LIPID MAPS

LMPD ID

LMP006996

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Ppz1p

Gene Symbol

PPZ1

Synonyms

-

Chromosome

XIII

EC Number

3.1.3.16;

Ppz1p
Refseq ID	NP_013696
Protein GI	6323625
UniProt ID	P26570
mRNA ID	NM_001182374
Length	692
MGNSSSKSSKKDSHSNSSSRNPRPQVSRTETSHSVKSAKSNKSSRSRRSLPSSSTTNTNSNVPDPSTPSKPNLEVNHQRHSSHTNRYHFPSSSHSHSNSQNELLTTPSSSSTKRPSTSRRSSYNTKAAADLPPSMIQMEPKSPILKTNNSSTHVSKHKSSYSSTYYENALTDDDNDDKDNDISHTKRFSRSSNSRPSSIRSGSVSRRKSDVTHEEPNNGSYSSNNQENYLVQALTRSNSHASSLHSRKSSFGSDGNTAYSTPLNSPGLSKLTDHSGEYFTSNSTSSLNHHSSRDIYPSKHISNDDDIENSSQLSNIHASMENVNDKNNNITDSKKDPNEEFNDIMQSSGNKNAPKKFKKPIDIDETIQKLLDAGYAAKRTKNVCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDPLDSAALKQVMKKGRQERKLANQQQQMMETSITNDNESQQ

Entrez Gene ID

Gene Name

Ppz1p

Gene Symbol

PPZ1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0019897	IDA:SGD	C	extrinsic component of plasma membrane
GO:0005634	IDA:SGD	C	nucleus
GO:0048037	IEA:InterPro	F	cofactor binding
GO:0004724	IEA:InterPro	F	magnesium-dependent protein serine/threonine phosphatase activity
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0004722	IDA:SGD	F	protein serine/threonine phosphatase activity
GO:0034613	IMP:SGD	P	cellular protein localization
GO:0006883	IMP:SGD	P	cellular sodium ion homeostasis
GO:0006470	IMP:SGD	P	protein dephosphorylation

Accession	Description
IPR004843	Calcineurin-like phosphoesterase domain, apaH type
IPR029052	Metallo-dependent phosphatase-like
IPR011159	PPPtase_PPZ
IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

Gene Name

Ppz1p

Protein Entry

PPZ1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Caution	Was originally thought to originate from a rabbit cDNA library and was known as protein phosphatase Z (PP-Z)
Caution	Was originally thought to originate from a rabbit cDNA library and was known as protein phosphatase Z (PP-Z). {ECO:0000305\|PubMed:2166691}.
Cofactor	Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 manganese ions per subunit. ;
Cofactor	Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 manganese ions per subunit. {ECO:0000250};
Enzyme Regulation	Inhibited by the regulatory subunits VHS3 and SIS2.
Function	Essential for the maintenance of cell size and integrity in response to osmotic stress.
Interaction	P36076:CAB3; NbExp=6; IntAct=EBI-13807, EBI-26778; P36024:SIS2; NbExp=5; IntAct=EBI-13807, EBI-17250; Q08438:VHS3; NbExp=4; IntAct=EBI-13807, EBI-30482;
Miscellaneous	Present with 217 molecules/cell in log phase SD medium
Miscellaneous	Present with 217 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the PPP phosphatase family. PP-Z subfamily
Similarity	Belongs to the PPP phosphatase family. PP-Z subfamily. {ECO:0000305}.
Subunit	Interacts with SIS2 and VHS3, which regulate its activity. {ECO:0000269\|PubMed:15192104, ECO:0000269\|PubMed:9636153}.