LIPID MAPS

LMPD ID

LMP007063

Gene ID

852507

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

bifunctional urea carboxylase/allophanate hydrolase

Gene Symbol

DUR1,2

Synonyms

DUR80

Chromosome

II

EC Number

6.3.4.6

bifunctional urea carboxylase/allophanate hydrolase
Refseq ID	NP_009767
Protein GI	6319685
UniProt ID	P32528
mRNA ID	NM_001178556
Length	1835
MTVSSDTTAEISLGWSIQDWIDFHKSSSSQASLRLLESLLDSQNVAPVDNAWISLISKENLLHQFQILKSRENKETLPLYGVPIAVKDNIDVRGLPTTAACPSFAYEPSKDSKVVELLRNAGAIIVGKTNLDQFATGLVGTRSPYGKTPCAFSKEHVSGGSSAGSASVVARGIVPIALGTDTAGSGRVPAALNNLIGLKPTKGVFSCQGVVPACKSLDCVSIFALNLSDAERCFRIMCQPDPDNDEYSRPYVSNPLKKFSSNVTIAIPKNIPWYGETKNPVLFSNAVENLSRTGANVIEIDFEPLLELARCLYEGTWVAERYQAIQSFLDSKPPKESLDPTVISIIEGAKKYSAVDCFSFEYKRQGILQKVRRLLESVDVLCVPTCPLNPTMQQVADEPVLVNSRQGTWTNFVNLADLAALAVPAGFRDDGLPNGITLIGKKFTDYALLELANRYFQNIFPNGSRTYGTFTSSSVKPANDQLVGPDYDPSTSIKLAVVGAHLKGLPLHWQLEKVNATYLCTTKTSKAYQLFALPKNGPVLKPGLRRVQDSNGSQIELEVYSVPKELFGAFISMVPEPLGIGSVELESGEWIKSFICEESGYKAKGTVDITKYGGFRAYFEMLKKKESQKKKLFDTVLIANRGEIAVRIIKTLKKLGIRSVAVYSDPDKYSQHVTDADVSVPLHGTTAAQTYLDMNKIIDAAKQTNAQAIIPGYGFLSENADFSDACTSAGITFVGPSGDIIRGLGLKHSARQIAQKAGVPLVPGSLLITSVEEAKKVAAELEYPVMVKSTAGGGGIGLQKVDSEEDIEHIFETVKHQGETFFGDAGVFLERFIENARHVEVQLMGDGFGKAIALGERDCSLQRRNQKVIEETPAPNLPEKTRLALRKAAESLGSLLNYKCAGTVEFIYDEKKDEFYFLEVNTRLQVEHPITEMVTGLDLVEWMIRIAANDAPDFDSTKVEVNGVSMEARLYAENPLKNFRPSPGLLVDVKFPDWARVDTWVKKGTNISPEYDPTLAKIIVHGKDRDDAISKLNQALEETKVYGCITNIDYLKSIITSDFFAKAKVSTNILNSYQYEPTAIEITLPGAHTSIQDYPGRVGYWRIGVPPSGPMDAYSFRLANRIVGNDYRTPAIEVTLTGPSIVFHCETVIAITGGTALCTLDGQEIPQHKPVEVKRGSTLSIGKLTSGCRAYLGIRGGIDVPKYLGSYSTFTLGNVGGYNGRVLKLGDVLFLPSNEENKSVECLPQNIPQSLIPQISETKEWRIGVTCGPHGSPDFFKPESIEEFFSEKWKVHYNSNRFGVRLIGPKPKWARSNGGEGGMHPSNTHDYVYSLGAINFTGDEPVIITCDGPSLGGFVCQAVVPEAELWKVGQVKPGDSIQFVPLSYESSRSLKESQDVAIKSLDGTKLRRLDSVSILPSFETPILAQMEKVNELSPKVVYRQAGDRYVLVEYGDNEMNFNISYRIECLISLVKKNKTIGIVEMSQGVRSVLIEFDGYKVTQKELLKVLVAYETEIQFDENWKITSNIIRLPMAFEDSKTLACVQRYQETIRSSAPWLPNNVDFIANVNGISRNEVYDMLYSARFMVLGLGDVFLGSPCAVPLDPRHRFLGSKYNPSRTYTERGAVGIGGMYMCIYAANSPGGYQLVGRTIPIWDKLCLAASSEVPWLMNPFDQVEFYPVSEEDLDKMTEDCDNGVYKVNIEKSVFDHQEYLRWINANKDSITAFQEGQLGERAEEFAKLIQNANSELKESVTVKPDEEEDFPEGAEIVYSEYSGRFWKSIASVGDVIEAGQGLLIIEAMKAEMIISAPKSGKIIKICHGNGDMVDSGDIVAVIETLA

Entrez Gene ID

852507

Gene Name

bifunctional urea carboxylase/allophanate hydrolase

Gene Symbol

DUR1,2

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0004039	IMP:SGD	F	allophanate hydrolase activity
GO:0004075	IEA:InterPro	F	biotin carboxylase activity
GO:0016884	IEA:InterPro	F	carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0046872	IEA:InterPro	F	metal ion binding
GO:0004847	IMP:SGD	F	urea carboxylase activity
GO:0000256	TAS:SGD	P	allantoin catabolic process
GO:0006525	IEA:UniProtKB-KW	P	arginine metabolic process
GO:0043419	IMP:SGD	P	urea catabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
ko00330	Arginine and proline metabolism
sce00330	Arginine and proline metabolism
sce01100	Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
ALLANTOINDEG-PWY	superpathway of allantoin degradation in yeast
ALLANTOINDEG-PWY	superpathway of allantoin degradation in yeast
PWY-5703	urea degradation
PWY-5703	urea degradation I

InterPro Annotations

Accession	Description
IPR011761	ATP-grasp fold
IPR013815	ATP-grasp fold, subdomain 1
IPR013816	ATP-grasp fold, subdomain 2
IPR003833	Allophan_hydro_1
IPR003778	Allophan_hydro_2
IPR014085	Allophanate_hydrolase
IPR000120	Amidase
IPR023631	Amidase signature domain
IPR024946	Arg_repress_C-like
IPR005482	Biotin carboxylase, C-terminal
IPR011764	Biotin carboxylation domain
IPR001882	Biotin-binding site
IPR000089	Biotin/lipoyl attachment
IPR005481	Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005479	Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR029000	Cyclophilin-like domain
IPR016185	Pre-ATP-grasp domain
IPR011054	Rudiment single hybrid motif
IPR011053	Single hybrid motif
IPR014084	Urea_COase

Entry Information

Gene Name

bifunctional urea carboxylase/allophanate hydrolase

Protein Entry

DUR1_YEAST

UniProt ID

P32528

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	ATP + urea + HCO(3)(-) = ADP + phosphate + urea-1-carboxylate.
Catalytic Activity	Urea-1-carboxylate + H(2)O = 2 CO(2) + 2 NH(3).
Cofactor	Name=biotin; Xref=ChEBI:CHEBI:57586; Note=Biotin.;
Function	Hydrolysis of urea to ammonia and CO(2).
Induction	By allophanate or its non-metabolized analog oxalurate. Repressed in the presence of readily used nitrogen sources.
Miscellaneous	Present with 952 molecules/cell in log phase SD medium
Miscellaneous	Present with 952 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Pathway	Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (allophanate route): step 1/2.
Pathway	Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (allophanate route): step 2/2.
Similarity	Contains 1 ATP-grasp domain. {ECO:0000255\|PROSITE- ProRule:PRU00409}.
Similarity	Contains 1 biotin carboxylation domain
Similarity	Contains 1 biotin carboxylation domain. {ECO:0000305}.
Similarity	Contains 1 biotinyl-binding domain
Similarity	Contains 1 biotinyl-binding domain. {ECO:0000255\|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subunit	Monomer.