LIPID MAPS

LMPD ID

LMP007025

Gene ID

852563

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Rgd1p

Gene Symbol

RGD1

Synonyms

-

Chromosome

II

Rgd1p
Refseq ID	NP_009819
Protein GI	6319737
UniProt ID	P38339
mRNA ID	NM_001178608
Length	666
MEETAKKPASATVSAKSSHDGGTDDLAHLFSTPEIKKVLNSDVAINALLSRLKQSLLTCEEFMKFIRKKYAFEEEHVQELSKQYKHFFNIQGSTNSSLKKMIHEVLGFDGKMAQVKQSYITALQKMYSEISSLLLTMTKLRKSVKENSKRLEKDVSDAIHSAEKAQSRYNSLCQDWDKLRMTDPTKTKLTLRGSKTTKEQEEELLRKIDNADLEYKQKVDHSNSLRNTFITKERPRIVQELKDLILEIDTAMTIQLQKYTIWTENLVLNTGVTISPLDSTKSMKSFAGSVSNERDLYSFLNKYNQTGKHSLLINKNLIPVSYKKHPSMNHGQKNKSPPKFAVDPSRNSIPKRMISTHNESPFLSSSSNTAAVPNANLNSATPSLNTNKQLPPTMASSISSTSNAAGAMSPSSSIVTSDTTSSITKTLDPGNNSPQIPEELINSLDSDRPISHIQTNNNMPPGVQKNFKTFGVPLESLIEFEQDMVPAIVRQCIYVIDKFGLDQEGIYRKSANVLDVSKLKEEIDKDPANISMILPSKPHSDSDIYLVGSLLKTFFASLPDSVLPKALSSEIKVCLQIEDPTTRKNFMHGLIYNLPDAQYWTLRALVFHLKRVLAHEAQNRMNLRALCIIWGPTIAPANPDDANDVNFQIMAMEVLLEVSDQAFEPE

Entrez Gene ID

852563

Gene Name

Rgd1p

Gene Symbol

RGD1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0030479	IDA:SGD	C	actin cortical patch
GO:0005933	IDA:SGD	C	cellular bud
GO:0005100	IDA:SGD	F	Rho GTPase activator activity
GO:0080025	IDA:SGD	F	phosphatidylinositol-3,5-bisphosphate binding
GO:0032266	IDA:SGD	F	phosphatidylinositol-3-phosphate binding
GO:0005546	IDA:SGD	F	phosphatidylinositol-4,5-bisphosphate binding
GO:0070273	IDA:SGD	F	phosphatidylinositol-4-phosphate binding
GO:0010314	IDA:SGD	F	phosphatidylinositol-5-phosphate binding
GO:0007231	IGI:SGD	P	osmosensory signaling pathway
GO:0032321	IDA:GOC	P	positive regulation of Rho GTPase activity
GO:0010447	IMP:SGD	P	response to acidic pH

REACTOME Pathway Links

REACTOME Pathway ID	Description
5618264	Apoptosis
5618441	Regulation of Apoptosis
5618442	Regulation of PAK-2p34 activity by PS-GAP/RHG10
5618363	Rho GTPase cycle
5618100	Signal Transduction
5618364	Signaling by Rho GTPases

InterPro Annotations

Accession	Description
IPR001060	FCH domain
IPR008936	Rho GTPase activation protein
IPR000198	Rho GTPase-activating protein domain

Entry Information

Gene Name

Rgd1p

Protein Entry

RGD1_YEAST

UniProt ID

P38339

Species

Yeast (S288c)

Comments

Comment Type	Description
Function	GTPase activating protein of RHO3 and RHO4. Acts in concert with MID2 in cell integrity, which is functionally linked to the PKC pathway. Involved in various stress responses. Required at low pH for activation of the PKC pathway. Important during mating response. {ECO:0000269\|PubMed:10526184, ECO:0000269\|PubMed:10590461, ECO:0000269\|PubMed:11779787, ECO:0000269\|PubMed:15922872, ECO:0000269\|PubMed:16087742}.
Induction	Induced by stress including low pH, heat shock and oxidative shock. Basal and acid-stressed expression level is regulated by transcription factors MSN2 and MSN4 as well as the HOG pathway.
Interaction	P46949:FYV8; NbExp=3; IntAct=EBI-15065, EBI-23450;
Miscellaneous	Lack of RGD1 diminishes the PKC pathway activity.
Miscellaneous	Present with 1500 molecules/cell in log phase SD medium
Miscellaneous	Present with 1500 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Ptm	Phosphorylated in vivo. In vitro, phosphorylated by IPL1
Ptm	Phosphorylated in vivo. In vitro, phosphorylated by IPL1. {ECO:0000269\|PubMed:19779198, ECO:0000269\|PubMed:23454383}.
Similarity	Contains 1 FCH domain. {ECO:0000255\|PROSITE- ProRule:PRU00083}.
Similarity	Contains 1 Rho-GAP domain. {ECO:0000255\|PROSITE- ProRule:PRU00172}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:23454383}. Note=Bud and bud neck. During isotropic bud growth in the G1 and S phases, detected at the bud tip. During cytokinesis, undetectable at the bud tip and localized at the bud neck only.