Gene/Proteome Database (LMPD)
Proteins
| methylsterol monooxygenase | |
|---|---|
| Refseq ID | NP_011574 |
| Protein GI | 398365435 |
| UniProt ID | P53045 |
| mRNA ID | NM_001181189 |
| Length | 309 |
| RefSeq Status | PROVISIONAL |
| MSAVFNNATLSGLVQASTYSQTLQNVAHYQPQLNFMEKYWAAWYSYMNNDVLATGLMFFLLHEFMYFFRCLPWFIIDQIPYFRRWKLQPTKIPSAKEQLYCLKSVLLSHFLVEAIPIWTFHPMCEKLGITVEVPFPSLKTMALEIGLFFVLEDTWHYWAHRLFHYGVFYKYIHKQHHRYAAPFGLSAEYAHPAETLSLGFGTVGMPILYVMYTGKLHLFTLCVWITLRLFQAVDSHSGYDFPWSLNKIMPFWAGAEHHDLHHHYFIGNYASSFRWWDYCLDTESGPEAKASREERMKKRAENNAQKKTN | |
Gene Information
Entrez Gene ID
Gene Name
methylsterol monooxygenase
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | IDA:SGD | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IDA:SGD | C | plasma membrane |
| GO:0000254 | IDA:SGD | F | C-4 methylsterol oxidase activity |
| GO:0005506 | IEA:InterPro | F | iron ion binding |
| GO:0006696 | IDA:SGD | P | ergosterol biosynthetic process |
| GO:0006633 | IEA:InterPro | P | fatty acid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| sce00100 | Steroid biosynthesis |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| ERGOSTEROL-SYN-PWY | superpathway of ergosterol biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5618346 | Cholesterol biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR006694 | Fatty_acid_hydroxylase |
UniProt Annotations
Entry Information
Gene Name
methylsterol monooxygenase
Protein Entry
MSMO_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest- 7-ene-4-alpha-carbaldehyde + NAD(P)H + O(2) = 3-beta-hydroxy-4- beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD(P)(+) + H(2)O. |
| Catalytic Activity | 4,4-dimethyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha- cholest-7-en-3-beta-ol + NAD(P)(+) + H(2)O. |
| Catalytic Activity | 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha- cholest-7-en-3-beta-ol + NAD(P)H + O(2) = 3-beta-hydroxy-4-beta- methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)(+) + 2 H(2)O. |
| Cofactor | Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000269|PubMed:8663358}; |
| Domain | The histidine box domains may contain the active site and/or be involved in metal ion binding. |
| Function | Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol. {ECO:0000269|PubMed:8663358}. |
| Interaction | P10614:ERG11; NbExp=3; IntAct=EBI-6506, EBI-5127; Q12452:ERG27; NbExp=4; IntAct=EBI-6506, EBI-38132; P40030:ERG28; NbExp=3; IntAct=EBI-6506, EBI-22518; P32353:ERG3; NbExp=3; IntAct=EBI-6506, EBI-6554; |
| Miscellaneous | Present with 77100 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Pathway | Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6. |
| Similarity | Belongs to the sterol desaturase family. {ECO:0000305}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305|PubMed:12119386, ECO:0000305|PubMed:15716577, ECO:0000305|PubMed:8663358}; Single-pass membrane protein {ECO:0000305|PubMed:12119386, ECO:0000305|PubMed:15716577, ECO:0000305|PubMed:8663358}. |
| Subunit | Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation- related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. Interacts with ERG27 and ERG28. {ECO:0000269|PubMed:12119386, ECO:0000269|PubMed:15995173}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006993 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 398365435 | RefSeq | NP_011574 | 309 | methylsterol monooxygenase |
Identical Sequences to LMP006993 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:398365435 | GenBank | EHN07169.1 | 309 | Erg25p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7] |
| GI:398365435 | GenBank | AGA48856.1 | 309 | Sequence 78 from patent US 8324455 |
| GI:398365435 | GenBank | EWG85951.1 | 309 | Erg25p [Saccharomyces cerevisiae R008] |
| GI:398365435 | GenBank | EWG91037.1 | 309 | Erg25p [Saccharomyces cerevisiae P301] |
| GI:398365435 | GenBank | EWG95854.1 | 309 | Erg25p [Saccharomyces cerevisiae R103] |
| GI:398365435 | gnl | McCuskerlabDuke | 309 | Erg25p [Saccharomyces cerevisiae YJM993] |
Related Sequences to LMP006993 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:398365435 | EMBL | CAY79820.1 | 309 | Erg25p [Saccharomyces cerevisiae EC1118] |
| GI:398365435 | GenBank | AAS56153.1 | 309 | YGR060W [Saccharomyces cerevisiae] |
| GI:398365435 | GenBank | EGA58592.1 | 309 | Erg25p [Saccharomyces cerevisiae FostersB] |
| GI:398365435 | GenBank | EGA78932.1 | 309 | Erg25p [Saccharomyces cerevisiae Vin13] |
| GI:398365435 | GenBank | EGA82832.1 | 309 | Erg25p [Saccharomyces cerevisiae Lalvin QA23] |
| GI:398365435 | GenBank | AGD27492.1 | 309 | Sequence 24948 from patent US 8343764 |