LIPID MAPS

LMPD ID

LMP006909

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

acetolactate synthase regulatory subunit

Gene Symbol

ILV6

Synonyms

-

Chromosome

III

acetolactate synthase regulatory subunit
Refseq ID	NP_009918
Protein GI	6319837
UniProt ID	P25605
mRNA ID	NM_001178658
Length	309
MLRSLLQSGHRRVVASSCATMVRCSSSSTSALAYKQMHRHATRPPLPTLDTPSWNANSAVSSIIYETPAPSRQPRKQHVLNCLVQNEPGVLSRVSGTLAARGFNIDSLVVCNTEVKDLSRMTIVLQGQDGVVEQARRQIEDLVPVYAVLDYTNSEIIKRELVMARISLLGTEYFEDLLLHHHTSTNAGAADSQELVAEIREKQFHPANLPASEVLRLKHEHLNDITNLTNNFGGRVVDISETSCIVELSAKPTRISAFLKLVEPFGVLECARSGMMALPRTPLKTSTEEAADEDEKISEIVDISQLPPG

Entrez Gene ID

Gene Name

acetolactate synthase regulatory subunit

Gene Symbol

ILV6

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005948	IDA:SGD	C	acetolactate synthase complex
GO:0042645	IDA:SGD	C	mitochondrial nucleoid
GO:0003984	IDA:SGD	F	acetolactate synthase activity
GO:0016597	IEA:InterPro	F	amino acid binding
GO:0030234	IDA:SGD	F	enzyme regulator activity
GO:0009082	IDA:SGD	P	branched-chain amino acid biosynthetic process
GO:0009097	IEA:UniProtKB-UniPathway	P	isoleucine biosynthetic process
GO:0050790	IDA:GOC	P	regulation of catalytic activity
GO:0009099	IEA:UniProtKB-UniPathway	P	valine biosynthetic process

KEGG Pathway ID	Description
ko01210	2-Oxocarboxylic acid metabolism
sce01210	2-Oxocarboxylic acid metabolism
ko01230	Biosynthesis of amino acids
sce01230	Biosynthesis of amino acids
sce01110	Biosynthesis of secondary metabolites
ko00650	Butanoate metabolism
sce00650	Butanoate metabolism
ko00660	C5-Branched dibasic acid metabolism
sce00660	C5-Branched dibasic acid metabolism
M00570	Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine
sce_M00570	Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine
sce01100	Metabolic pathways
ko00770	Pantothenate and CoA biosynthesis
sce00770	Pantothenate and CoA biosynthesis
ko00290	Valine, leucine and isoleucine biosynthesis
sce00290	Valine, leucine and isoleucine biosynthesis
M00019	Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine
sce_M00019	Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine

BIOCYC Pathway ID	Description
PWY3O-335	acetoin biosynthesis I
ILEUSYN-PWY	isoleucine biosynthesis
PWY3O-981	superpathway of acetoin and butanediol biosynthesis
BRANCHED-CHAIN-AA-SYN-PWY	superpathway of leucine, valine, and isoleucine biosynthesis
VALSYN-PWY	valine biosynthesis

Gene Name

acetolactate synthase regulatory subunit

Protein Entry

ILV6_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Function	Stimulates activity of the acetolactate synthase catalytic subunit ILV2 seven- to tenfold and confers sensitivity to inhibition by valine and activation by ATP
Function	Stimulates activity of the acetolactate synthase catalytic subunit ILV2 seven- to tenfold and confers sensitivity to inhibition by valine and activation by ATP. {ECO:0000269\|PubMed:10213630}.
Interaction	Self; NbExp=1; IntAct=EBI-9087, EBI-9087; P10592:SSA2; NbExp=1; IntAct=EBI-9087, EBI-8603;
Miscellaneous	Present with 15800 molecules/cell in log phase SD medium
Miscellaneous	Present with 15800 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate: step 1/4.
Pathway	Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.
Similarity	Belongs to the acetolactate synthase small subunit family
Similarity	Belongs to the acetolactate synthase small subunit family. {ECO:0000305}.
Similarity	Contains 1 ACT domain. {ECO:0000255\|PROSITE- ProRule:PRU01007}.
Subcellular Location	Mitochondrion.
Subunit	The acetolactate synthase complex contains the catalytic regulatory subunit ILV2 and the regulatory small subunit ILV6.