Gene/Proteome Database (LMPD)

LMPD ID
LMP006889
Gene ID
854089
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
phosphoinositide 5-phosphatase INP54
Gene Symbol
INP54
Synonyms
-
Alternate Names
phosphoinositide 5-phosphatase INP54
Chromosome
XV
EC Number
3.1.3.36

Proteins

phosphoinositide 5-phosphatase INP54
Refseq ID NP_014576
Protein GI 6324507
UniProt ID Q08227
mRNA ID NM_001183320
Length 384
RefSeq Status PROVISIONAL
MNKTNWKVSVTTFNCGKEFPVENSKAIVKQLLFPYDDGISQLELQDLYVLGFQEVVPIWQGSFPAVNRDLIDRITTTAVNCLNEKVSATQGDEQYSCLGVNSLGAITIIVLYNNNALKVKDDILKRNGKCGWFGTHLKGGTLISFQMTRNGEENWERFSYICAHLNANEGVNNRNQRIDDYKRIMSEVCDSEVAKSDHFFFLGDLNFRVTSTYDPTTNYSSTTTLRRLLENHEELNLLRKGEDEPLCKGFQELKITFPPTYKFKLFEKETYNTKRIPSWCDRILYKSYAVPTFAQEGTYHSVPRSNALLFSDHQPVNLTVRLPRSTGTPVPLSLHIEKYPLSWSSGLIGQIGDAVIGYCGWLVTKNVHYWILGSLLLYLLLKIL

Gene Information

Entrez Gene ID
854089
Gene Name
phosphoinositide 5-phosphatase INP54
Gene Symbol
INP54
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0004439 IDA:SGD F phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0046856 IDA:SGD P phosphatidylinositol dephosphorylation
GO:0015031 IEA:UniProtKB-KW P protein transport

KEGG Pathway Links

KEGG Pathway ID Description
sce00562 Inositol phosphate metabolism
sce01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis
PWY3O-242 phosphatidylinositol phosphate biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase
IPR000300 Inositol polyphosphate-related phosphatase

UniProt Annotations

Entry Information

Gene Name
phosphoinositide 5-phosphatase INP54
Protein Entry
INP54_YEAST
UniProt ID
Q08227
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Function Regulates the phosphatidylinositol (4,5)-diphosphate levels on the cytoplasmic surface of the endoplasmic reticulum and thereby regulates secretion. Does not utilize phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3- phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). {ECO:0000269|PubMed:10660045, ECO:0000269|PubMed:11116155}.
Miscellaneous Present with 1200 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:11116155}; Peripheral membrane protein {ECO:0000269|PubMed:11116155}; Cytoplasmic side {ECO:0000269|PubMed:11116155}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006889 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324507 RefSeq NP_014576 384 phosphoinositide 5-phosphatase INP54

Identical Sequences to LMP006889 proteins

Reference Database Accession Length Protein Name
GI:6324507 EMBL CAA99075.1 384 unnamed protein product [Saccharomyces cerevisiae]
GI:6324507 GenBank EIW07868.1 384 Inp54p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6324507 SwissProt Q08227.1 384 RecName: Full=Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP54 [Saccharomyces cerevisiae S288c]
GI:6324507 Third Party Genbank DAA10718.1 384 TPA: phosphoinositide 5-phosphatase INP54 [Saccharomyces cerevisiae S288c]

Related Sequences to LMP006889 proteins

Reference Database Accession Length Protein Name
GI:6324507 DBBJ GAA26262.1 384 K7_Inp54p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6324507 GenBank EDN63810.1 384 inositol polyphosphate 5-phosphatase [Saccharomyces cerevisiae YJM789]
GI:6324507 GenBank EGA73083.1 384 Inp54p [Saccharomyces cerevisiae AWRI796]
GI:6324507 GenBank EGA76931.1 384 Inp54p [Saccharomyces cerevisiae Vin13]
GI:6324507 GenBank EHN04717.1 384 Inp54p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6324507 gnl McCuskerlabDuke 384 Inp54p [Saccharomyces cerevisiae YJM993]