LIPID MAPS

LMPD ID

LMP006911

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Hfd1p

Gene Symbol

HFD1

Synonyms

-

Alternate Names

Hfd1p

Chromosome

XIII

EC Number

1.2.1.3

Hfd1p
Refseq ID	NP_013828
Protein GI	6323757
UniProt ID	Q04458
mRNA ID	NM_001182610
Length	532
RefSeq Status	PROVISIONAL
MSNDGSKILNYTPVSKIDEIVEISRNFFFEKQLKLSHENNPRKKDLEFRQLQLKKLYYAVKDHEEELIDAMYKDFHRNKIESVLNETTKLMNDILHLIEILPKLIKPRRVSDSSPPFMFGKTIVEKISRGSVLIIAPFNFPLLLAFAPLAAALAAGNTIVLKPSELTPHTAVVMENLLTTAGFPDGLIQVVQGAIDETTRLLDCGKFDLIFYTGSPRVGSIVAEKAAKSLTPCVLELGGKSPTFITENFKASNIKIALKRIFFGAFGNSGQICVSPDYLLVHKSIYPKVIKECESVLNEFYPSFDEQTDFTRMIHEPAYKKAVASINSTNGSKIVPSKISINSDTEDLCLVPPTIVYNIGWDDPLMKQENFAPVLPIIEYEDLDETINKIIEEHDTPLVQYIFSDSQTEINRILTRLRSGDCVVGDTVIHVGITDAPFGGIGTSGYGNYGGYYGFNTFSHERTIFKQPYWNDFTLFMRYPPNSAQKEKLVRFAMERKPWFDRNGNNKWGLRQYFSLSAAVILISTIYAHCSS

Entrez Gene ID

Gene Name

Hfd1p

Gene Symbol

HFD1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005768	IEA:UniProtKB-KW	C	endosome
GO:0031307	IDA:SGD	C	integral component of mitochondrial outer membrane
GO:0005811	IDA:SGD	C	lipid particle
GO:0004028	ISS:SGD	F	3-chloroallyl aldehyde dehydrogenase activity
GO:0004029	IEA:UniProtKB-EC	F	aldehyde dehydrogenase (NAD) activity
GO:0004030	IEA:InterPro	F	aldehyde dehydrogenase [NAD(P)+] activity
GO:0047770	IMP:SGD	F	carboxylate reductase activity
GO:0006081	IMP:SGD	P	cellular aldehyde metabolic process

Accession	Description
IPR016162	Aldehyde dehydrogenase N-terminal domain
IPR012394	Aldehyde dehydrogenase NAD(P)-dependent
IPR015590	Aldehyde dehydrogenase domain
IPR016163	Aldehyde dehydrogenase, C-terminal
IPR029510	Aldehyde dehydrogenase, glutamic acid active site
IPR016161	Aldehyde/histidinol dehydrogenase

Gene Name

Hfd1p

Protein Entry

HFD1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Function	Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. {ECO:0000269\|PubMed:22633490}.
Miscellaneous	Present with 2930 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the aldehyde dehydrogenase family. {ECO:0000305}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endosome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasmic granule membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Protein GI	Database	Accession	Length	Protein Name
6323757	RefSeq	NP_013828	532	Hfd1p

Reference	Database	Accession	Length	Protein Name
GI:6323757	EMBL	CAY81929.1	532	Hfd1p [Saccharomyces cerevisiae EC1118]
GI:6323757	GenBank	EHN05357.1	532	Hfd1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6323757	GenBank	EIW08371.1	532	Hfd1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6323757	GenBank	EWG89394.1	532	Hfd1p [Saccharomyces cerevisiae P301]
GI:6323757	gnl	McCuskerlabDuke	532	Hfd1p [Saccharomyces cerevisiae YJM993]
GI:6323757	Third Party Genbank	DAA10007.1	532	TPA: Hfd1p [Saccharomyces cerevisiae S288c]

Reference	Database	Accession	Length	Protein Name
GI:6323757	DBBJ	GAA25553.1	532	K7_Hfd1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6323757	GenBank	EDN64497.1	532	conserved protein [Saccharomyces cerevisiae YJM789]
GI:6323757	GenBank	EGA81464.1	532	Hfd1p [Saccharomyces cerevisiae Lalvin QA23]
GI:6323757	GenBank	EHN00834.1	532	Hfd1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6323757	GenBank	EWG84032.1	532	Hfd1p [Saccharomyces cerevisiae R008]
GI:6323757	GenBank	EWG94055.1	532	Hfd1p [Saccharomyces cerevisiae R103]