLFLRLVRSDPGCLKTDDSLTSIQETIKQLIDLGKFDRENFCVETLERKPLRSKYSFFSGALVARYDHYCPWIYNDVGLKNHKLFVFFAVTVQYHMFLFMWLCLAYFKKTNYIYEQVEEYARCALLKNETLCKGSNYDPSTFFLFIWISVNFIWLGAMLIVQFFQILKGITTPELFILIKEEHKAKFINLIPFENSIYTSESKGVEDSDMIPEGPSATTITHTISIDGLEPRNRRRAILSACFSMMGINQWLVTIKEIVGITHILHGQVPQQHHSSLLRSFLVTNHWKTNLTDFWLNSDVTAPLWQRFFYSSDTSKAMLGGTEVDYYELYEYPAREGEVLRPN

Entrez Gene ID

Gene Name

Akr2p

Gene Symbol

AKR2

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005794	IDA:SGD	C	Golgi apparatus
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0016409	ISS:SGD	F	palmitoyltransferase activity
GO:0019706	IEA:UniProtKB-EC	F	protein-cysteine S-palmitoyltransferase activity
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0006897	ISS:SGD	P	endocytosis
GO:0018345	ISS:SGD	P	protein palmitoylation

Accession	Description
IPR002110	Ankyrin repeat
IPR020683	Ankyrin repeat-containing domain
IPR001594	Zinc finger, DHHC-type, palmitoyltransferase

Gene Name

Akr2p

Protein Entry

AKR2_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
Caution	It is uncertain whether Met-1 or Met-4 is the initiator
Caution	It is uncertain whether Met-1 or Met-4 is the initiator. {ECO:0000305}.
Domain	The DHHC domain is required for palmitoyltransferase activity
Domain	The DHHC domain is required for palmitoyltransferase activity. {ECO:0000250}.
Function	May be involved in constitutive endocytosis of a-factor receptor STE3
Function	May be involved in constitutive endocytosis of a-factor receptor STE3. {ECO:0000269\|PubMed:9243510}.
Miscellaneous	Present with 815 molecules/cell in log phase SD medium
Miscellaneous	Present with 815 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily
Similarity	Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. {ECO:0000305}.
Similarity	Contains 1 DHHC-type zinc finger
Similarity	Contains 1 DHHC-type zinc finger. {ECO:0000255\|PROSITE-ProRule:PRU00067}.
Similarity	Contains 6 ANK repeats. {ECO:0000255\|PROSITE- ProRule:PRU00023}.
Subcellular Location	Membrane; Multi-pass membrane protein.