Gene/Proteome Database (LMPD)

LMPD ID
LMP006938
Gene ID
851414
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
biotin--[acetyl-CoA-carboxylase] ligase BPL1
Gene Symbol
BPL1
Synonyms
ACC2
Chromosome
IV
EC Number
6.3.4.-

Proteins

biotin--[acetyl-CoA-carboxylase] ligase BPL1
Refseq ID NP_010140
Protein GI 6320060
UniProt ID P48445
mRNA ID NM_001180201
Length 690
MNVLVYNGPGTTPGSVKHAVESLRDFLEPYYAVSTVNVKVLQTEPWMSKTSAVVFPGGADLPYVQACQPIISRLKHFVSKQGGVFIGFCAGGYFGTSRVEFAQGDPTMEVSGSRDLRFFPGTSRGPAYNGFQYNSEAGARAVKLNLPDGSQFSTYFNGGAVFVDADKFDNVEILATYAEHPDVPSSDSGKGQSENPAAVVLCTVGRGKVLLTGPHPEFNVRFMRKSTDKHFLETVVENLKAQEIMRLKFMRTVLTKTGLNCNNDFNYVRAPNLTPLFMASAPNKRNYLQEMENNLAHHGMHANNVELCSELNAETDSFQFYRGYRASYDAASSSLLHKEPDEVPKTVIFPGVDEDIPPFQYTPNFDMKEYFKYLNVQNTIGSLLLYGEVVTSTSTILNNNKSLLSSIPESTLLHVGTIQVSGRGRGGNTWINPKGVCASTAVVTMPLQSPVTNRNISVVFVQYLSMLAYCKAILSYAPGFSDIPVRIKWPNDLYALSPTYYKRKNLKLVNTGFEHTKLPLGDIEPAYLKISGLLVNTHFINNKYCLLLGCGINLTSDGPTTSLQTWIDILNEERQQLHLDLLPAIKAEKLQALYMNNLEVILKQFINYGAAEILPSYYELWLHSNQIVTLPDHGNTQAMITGITEDYGLLIAKELVSGSSTQFTGNVYNLQPDGNTFDIFKSLIAKKVQS

Gene Information

Entrez Gene ID
851414
Gene Name
biotin--[acetyl-CoA-carboxylase] ligase BPL1
Gene Symbol
BPL1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004077 IMP:SGD F biotin-[acetyl-CoA-carboxylase] ligase activity
GO:0004078 IEA:UniProtKB-EC F biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
GO:0004079 IEA:UniProtKB-EC F biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
GO:0004080 IEA:UniProtKB-EC F biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
GO:0071734 IDA:SGD F biotin-[pyruvate-carboxylase] ligase activity
GO:0009305 IDA:SGD P protein biotinylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00780 Biotin metabolism
sce00780 Biotin metabolism
sce01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY0-1264 biotin-carboxyl carrier protein assembly

REACTOME Pathway Links

REACTOME Pathway ID Description
5618669 Biotin transport and metabolism
5618374 Defective AMN causes hereditary megaloblastic anemia 1
5618384 Defective BTD causes biotidinase deficiency
5618383 Defective CD320 causes methylmalonic aciduria
5618375 Defective CUBN causes hereditary megaloblastic anemia 1
5618372 Defective GIF causes intrinsic factor deficiency
5618386 Defective HLCS causes multiple carboxylase deficiency
5618373 Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
5618381 Defective MMAA causes methylmalonic aciduria type cblA
5618378 Defective MMAB causes methylmalonic aciduria type cblB
5618380 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
5618379 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
5618377 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
5618376 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
5618382 Defective MUT causes methylmalonic aciduria mut type
5618369 Defective TCN2 causes hereditary megaloblastic anemia
5618385 Defects in biotin (Btn) metabolism
5618370 Defects in cobalamin (B12) metabolism
5618371 Defects in vitamin and cofactor metabolism
5618026 Disease
5618023 Metabolism
5618368 Metabolism of vitamins and cofactors
5618367 Metabolism of water-soluble vitamins and cofactors

Domain Information

InterPro Annotations

Accession Description
IPR003142 Biotin protein ligase, C-terminal
IPR004408 Biotin--acetyl-CoA-carboxylase ligase
IPR019197 Biotin-prot_ligase_N
IPR004143 Biotin/lipoate A/B protein ligase
IPR029062 Class I glutamine amidotransferase-like

UniProt Annotations

Entry Information

Gene Name
biotin--[acetyl-CoA-carboxylase] ligase BPL1
Protein Entry
BPL1_YEAST
UniProt ID
P48445
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + biotin + apo-[3-methylcrotonoyl- CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3- methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)].
Catalytic Activity ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon- dioxide ligase (ADP-forming)].
Catalytic Activity ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] = AMP + diphosphate + [methylmalonyl- CoA:pyruvate carboxytransferase].
Catalytic Activity ATP + biotin + apo-[propionyl-CoA:carbon- dioxide ligase (ADP-forming)] = AMP + diphosphate + [propionyl- CoA:carbon-dioxide ligase (ADP-forming)].
Function Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.
Miscellaneous Present with 1970 molecules/cell in log phase SD medium
Miscellaneous Present with 1970 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the biotin--protein ligase family
Similarity Belongs to the biotin--protein ligase family. {ECO:0000305}.
Similarity Contains 1 BPL/LPL catalytic domain
Similarity Contains 1 BPL/LPL catalytic domain. {ECO:0000255|PROSITE-ProRule:PRU01067}.
Subcellular Location Cytoplasm .
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14562095}.
Subunit Monomer
Subunit Monomer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006938 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320060 RefSeq NP_010140 690 biotin--[acetyl-CoA-carboxylase] ligase BPL1

Identical Sequences to LMP006938 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006938 proteins

Reference Database Accession Length Protein Name