LIPID MAPS

LMPD ID

LMP006969

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

isocitrate dehydrogenase (NADP(+)) IDP3

Gene Symbol

IDP3

Synonyms

-

Chromosome

XIV

EC Number

1.1.1.42

isocitrate dehydrogenase (NADP(+)) IDP3
Refseq ID	NP_014389
Protein GI	398365479
UniProt ID	P53982
mRNA ID	NM_001182848
Length	420
MSKIKVVHPIVEMDGDEQTRVIWKLIKEKLILPYLDVDLKYYDLSIQERDRTNDQVTKDSSYATLKYGVAVKCATITPDEARMKEFNLKEMWKSPNGTIRNILGGTVFREPIIIPKIPRLVPHWEKPIIIGRHAFGDQYRATDIKIKKAGKLRLQFSSDDGKENIDLKVYEFPKSGGIAMAMFNTNDSIKGFAKASFELALKRKLPLFFTTKNTILKNYDNQFKQIFDNLFDKEYKEKFQALKITYEHRLIDDMVAQMLKSKGGFIIAMKNYDGDVQSDIVAQGFGSLGLMTSILITPDGKTFESEAAHGTVTRHFRKHQRGEETSTNSIASIFAWTRAIIQRGKLDNTDDVIKFGNLLEKATLDTVQVGGKMTKDLALMLGKTNRSSYVTTEEFIDEVAKRLQNMMLSSNEDKKGMCKL

Entrez Gene ID

Gene Name

isocitrate dehydrogenase (NADP(+)) IDP3

Gene Symbol

IDP3

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005737	IDA:SGD	C	cytoplasm
GO:0005777	IDA:SGD	C	peroxisome
GO:0051287	IEA:InterPro	F	NAD binding
GO:0004450	IDA:SGD	F	isocitrate dehydrogenase (NADP+) activity
GO:0000287	IEA:InterPro	F	magnesium ion binding
GO:0006740	TAS:SGD	P	NADPH regeneration
GO:0006635	IMP:SGD	P	fatty acid beta-oxidation
GO:0006097	IEA:UniProtKB-KW	P	glyoxylate cycle
GO:0006102	IEA:InterPro	P	isocitrate metabolic process
GO:0006099	IEA:UniProtKB-KW	P	tricarboxylic acid cycle

KEGG Pathway ID	Description
ko01210	2-Oxocarboxylic acid metabolism
sce01210	2-Oxocarboxylic acid metabolism
ko01230	Biosynthesis of amino acids
sce01230	Biosynthesis of amino acids
sce01110	Biosynthesis of secondary metabolites
ko01200	Carbon metabolism
sce01200	Carbon metabolism
ko00020	Citrate cycle (TCA cycle)
sce00020	Citrate cycle (TCA cycle)
M00009	Citrate cycle (TCA cycle, Krebs cycle)
sce_M00009	Citrate cycle (TCA cycle, Krebs cycle)
M00010	Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
sce_M00010	Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
ko00480	Glutathione metabolism
sce00480	Glutathione metabolism
sce01100	Metabolic pathways
ko04146	Peroxisome
sce04146	Peroxisome

REACTOME Pathway ID	Description
5618558	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
5618051	Citric acid cycle (TCA cycle)
5618026	Disease
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618472	NADPH regeneration
5618473	Peroxisomal lipid metabolism
5618052	Pyruvate metabolism and Citric Acid (TCA) cycle
5618053	The citric acid (TCA) cycle and respiratory electron transport

Accession	Description
IPR019818	Isocitrate/isopropylmalate dehydrogenase, conserved site
IPR004790	Isocitrate_DH_NADP
IPR024084	Isopropylmalate dehydrogenase-like domain

Gene Name

isocitrate dehydrogenase (NADP(+)) IDP3

Protein Entry

IDHH_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit. ;
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit. {ECO:0000250};
Function	May function in the production of NADPH for fatty acid and sterol synthesis.
Similarity	Belongs to the isocitrate and isopropylmalate dehydrogenases family
Similarity	Belongs to the isocitrate and isopropylmalate dehydrogenases family. {ECO:0000305}.