LIPID MAPS

LMPD ID

LMP006876

Gene ID

852314

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Etr1p

Gene Symbol

ETR1

Synonyms

MRF1; MRF1'

Chromosome

II

EC Number

1.3.1.10

Etr1p
Refseq ID	NP_009582
Protein GI	6319500
UniProt ID	P38071
mRNA ID	NM_001178374
Length	380
MLPTFKRYMSSSAHQIPKHFKSLIYSTHEVEDCTKVLSVKNYTPKQDLSQSIVLKTLAFPINPSDINQLQGVYPSRPEKTYDYSTDEPAAIAGNEGVFEVVSLPSGSSKGDLKLGDRVIPLQANQGTWSNYRVFSSSSDLIKVNDLDLFSAATVSVNGCTGFQLVSDYIDWNSNGNEWIIQNAGTSSVSKIVTQVAKAKGIKTLSVIRDRDNFDEVAKVLEDKYGATKVISESQNNDKTFAKEVLSKILGENARVRLALNSVGGKSSASIARKLENNALMLTYGGMSKQPVTLPTSLHIFKGLTSKGYWVTEKNKKNPQSKIDTISDFIKMYNYGHIISPRDEIETLTWNTNTTTDEQLLELVKKGITGKGKKKMVVLEW

Entrez Gene ID

852314

Gene Name

Etr1p

Gene Symbol

ETR1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005739	IDA:SGD	C	mitochondrion
GO:0003677	IEA:UniProtKB-KW	F	DNA binding
GO:0004319	IEA:UniProtKB-EC	F	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
GO:0016631	IDA:SGD	F	enoyl-[acyl-carrier-protein] reductase activity
GO:0019166	IEA:UniProtKB-EC	F	trans-2-enoyl-CoA reductase (NADPH) activity
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0009060	IMP:SGD	P	aerobic respiration
GO:0006633	IMP:SGD	P	fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID	Description
ko00062	Fatty acid elongation
sce00062	Fatty acid elongation
ko01212	Fatty acid metabolism
sce01212	Fatty acid metabolism
sce01100	Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY-7388	octanoyl-ACP biosynthesis (mitochondria)
PWY-7388	octanoyl-ACP biosynthesis (mitochondria, yeast)
PWY-5994	palmitate biosynthesis
PWY-5994	palmitate biosynthesis I (animals and fungi)

InterPro Annotations

Accession	Description
IPR002085	Alcohol dehydrogenase superfamily, zinc-type
IPR011032	GroES (chaperonin 10)-like
IPR016040	NAD(P)-binding domain

Entry Information

Gene Name

Etr1p

Protein Entry

ETR1_YEAST

UniProt ID

P38071

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
Catalytic Activity	An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.
Caution	Was originally (PubMed:8195160) thought to be a nuclear protein involved in transcriptional regulation of genes required for the functional assembly of mitochondrial respiratory proteins. This was later proven not to be the case (PubMed:11509667)
Caution	Was originally (PubMed:8195160) thought to be a nuclear protein involved in transcriptional regulation of genes required for the functional assembly of mitochondrial respiratory proteins. This was later proven not to be the case (PubMed:11509667). {ECO:0000305\|PubMed:11509667, ECO:0000305\|PubMed:8195160}.
Function	Required for respiration and the maintenance of the mitochondrial compartment. Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis
Function	Required for respiration and the maintenance of the mitochondrial compartment. Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis. {ECO:0000269\|PubMed:11509667, ECO:0000269\|PubMed:12614607}.
Miscellaneous	Present with 1560 molecules/cell in log phase SD medium
Miscellaneous	Present with 1560 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily
Similarity	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. {ECO:0000305}.
Subcellular Location	Mitochondrion matrix {ECO:0000269\|PubMed:11502169, ECO:0000269\|PubMed:11509667, ECO:0000269\|PubMed:14576278}.
Subunit	Homodimer or in a complex with other proteins. Interacts with ARS1
Subunit	Homodimer or in a complex with other proteins. Interacts with ARS1. {ECO:0000269\|PubMed:11509667}.