Gene/Proteome Database (LMPD)

LMPD ID
LMP006872
Gene ID
851580
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
inositol polyphosphate kinase KCS1
Gene Symbol
KCS1
Synonyms
-
Chromosome
IV
EC Number
2.7.4.21

Proteins

inositol polyphosphate kinase KCS1
Refseq ID NP_010300
Protein GI 398365025
UniProt ID Q12494
mRNA ID NM_001180325
Length 1050
MDTSHEIHDKIPDTLREQQQHLRQKESEGCITTLKDLNVPETKKLSSVLHGRKASTYLRIFRDDECLADNNNGVDSNNGGSVTCADKITRSEATPKSVPEGLQVSEKKNNPDTLSSSLSSFILSNHEEPAIKPNKHVAHRNNITETGQGSGEDIAKQQSHQPQVLHHQTSLKPIQNVDEGCISPKSTYQESLHGISEDLTLKPVSSATYYPHKSKADSGYEEKDKMENDIDTIQPATINCASGIATLPSSYNRHTFKVKTYSTLSQSLRQENVNNRSNEKKPQQFVPHSESIKEKPNTFEQDKEGEQADEEEDEGDNEHREYPLAVELKPFTNRVGGHTAIFRFSKRAVCKALVNRENRWYENIELCHKELLQFMPRYIGVLNVRQHFQSKDDFLSDLDQENNGKNDTSNENKDIEVNHNNNDDIALNTEPTGTPLTHIHSFPLEHSSRQVLEKEHPEIESVHPHVKRSLSSSNQPSLLPEVVLNDNRHIIPESLWYKYSDSPNSAPNDSYFSSSSSHNSCSFGERGNTNKLKRRDSGSTMINTELKNLVIREVFAPKCFRRKRNSNTTTMGNHNARLGSSPSFLTQKSRASSHDASNTSMKTLGDSSSQASLQMDDSKVNPNLQDPFLKKSLHEKISNALDGSHSVMDLKQFHKNEQIKHKNSFCNSLSPILTATNSRDDGEFATSPNYISNAQDGVFDMDEDTGNETINMDNHGCHLDSGKNMIIKSLAYNVSNDYSHHDIESITFEETSHTIVSKFILLEDLTRNMNKPCALDLKMGTRQYGVDAKRAKQLSQRAKCLKTTSRRLGVRICGLKVWNKDYYITRDKYFGRRVKVGWQFARVLARFLYDGKTIESLIRQIPRLIKQLDTLYSEIFNLKGYRLYGASLLLMYDGDANKSNSKRKKAANVKVNLIDFARCVTKEDAMECMDKFRIPPKSPNIEDKGFLRGVKSLRFYLLLIWNYLTSDMPLIFDEVEMNDMISEEADSNSFTSATGSKINFNSKWDWLDEFDKEDEEMYNDPNSKLRQKWRKYELIFDAEPRYNDDAQVSD

Gene Information

Entrez Gene ID
851580
Gene Name
inositol polyphosphate kinase KCS1
Gene Symbol
KCS1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0033200 ISS:SGD F inositol heptakisphosphate 5-kinase activity
GO:0000829 IDA:SGD F inositol heptakisphosphate kinase activity
GO:0052723 IEA:UniProtKB-EC F inositol hexakisphosphate 1-kinase activity
GO:0052724 IEA:UniProtKB-EC F inositol hexakisphosphate 3-kinase activity
GO:0000832 IEA:UniProtKB-EC F inositol hexakisphosphate 5-kinase activity
GO:0000828 IDA:SGD F inositol hexakisphosphate kinase activity
GO:0000827 IDA:SGD F inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0008440 IEA:InterPro F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0032958 IDA:SGD P inositol phosphate biosynthetic process
GO:0010919 IMP:SGD P regulation of inositol phosphate biosynthetic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3O-402 inositol phosphate biosynthesis
PWY-6369 inositol pyrophosphates biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5618626 Inositol phosphate metabolism
5618023 Metabolism
5618627 Synthesis of IPs in the nucleus
5618628 Synthesis of pyrophosphates in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate kinase KCS1
Protein Entry
KCS1_YEAST
UniProt ID
Q12494
Species
Yeast (S288c)

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=3.3 uM for InsP6 {ECO:0000269|PubMed:10827188}; KM=1.2 uM for InsP5 {ECO:0000269|PubMed:10827188}; Vmax=2 umol/min/mg enzyme {ECO:0000269|PubMed:10827188};
Biophysicochemical Properties Kinetic parameters: KM=3.3 uM for InsP6 ; KM=1.2 uM for InsP5 ; Vmax=2 umol/min/mg enzyme ;
Catalytic Activity ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
Function Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance. {ECO:0000269|PubMed:10574768, ECO:0000269|PubMed:10827188, ECO:0000269|PubMed:11956213, ECO:0000269|PubMed:15561716, ECO:0000269|PubMed:15866881, ECO:0000269|PubMed:15944147, ECO:0000269|PubMed:8601473}.
Miscellaneous Present with 1940 molecules/cell in log phase SD medium
Miscellaneous Present with 1940 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the inositol phosphokinase (IPK) family
Similarity Belongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular Location Cytoplasm .
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14562095}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006872 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398365025 RefSeq NP_010300 1050 inositol polyphosphate kinase KCS1

Identical Sequences to LMP006872 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006872 proteins

Reference Database Accession Length Protein Name