Gene/Proteome Database (LMPD)

LMPD ID
LMP007033
Gene ID
850648
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Yeh1p
Gene Symbol
YEH1
Synonyms
-
Alternate Names
Yeh1p
Chromosome
XII
EC Number
3.1.1.13

Proteins

Yeh1p
Refseq ID NP_013089
Protein GI 6323017
UniProt ID Q07804
mRNA ID NM_001181832
Length 573
RefSeq Status PROVISIONAL
MGVSAVLKRARNLLATFIVCCFMAVVLVLALAHHFINEHRDTRSSSTQIEVDDESKRNVHHDHVLTRTNAYATPYLDLEHDKKNGIVYDHTRTVVRKKNHEVGSSSLHKNLFHKFLTKLIFRFIEKEKVTEGVTQGKFNNSSNEIANHEPVFEKIPVQCDNPLQNLILSEDLTLVADLNYYFNQYNIQIEEFRLETEDGFVIDLWHLIPKYRTTDSDKKKRPPILMLHGLLQSSGSFASNGRKSLAYFLYQSGYDIWLGNNRCGFRPEWNEAKVPTLASRWDWDLREMVKYDLTLLIDTVLAKTQFEKLTLISHSQGTTQGFMGLVNEDKFFPPGSGSKESFFTSKIANYIALAPAVYPGPLLNEKLFVKLMTKEIENPWFFGETSFFEIMMIVRNLCVGESLFSFVCYTIFNYLFDWNDTLWDTALRDRHFLFSPVHVSVKLMQWWLSPDPNKVSFKFGSHKMFPDNVKWFSDASKAPNIYLFVPKQDRLVDGERLINHFVNVESNVNYKIWYIDEYAHIDVLWAHDVIERIGKPILQNLNNYYSKKPSSAFESDCSDTEVETELEMVAEKA

Gene Information

Entrez Gene ID
850648
Gene Name
Yeh1p
Gene Symbol
YEH1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IDA:SGD C integral component of membrane
GO:0005811 IDA:SGD C lipid particle
GO:0004771 IDA:SGD F sterol esterase activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0016125 IMP:SGD P sterol metabolic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7424 sterol:steryl ester interconversion
PWY-7424 sterol:steryl ester interconversion (yeast)

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR006693 Partial AB-hydrolase lipase domain

UniProt Annotations

Entry Information

Gene Name
Yeh1p
Protein Entry
YEH1_YEAST
UniProt ID
Q07804
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity A steryl ester + H(2)O = a sterol + a fatty acid.
Function Mediates the hydrolysis of steryl esters, thereby playing a central role in lipid metabolism. Under heme-deficient conditions, it constitutes the major steryl ester hydrolase, suggesting that it plays a central role in mobilization of steryl esters under anaerobic conditions. {ECO:0000269|PubMed:15713625, ECO:0000269|PubMed:16835446}.
Induction Under heme-deficiency conditions. Heme-deficient induction requires ROX3. {ECO:0000269|PubMed:16835446}.
Miscellaneous Present with 7770 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Ptm Not N-glycosylated.
Similarity Belongs to the AB hydrolase superfamily. {ECO:0000305}.
Subcellular Location Lipid droplet. Membrane; Peripheral membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP007033 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323017 RefSeq NP_013089 573 Yeh1p

Identical Sequences to LMP007033 proteins

Reference Database Accession Length Protein Name
GI:6323017 EMBL CAA97456.1 573 unnamed protein product [Saccharomyces cerevisiae]
GI:6323017 EMBL CAA62780.1 573 L1329 protein [Saccharomyces cerevisiae]
GI:6323017 GenBank EIW09046.1 573 Yeh1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6323017 SwissProt Q07804.1 573 RecName: Full=Sterol esterase 1; AltName: Full=Steryl ester hydrolase 1 [Saccharomyces cerevisiae S288c]
GI:6323017 Third Party Genbank DAA09306.1 573 TPA: Yeh1p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007033 proteins

Reference Database Accession Length Protein Name
GI:6323017 DBBJ GAA24876.1 573 K7_Yeh1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6323017 GenBank EDN59535.1 573 steryl ester hydrolase [Saccharomyces cerevisiae YJM789]
GI:6323017 GenBank EGA77813.1 573 Yeh1p [Saccharomyces cerevisiae Vin13]
GI:6323017 GenBank EGA85736.1 573 Yeh1p [Saccharomyces cerevisiae VL3]
GI:6323017 GenBank EHN05803.1 573 Yeh1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6323017 gnl McCuskerlabDuke 573 Yeh1p [Saccharomyces cerevisiae YJM993]