LIPID MAPS

LMPD ID

LMP006997

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

type 2C protein phosphatase PTC4

Gene Symbol

PTC4

Synonyms

GCT1

Chromosome

II

EC Number

3.1.3.16;

type 2C protein phosphatase PTC4
Refseq ID	NP_009683
Protein GI	6319601
UniProt ID	P38089
mRNA ID	NM_001178473
Length	393
MGQLLSHPLTEKTIEYNEYKNNQASTGIVPRFYNCVGSMQGYRLTQEDAHLIRNENSVVYVRFFNPFIDKYETLSLNVFAVFDGHGGDDCSKFLSGGRHHRDGNGSSNGNGEPNAGLIKWIAYSFENHHYTSTTNNDSSKFKRSFNTLEGLVSQIFKDAFILQDEELYRHFANSSCGSTAVVACIINEESLYVANCGDSRCILSSKSNGIKTMSFDHKPQHIGELIRINDNGGTVSLGRVGGVLALSRAFSDFQFKRGVTYPHRRTKLTNITQNLTYGTPPQEAQVTVEPDVLMHKIDYSKDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTKLDTIITKLLDHGIAQANSNTGVGFDNMTAIIVVLNRKGETLQDWFNKMKTRLERERGLV

Entrez Gene ID

Gene Name

type 2C protein phosphatase PTC4

Gene Symbol

PTC4

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0004722	IDA:SGD	F	protein serine/threonine phosphatase activity
GO:0006470	IDA:SGD	P	protein dephosphorylation

REACTOME Pathway ID	Description
5618467	Energy dependent regulation of mTOR by LKB1-AMPK
5618145	IGF1R signaling cascade
5618141	IRS-mediated signalling
5618142	IRS-related events
5618144	IRS-related events triggered by IGF1R
5618143	Insulin receptor signalling cascade
5618140	PI3K Cascade
5618303	PKB-mediated events
5618466	Regulation of AMPK activity via LKB1
5618100	Signal Transduction
5618099	Signaling by Insulin receptor
5618146	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
5618302	mTOR signalling

Accession	Description
IPR015655	Protein phosphatase 2C
IPR001932	Protein phosphatase 2C (PP2C)-like domain
IPR000222	Protein phosphatase 2C, manganese/magnesium aspartate binding site

Gene Name

type 2C protein phosphatase PTC4

Protein Entry

PP2C4_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 magnesium or manganese ions per subunit. ;
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250};
Interaction	Q12447:PAA1; NbExp=5; IntAct=EBI-12814, EBI-33397;
Miscellaneous	Present with 149 molecules/cell in log phase SD medium
Miscellaneous	Present with 149 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the PP2C family
Similarity	Belongs to the PP2C family. {ECO:0000305}.