LIPID MAPS

LMPD ID

LMP006925

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Gene Symbol

PIS1

Synonyms

-

Chromosome

XVI

EC Number

2.7.8.11

CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Refseq ID	NP_015438
Protein GI	6325370
UniProt ID	P06197
mRNA ID	NM_001184210
Length	220
MSSNSTPEKVTAEHVLWYIPNKIGYVRVITAALSFFVMKNHPTAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTAGLMCFLCVQYPQWCVFFQLMLGLDITSHYMHMYASLSAGKTSHKSVGEGESRLLHLYYTRRDVLFTICAFNELFYAGLYLQLFSNSATFGKWTTIISFPGYVFKQTANVVQLKRAALILADNDAKNANEKNKTY

Entrez Gene ID

Gene Name

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Gene Symbol

PIS1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005794	IDA:SGD	C	Golgi apparatus
GO:0005783	IEA:UniProtKB-KW	C	endoplasmic reticulum
GO:0016021	IDA:SGD	C	integral component of membrane
GO:0005741	IDA:SGD	C	mitochondrial outer membrane
GO:0003881	IDA:SGD	F	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
GO:0006661	IDA:SGD	P	phosphatidylinositol biosynthetic process

KEGG Pathway ID	Description
ko00564	Glycerophospholipid metabolism
sce00564	Glycerophospholipid metabolism
ko00562	Inositol phosphate metabolism
sce00562	Inositol phosphate metabolism
sce01100	Metabolic pathways
ko04070	Phosphatidylinositol signaling system
sce04070	Phosphatidylinositol signaling system

BIOCYC Pathway ID	Description
PWY-6352	3-phosphoinositide biosynthesis
PWY-6351	D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PWY-6351	D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PWY3O-242	phosphatidylinositol phosphate biosynthesis
PWY-6371	superpathway of inositol phosphate compounds

REACTOME Pathway ID	Description
5618125	Glycerophospholipid biosynthesis
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618126	Phospholipid metabolism
5618598	Synthesis of PI

Accession	Description
IPR000462	CDP-alcohol phosphatidyltransferase
IPR014387	CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote

Gene Name

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Protein Entry

PIS_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol.
Miscellaneous	Myo-inositol-containing phospholipids are of crucial importance in the control of cellular functions.
Miscellaneous	Present with 3810 molecules/cell in log phase SD medium
Miscellaneous	Present with 3810 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Similarity	Belongs to the CDP-alcohol phosphatidyltransferase class-I family. {ECO:0000305}.
Subcellular Location	Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane.