Gene/Proteome Database (LMPD)

LMPD ID
LMP007080
Gene ID
856535
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Nsg1p
Gene Symbol
NSG1
Synonyms
-
Alternate Names
Nsg1p
Chromosome
VIII

Proteins

Nsg1p
Refseq ID NP_012001
Protein GI 6321925
UniProt ID P38837
mRNA ID NM_001179263
Length 291
RefSeq Status PROVISIONAL
MGKKKSKNQLNTGGVPNGVHNTKKEAALPPLGNKLGSASFTAINTLTKPALFSFYDDDITKNEGNVYDKALLSNASQLEMVPPSATARHERSLYAKIINTIAAFFILFIAGILFPMISECLFDNDQLAKGDIVSFLKHGIEIKNKIVAEPDMVPDWAVFGTEGVIFGSIVPFIDSFVRYQHQPKTRSSVYKNTLGSFIRCANTLLGLIFGIRKLEWSSSLQAAGAWSLLNIVLWLFFDGTLTVFFPGLVIGALSAFTCSQCFSQLSLALYFIDFYFFGFLMFSKLGRYLFN

Gene Information

Entrez Gene ID
856535
Gene Name
Nsg1p
Gene Symbol
NSG1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:SGD C cytosol
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005634 IDA:SGD C nucleus
GO:0051082 IMP:SGD F unfolded protein binding
GO:0016126 IMP:SGD P sterol biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR025929 Insulin-induced protein family

UniProt Annotations

Entry Information

Gene Name
Nsg1p
Protein Entry
NSG1_YEAST
UniProt ID
P38837
Species
Yeast (S288c)

Comments

Comment Type Description
Function Stabilizes the HMG-CoA reductase HMG2 by preventing its HRD1-dependent degradation. Binds directly to the sterol-sensing domain (SSD)-containing transmembrane region of HMG2, promoting its folding to protect it from degradation. {ECO:0000269|PubMed:16270032}.
Miscellaneous Present with 1900 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity To yeast YNL156c. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:16270032}; Multi-pass membrane protein {ECO:0000269|PubMed:16270032}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007080 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6321925 RefSeq NP_012001 291 Nsg1p

Identical Sequences to LMP007080 proteins

Reference Database Accession Length Protein Name
GI:6321925 DBBJ GAA23849.1 291 K7_Nsg1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6321925 GenBank EEU05758.1 291 Nsg1p [Saccharomyces cerevisiae JAY291]
GI:6321925 GenBank EGA58380.1 291 Nsg1p [Saccharomyces cerevisiae FostersB]
GI:6321925 GenBank EIW10035.1 291 Nsg1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6321925 SwissProt P38837.1 291 RecName: Full=Protein NSG1; AltName: Full=INSIG homolog 1 [Saccharomyces cerevisiae S288c]
GI:6321925 Third Party Genbank DAA06826.1 291 TPA: Nsg1p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007080 proteins

Reference Database Accession Length Protein Name
GI:6321925 EMBL CAY80144.1 291 Nsg1p [Saccharomyces cerevisiae EC1118]
GI:6321925 GenBank EDV09178.1 291 conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
GI:6321925 GenBank EGA82541.1 291 Nsg1p [Saccharomyces cerevisiae Lalvin QA23]
GI:6321925 GenBank EWG90709.1 291 Nsg1p [Saccharomyces cerevisiae P301]
GI:6321925 GenBank EWG95577.1 291 Nsg1p [Saccharomyces cerevisiae R103]
GI:6321925 gnl McCuskerlabDuke 291 Nsg1p [Saccharomyces cerevisiae YJM993]