Gene/Proteome Database (LMPD)

LMPD ID
LMP006947
Gene ID
856079
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
acetyl-CoA C-acetyltransferase
Gene Symbol
ERG10
Synonyms
LPB3; TSM0115
Chromosome
XVI
EC Number
2.3.1.9

Proteins

acetyl-CoA C-acetyltransferase
Refseq ID NP_015297
Protein GI 6325229
UniProt ID P41338
mRNA ID NM_001183842
Length 398
MSQNVYIVSTARTPIGSFQGSLSSKTAVELGAVALKGALAKVPELDASKDFDEIIFGNVLSANLGQAPARQVALAAGLSNHIVASTVNKVCASAMKAIILGAQSIKCGNADVVVAGGCESMTNAPYYMPAARAGAKFGQTVLVDGVERDGLNDAYDGLAMGVHAEKCARDWDITREQQDNFAIESYQKSQKSQKEGKFDNEIVPVTIKGFRGKPDTQVTKDEEPARLHVEKLRSARTVFQKENGTVTAANASPINDGAAAVILVSEKVLKEKNLKPLAIIKGWGEAAHQPADFTWAPSLAVPKALKHAGIEDINSVDYFEFNEAFSVVGLVNTKILKLDPSKVNVYGGAVALGHPLGCSGARVVVTLLSILQQEGGKIGVAAICNGGGGASSIVIEKI

Gene Information

Entrez Gene ID
856079
Gene Name
acetyl-CoA C-acetyltransferase
Gene Symbol
ERG10
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:SGD C cytoplasm
GO:0003985 IDA:SGD F acetyl-CoA C-acetyltransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006696 IMP:SGD P ergosterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce01110 Biosynthesis of secondary metabolites
ko00650 Butanoate metabolism
sce00650 Butanoate metabolism
M00095 C5 isoprenoid biosynthesis, mevalonate pathway
sce_M00095 C5 isoprenoid biosynthesis, mevalonate pathway
ko01200 Carbon metabolism
sce01200 Carbon metabolism
ko00071 Fatty acid degradation
sce00071 Fatty acid degradation
ko01212 Fatty acid metabolism
sce01212 Fatty acid metabolism
ko00630 Glyoxylate and dicarboxylate metabolism
sce00630 Glyoxylate and dicarboxylate metabolism
ko00310 Lysine degradation
sce00310 Lysine degradation
sce01100 Metabolic pathways
ko00640 Propanoate metabolism
sce00640 Propanoate metabolism
ko00620 Pyruvate metabolism
sce00620 Pyruvate metabolism
ko00072 Synthesis and degradation of ketone bodies
sce00072 Synthesis and degradation of ketone bodies
ko00900 Terpenoid backbone biosynthesis
sce00900 Terpenoid backbone biosynthesis
ko00380 Tryptophan metabolism
sce00380 Tryptophan metabolism
ko00280 Valine, leucine and isoleucine degradation
sce00280 Valine, leucine and isoleucine degradation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
ACETOACETATE-DEG-PWY acetoacetate degradation (to acetyl CoA)
PWY-5177 glutaryl-CoA degradation
PWY-922 mevalonate pathway
PWY-922 mevalonate pathway I
ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis
ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis I
PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
PWY-5327 superpathway of lysine degradation
TRYPTOPHAN-DEGRADATION-1 tryptophan degradation III (eukaryotic)

REACTOME Pathway Links

REACTOME Pathway ID Description
5618049 Branched-chain amino acid catabolism
5618090 Fatty acid, triacylglycerol, and ketone body metabolism
5618089 Ketone body metabolism
5618023 Metabolism
5618041 Metabolism of amino acids and derivatives
5618091 Metabolism of lipids and lipoproteins
5618088 Synthesis of Ketone Bodies
5618096 Utilization of Ketone Bodies

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA C-acetyltransferase
Protein Entry
THIL_YEAST
UniProt ID
P41338
Species
Yeast (S288c)

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=0.16 mM for CoA {ECO:0000269|PubMed:5571829}; KM=0.35 mM for acetoacetyl-CoA {ECO:0000269|PubMed:5571829}; pH dependence: Optimum pH is 8.8. {ECO:0000269|PubMed:5571829};
Biophysicochemical Properties Kinetic parameters: KM=0.16 mM for CoA ; KM=0.35 mM for acetoacetyl-CoA ; pH dependence: Optimum pH is 8.8. ;
Catalytic Activity 2 acetyl-CoA = CoA + acetoacetyl-CoA
Catalytic Activity 2 acetyl-CoA = CoA + acetoacetyl-CoA. {ECO:0000255|PROSITE-ProRule:PRU10020}.
Function Catalyzes the formation of acetoacetyl-CoA in the biosynthesis of mevalonate, an intermediate required for the biosynthesis of sterols and nonsterol isoprenoids.
Induction Induced by low intracellular sterol levels
Induction Induced by low intracellular sterol levels. {ECO:0000269|PubMed:8754796}.
Miscellaneous Present with 60895 molecules/cell in log phase SD medium
Miscellaneous Present with 60895 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.
Similarity Belongs to the thiolase family
Similarity Belongs to the thiolase family. {ECO:0000305}.
Subcellular Location Cytoplasm.
Subunit Multimeric.

Identical and Related Proteins

Unique RefSeq proteins for LMP006947 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6325229 RefSeq NP_015297 398 acetyl-CoA C-acetyltransferase

Identical Sequences to LMP006947 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006947 proteins

Reference Database Accession Length Protein Name