Gene/Proteome Database (LMPD)

LMPD ID
LMP007079
Gene ID
855783
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Fpk1p
Gene Symbol
FPK1
Synonyms
-
Alternate Names
Fpk1p
Chromosome
XIV
EC Number
2.7.11.1

Proteins

Fpk1p
Refseq ID NP_014445
Protein GI 6324375
UniProt ID P53739
mRNA ID NM_001183224
Length 893
RefSeq Status PROVISIONAL
MAGHHHEHEQERDHEQEHEHDSLQRPTTGSERTRSISFSKLLTRSWKRNASSSNNMSVSSVNLYSDPENSRESDHNNSGSEGQSSRFSKLKSMFQSGNSSKNASAHNSSQSSLEGDSASSSSKLRYVKPMTSVANASPASPPLSPTIPETDVLQTPKMVHIDQHEHEREHSNCGSPIMLSSSSFSPTVARTGTGRRRSPSTPIMPSQNSNNSSSTSAIRPNNYRHHSGSQGFSSNNPFRERAGTVRSSNPYFAYQGLPTHAMSSHDLDEGFQPYANGSGIHFLSTPTSKTNSLTNTKNLSNLSLNEIKENEEVQEFNNEDFFFHDIPKDLSLKDTLNGSPSRGSSKSPTITQTFPSIIVGFDNEYEEDNNNDKHDEKEEQQTTTDNKTRNLSPTKQNGKATHPRIKIPLRRAASEPNGLQLASATSPTSSSARKTSGSSNINDKIPGQSVPPPNSFFPQEPSPKISDFPEPRRSRRLRTKSFSNKFQDIMVGPQSFEKIRLLGQGDVGKVFLVREKKTNRVYALKVLSKDEMIKRNKIKRVLTEQEILATSNHPFIVTLYHSFQSEDYLYLCMEYCMGGEFFRALQTRKTKCICEDDARFYASEVTAALEYLHLLGFIYRDLKPENILLHQSGHIMLSDFDLSIQAKDSKVPVVKGSAQSTLVDTKICSDGFRTNSFVGTEEYIAPEVIRGNGHTAAVDWWTLGILIYEMLFGFTPFKGDNTNETFTNILKNEVSFPNNNEISRTCKDLIKKLLTKNESKRLGCKMGAADVKKHPFFKKVQWSLLRNQEPPLIPVLSEDGYDFAKLSSNKKRQTSQDSHKHLDEQEKNMFEERVEYDDEVSEDDPFHDFNSMSLMEQDNNSMIYGNTNSYGKIAYTPNSNRSRSNSHRTFFKR

Gene Information

Entrez Gene ID
855783
Gene Name
Fpk1p
Gene Symbol
FPK1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:SGD C cytoplasm
GO:0005886 IDA:SGD C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004672 IDA:SGD F protein kinase activity
GO:0004674 IDA:SGD F protein serine/threonine kinase activity
GO:0006869 IEA:UniProtKB-KW P lipid transport
GO:0061092 IGI:SGD P positive regulation of phospholipid translocation
GO:0046777 IDA:SGD P protein autophosphorylation
GO:0006468 IMP:SGD P protein phosphorylation
GO:0019236 IMP:SGD P response to pheromone

REACTOME Pathway Links

REACTOME Pathway ID Description
5618242 Calmodulin induced events
5618026 Disease
5618240 Opioid Signalling
5618163 Signaling by EGFR in Cancer

Domain Information

InterPro Annotations

Accession Description
IPR000961 AGC-kinase, C-terminal
IPR011993 Pleckstrin homology-like domain
IPR000719 Protein kinase domain
IPR011009 Protein kinase-like domain
IPR008271 Serine/threonine-protein kinase, active site
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
Fpk1p
Protein Entry
FPK1_YEAST
UniProt ID
P53739
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Enzyme Regulation Down-regulated by YKP1 phosphorylation. This effect is counteracted in the presence of mannosyl- inositolphosphorylceramide (MIPC). {ECO:0000269|PubMed:19966303}.
Function Flippase activator that phosphorylates DFN1 and DFN2 and which is involved in the generation of phospholipid asymmetry in membranes by the inward translocation of phospholipids and in the retrieval pathway from early endosomes to the trans-Golgi network (TGN). Phosphorylates also the N-terminal half of YPK1. Involved in pheromone-response. {ECO:0000269|PubMed:11337509, ECO:0000269|PubMed:18199685, ECO:0000269|PubMed:19966303}.
Miscellaneous Present with 752 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Ptm The N-terminal non-catalytic domain is phosphorylated by YPK1. {ECO:0000269|PubMed:17330950, ECO:0000269|PubMed:18407956, ECO:0000269|PubMed:19779198, ECO:0000269|PubMed:19966303}.
Similarity Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. KIN82 subfamily. {ECO:0000255|PROSITE- ProRule:PRU00159}.
Similarity Contains 1 AGC-kinase C-terminal domain. {ECO:0000305}.
Similarity Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14562095}. Cell membrane {ECO:0000269|PubMed:14562095}; Peripheral membrane protein {ECO:0000269|PubMed:14562095}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007079 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324375 RefSeq NP_014445 893 Fpk1p

Identical Sequences to LMP007079 proteins

Reference Database Accession Length Protein Name
GI:6324375 EMBL CAA96328.1 893 unnamed protein product [Saccharomyces cerevisiae]
GI:6324375 EMBL CBL75217.1 893 unnamed protein product [Saccharomyces cerevisiae]
GI:6324375 GenBank EIW08138.1 893 Fpk1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6324375 SwissProt P53739.1 893 RecName: Full=Flippase kinase 1 [Saccharomyces cerevisiae S288c]
GI:6324375 Third Party Genbank DAA10588.1 893 TPA: Fpk1p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007079 proteins

Reference Database Accession Length Protein Name
GI:6324375 DBBJ GAA26140.1 893 K7_Ynr047wp [Saccharomyces cerevisiae Kyokai no. 7]
GI:6324375 EMBL CAY82242.1 893 EC1118_1N18_0936p [Saccharomyces cerevisiae EC1118]
GI:6324375 GenBank EDV12220.1 893 conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
GI:6324375 GenBank EHN04957.1 893 YNR047W-like protein [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6324375 GenBank EWH16285.1 893 hypothetical protein P283_N21031 [Saccharomyces cerevisiae P283]
GI:6324375 gnl McCuskerlabDuke 893 Fpk1p [Saccharomyces cerevisiae YJM993]