LIPID MAPS

LMPD ID

LMP006921

Gene ID

854815

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

phosphoinositide 5-phosphatase INP51

Gene Symbol

INP51

Synonyms

SJL1

Chromosome

IX

EC Number

3.1.3.36

phosphoinositide 5-phosphatase INP51
Refseq ID	NP_012264
Protein GI	398364541
UniProt ID	P40559
mRNA ID	NM_001179352
Length	946
MRLFIGRRSRSIVISSNNYCLSFQRLRSIPGASSQQRQLSKTPSVTIKSYPDTDLSSDSNYLEVKSCIFNGLLGLVCLNGDIYVAVISGVQNVGFPRWKLIDHQVRPSESIYKVLDVDFYSLENDVFDYLLCERSEQNYDKLIHEHPCGPLKKLFSDGTFYYSRDFDISNIVKNHGLSHNLEYTVDNQDLSFIWNANLASEVINWRSKISNEEKQLFANAGFLTFVIRGYCKTALIEDGPNTASITIISRISTESKQDTLELEGISEDGRVSLFVETEIVVTTEKFIFSYTQVNGSIPLFWESVESQLLYGKKIKVTKDSIEAQGAFDRHFDNLTSKYGVVSIVNIIKPKSESQEKLALTYKDCAESKGIKITNIEYSSSVLTKSPHKLLYLLKQDIYEFGAFAYDISRGIYFAKQTGVLRISAFDSIEKPNTVERLVSKEVLELTTNEIDVFELTSPFLDAHDKLWSENYYWLDRTYTKHTKNSGKYTKVYSKLFGSRVRLYDPLHIYISQYLKQLRSKYTFEKDISIFAGTFNISGKIPKDDIKDWIFPKSMSKEDEMADLYVIGLEEVVELTPGHMLATDPYVRQFWEKKILTLLNGPGRKKKYIRLWSTQLGGILLLLFMNETEYSKVKHIEGDVKKTGFGGMASNKGAVAVSFKYSATRFCVLVSHLAAGLENVEQRHNDYKTIAKSIRFSKGLRIKDHDAIIWMGDFNYRILMSNEDVRRKIVSKEYASLFEKDQLNQQMIAGESFPYFHEMAIDFPPTYKFDPGTKNYDTSEKMRIPAWTDRILSRGEVLEQLEYKCCEDILFSDHRPVYAIFRARVTVVDEQKKTTLGTQIYEKIMERLEGLDDDEKIAVLSDDAFVIESFEGSDSIAGPTHSPTPIPEPKRGRKLPPPSSDLKKWWIGSGKQVKVVLDVDPAVYMINPKRDPNPFVENEDEPLFIER

Entrez Gene ID

854815

Gene Name

phosphoinositide 5-phosphatase INP51

Gene Symbol

INP51

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:SGD	C	cytoplasm
GO:0005856	IEA:UniProtKB-KW	C	cytoskeleton
GO:0016020	IDA:SGD	C	membrane
GO:0004439	IDA:SGD	F	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0006897	IEA:UniProtKB-KW	P	endocytosis
GO:0046856	IDA:SGD	P	phosphatidylinositol dephosphorylation
GO:0015031	IEA:UniProtKB-KW	P	protein transport

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY3O-242	phosphatidylinositol phosphate biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
5618626	Inositol phosphate metabolism
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618611	PI Metabolism
5618126	Phospholipid metabolism
5618625	Synthesis of IP2, IP, and Ins in the cytosol
5618629	Synthesis of IP3 and IP4 in the cytosol
5618610	Synthesis of PIPs at the plasma membrane

InterPro Annotations

Accession	Description
IPR005135	Endonuclease/exonuclease/phosphatase
IPR000300	Inositol polyphosphate-related phosphatase
IPR002013	SAC domain

Entry Information

Gene Name

phosphoinositide 5-phosphatase INP51

Protein Entry

INP51_YEAST

UniProt ID

P40559

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Enzyme Regulation	IRS4 and TAX4 are both positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover
Enzyme Regulation	IRS4 and TAX4 are both positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. {ECO:0000269\|PubMed:15265867}.
Function	Controls the cellular levels and subcellular distribution of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Does not utilize phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth. {ECO:0000269\|PubMed:11311145, ECO:0000269\|PubMed:15265867, ECO:0000269\|PubMed:15689497, ECO:0000269\|PubMed:15691741, ECO:0000269\|PubMed:17452534, ECO:0000269\|PubMed:9265642, ECO:0000269\|PubMed:9560389, ECO:0000269\|PubMed:9788876}.
Interaction	P36115:IRS4; NbExp=3; IntAct=EBI-24915, EBI-27090; P47030:TAX4; NbExp=3; IntAct=EBI-24915, EBI-25970;
Miscellaneous	Present with 98 molecules/cell in log phase SD medium
Miscellaneous	Present with 98 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the synaptojanin family
Similarity	Belongs to the synaptojanin family. {ECO:0000305}.
Similarity	Contains 1 SAC domain. {ECO:0000255\|PROSITE- ProRule:PRU00183}.
Similarity	In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family
Similarity	In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. {ECO:0000305}.
Subcellular Location	Cytoplasm, cytoskeleton, actin patch .
Subcellular Location	Cytoplasm, cytoskeleton, actin patch {ECO:0000269\|PubMed:14562095}.
Subunit	Interacts with IRS4 and TAX4
Subunit	Interacts with IRS4 and TAX4. {ECO:0000269\|PubMed:15265867}.