LIPID MAPS

LMPD ID

LMP007006

Gene ID

851061

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Kap95p

Gene Symbol

KAP95

Synonyms

RSL1

Chromosome

XII

Kap95p
Refseq ID	NP_013451
Protein GI	6323379
UniProt ID	Q06142
mRNA ID	NM_001182236
Length	861
MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLFSQATKDTARWAREQQKRQLSL

Entrez Gene ID

851061

Gene Name

Kap95p

Gene Symbol

KAP95

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:SGD	C	cytoplasm
GO:0005634	IEA:UniProtKB-KW	C	nucleus
GO:0005087	IDA:SGD	F	Ran guanyl-nucleotide exchange factor activity
GO:0008565	IDA:SGD	F	protein transporter activity
GO:0051292	IMP:SGD	P	nuclear pore complex assembly
GO:0006656	IMP:SGD	P	phosphatidylcholine biosynthetic process
GO:0032853	IDA:GOC	P	positive regulation of Ran GTPase activity
GO:0006606	IMP:SGD	P	protein import into nucleus
GO:0006612	IMP:SGD	P	protein targeting to membrane
GO:0060188	IMP:SGD	P	regulation of protein desumoylation

KEGG Pathway Links

KEGG Pathway ID	Description
ko03013	RNA transport
sce03013	RNA transport

InterPro Annotations

Accession	Description
IPR011989	Armadillo-like helical
IPR016024	Armadillo-type fold
IPR000357	HEAT
IPR021133	HEAT, type 2
IPR001494	Importin-beta_N
IPR027140	KPNB1

Entry Information

Gene Name

Kap95p

Protein Entry

IMB1_YEAST

UniProt ID

Q06142

Species

Yeast (S288c)

Comments

Comment Type	Description
Function	Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of histones H2A and H2B
Function	Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of histones H2A and H2B. {ECO:0000269\|PubMed:11309407}.
Interaction	P14907:NSP1; NbExp=3; IntAct=EBI-9145, EBI-12265; P20676:NUP1; NbExp=6; IntAct=EBI-9145, EBI-12392; Q02629:NUP100; NbExp=4; IntAct=EBI-9145, EBI-11698; Q02630:NUP116; NbExp=4; IntAct=EBI-9145, EBI-11703; P40477:NUP159; NbExp=3; IntAct=EBI-9145, EBI-11747; P32499:NUP2; NbExp=5; IntAct=EBI-9145, EBI-12401; P49686:NUP42; NbExp=2; IntAct=EBI-9145, EBI-12310; Q02199:NUP49; NbExp=2; IntAct=EBI-9145, EBI-12315; P48837:NUP57; NbExp=2; IntAct=EBI-9145, EBI-12324; P39705:NUP60; NbExp=4; IntAct=EBI-9145, EBI-20731; Q02821:SRP1; NbExp=5; IntAct=EBI-9145, EBI-1797;
Miscellaneous	Binds to nucleoporin FxFG but not GLFG repeat regions. Ran-GTP can disrupt the karyopherin heterodimer by binding to the beta subunit and releases both subunits from the docking site.
Miscellaneous	Present with 51700 molecules/cell in log phase SD medium
Miscellaneous	Present with 51700 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Miscellaneous	The stoichiometric complex between the beta subunit and Ran-GTP renders the latter inaccessible to Ran-specific GTPase activating protein (Ran-GAP) thereby inhibiting GTP hydrolysis stimulated by Ran-GAP.
Similarity	Belongs to the importin beta family
Similarity	Belongs to the importin beta family. {ECO:0000305}.
Similarity	Contains 1 importin N-terminal domain
Similarity	Contains 1 importin N-terminal domain. {ECO:0000255\|PROSITE-ProRule:PRU00115}.
Similarity	Contains 8 HEAT repeats. {ECO:0000255\|PROSITE- ProRule:PRU00103}.
Subcellular Location	Cytoplasm . Nucleus envelope .
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus envelope {ECO:0000250}.
Subunit	Forms a complex with importin alpha subunit.