Gene/Proteome Database (LMPD)
Proteins
| Tsc11p | |
|---|---|
| Refseq ID | NP_011018 |
| Protein GI | 6320939 |
| UniProt ID | P40061 |
| mRNA ID | NM_001178984 |
| Length | 1430 |
| RefSeq Status | PROVISIONAL |
| MSIPHSAKQSSPLSSRRRSVTNTTPLLTPRHSRDNSSTQISSAKNITSSSPSTITNESSKRNKQNLVLSTSFISTKRLENSAPSPTSPLMARRTRSTMTKALLNLKAEINNQYQELARLRKKKDDIEHLRDSTISDIYSGSYSTNHLQKHSMRIRANTQLREIDNSIKRVEKHIFDLKQQFDKKRQRSLTTSSSIKADVGSIRNDDGQNNDSEELGDHDSLTDQVTLDDEYLTTPTSGTERNSQQNLNRNSTVNSRNNENHSTLSIPDLDGSNKVNLTGDTEKDLGDLENENQIFTSTTTEAATWLVSDYMQSFQEKNVNPDFIAQKANGLVTLLKEHSEIRKDLVLTSFMSSIQNLLLNGNKLIAASAYRVCRYLINSSIFIDELLELRLDAFIIISLAKDNSFQIEREQALKMVRRFIEYNNGVTQGIMQAIISCVEKPEDSLRHMALETLLELCFVAPEMVKECRGMRVIEGFLQDYTSFSLASVILDTILQLMATHKTRQHFLEDFNVSVLTTVFSDTNTKSNVNVEKMQNASTLISITLNSYNGFMLFSNNNFKPLKQLVSFFQIPICAQYLIDIFLDVLKIKPLPYKPRGRHSHSFKPIPSQYYKECMSVNQRLALIVLILENSEFVPHLLELLNEEDRDDHLVAKGRYLLTEYFNLRMNLVDKKYTSVSKPIYKENFTYVNETFQFKKIAYKMNRNRNTIGMSGIDYAQNIKSFSKNIKENTLLREVDDFRFRRMVYDSKVLQTKDFTRWNWNIINELLEGPLLNKKQLEELVKSTKFIRRLLVFYRPLRLRFSNVNKGAKLSQKYVQVGCQFFKTLTATPEGMKILMDDTKIIPQLASLMFRAMEGNISGNIFNKNKLREKIIFGYFKFIGILTQSKNGVHILTRWNFFTVIYKMFQFESKLGLEFLLLTIPELDLKYSSHCRVIIGKALVVANEKVRIEATKHIGDKLKELLSTKESDLKLKANKVKLQQFKMEMLTRQLYDLSPSVVAVADQALYECIVAGNGSEELGTSFRMFLNQMVFIRSPILFELLSRPYGFQLLNEINFVKEERDSWLSKKNIEYVHIVEEFLKKNESINAKSLTFQQKSRLPLHFYESLTKTEDGILLLSQTGDLVTFMNVIKKYVNGNNMATVENAKEILDLKAALWCVGFIGSTELGIGLLDNYSLVEDIIEVAYNASVTSVRFTAFYVLGLISMTREGCEILDEMGWNCCVSVQDEPIGIALPNRLDRFLSYNEHKWSAFGEYSDEMIVFNKSDGDLIEKCLPIEFDLDKLLKEKDTAENPLNEKIITNKYDNDITSQTITVSGENSSLFANEGLSSPYVTQYRNDDDSIESKVLHIVSQLGNHILSNHAVKEITEINNKYGPRLFENEKMFFKVFNMMSKYRFKPHVRKFLCGLFINNRALENVIRHDNKRDKRPANFTR | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031932 | IPI:SGD | C | TORC2 complex |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0005773 | IEA:UniProtKB-KW | C | vacuole |
| GO:0005085 | IEA:UniProtKB-KW | F | guanyl-nucleotide exchange factor activity |
| GO:0031929 | IC:SGD | P | TOR signaling |
| GO:0030950 | IMP:SGD | P | establishment or maintenance of actin cytoskeleton polarity |
| GO:0031505 | IMP:SGD | P | fungal-type cell wall organization |
| GO:0001558 | IPI:SGD | P | regulation of cell growth |
| GO:0030148 | IGI:SGD | P | sphingolipid biosynthetic process |
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR011989 | Armadillo-like helical |
| IPR016024 | Armadillo-type fold |
| IPR028268 | Pianissimo family |
| IPR028267 | Rapamycin-insensitive companion of mTOR, N-terminal domain |
| IPR029453 | Rapamycin-insensitive companion of mTOR, domain 4 |
| IPR029452 | Rapamycin-insensitive companion of mTOR, domain 5 |
| IPR029451 | Rapamycin-insensitive companion of mTOR, middle domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Function | Essential component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. TSC11 may exert its functions through two distinct mechanisms, one mediated by AVO1 and the other mediated by AVO2 and SLM1. {ECO:0000269|PubMed:15809876}. |
| Interaction | P41318:LST8; NbExp=2; IntAct=EBI-22621, EBI-28598; P32600:TOR2; NbExp=5; IntAct=EBI-22621, EBI-19385; |
| Miscellaneous | Present with 1840 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Ptm | Phosphorylated by TOR2; when part of TORC2. {ECO:0000269|PubMed:16002396, ECO:0000269|PubMed:17330950, ECO:0000269|PubMed:18407956, ECO:0000269|PubMed:19779198}. |
| Similarity | Belongs to the pianissimo family. {ECO:0000305}. |
| Similarity | Contains 1 N-terminal Ras-GEF domain. {ECO:0000305}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12631735}; Peripheral membrane protein {ECO:0000269|PubMed:12631735}; Cytoplasmic side {ECO:0000269|PubMed:12631735}. Vacuole membrane {ECO:0000269|PubMed:12631735}; Peripheral membrane protein {ECO:0000269|PubMed:12631735}; Cytoplasmic side {ECO:0000269|PubMed:12631735}. |
| Subunit | The target of rapamycin complex 2 (TORC2) is composed of at least AVO1, AVO2, BIT61, LST8, TOR2 and TSC11. TORC2 likely forms a homodimer. Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP-rapamycin. TSC11 binds to the N-terminal HEAT repeat region in TOR2 and is required for TORC2 integrity by tethering AVO1 and AVO2 to the complex. {ECO:0000269|PubMed:12408816, ECO:0000269|PubMed:12631735, ECO:0000269|PubMed:16002396}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006901 (as displayed in Record Overview)
Identical Sequences to LMP006901 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6320939 | GenBank | AAB64648.1 | 1430 | Yer093cp [Saccharomyces cerevisiae] |
| GI:6320939 | GenBank | EEU06518.1 | 1430 | Tsc11p [Saccharomyces cerevisiae JAY291] |
| GI:6320939 | SwissProt | P40061.1 | 1430 | RecName: Full=Target of rapamycin complex 2 subunit TSC11; Short=TORC2 subunit TSC11; AltName: Full=Adheres voraciously to TOR2 protein 3; AltName: Full=Temperature-sensitive CSG2 suppressor protein 11 [Saccharomyces cerevisiae S288c] |
| GI:6320939 | Third Party Genbank | DAA07754.1 | 1430 | TPA: Tsc11p [Saccharomyces cerevisiae S288c] |
Related Sequences to LMP006901 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6320939 | EMBL | CAY79277.1 | 1430 | Tsc11p [Saccharomyces cerevisiae EC1118] |
| GI:6320939 | GenBank | EWG86593.1 | 1430 | Tsc11p [Saccharomyces cerevisiae R008] |
| GI:6320939 | GenBank | EWG91488.1 | 1430 | Tsc11p [Saccharomyces cerevisiae P301] |
| GI:6320939 | GenBank | EWG96513.1 | 1430 | Tsc11p [Saccharomyces cerevisiae R103] |
| GI:6320939 | GenBank | EWH18842.1 | 1430 | Tsc11p [Saccharomyces cerevisiae P283] |
| GI:6320939 | gnl | McCuskerlabDuke | 1430 | Tsc11p [Saccharomyces cerevisiae YJM993] |