LIPID MAPS

LMPD ID

LMP006870

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Nus1p

Gene Symbol

NUS1

Synonyms

-

Alternate Names

Nus1p

Chromosome

IV

EC Number

2.5.1.87

Nus1p
Refseq ID	NP_010088
Protein GI	6320008
UniProt ID	Q12063
mRNA ID	NM_001180253
Length	375
RefSeq Status	PROVISIONAL
MPTMIKKDDKAMEPPNEKPHRKIERDDVPESSNHIPPPESGVLKGGKVNSKTRALKAVTSIIADADENPQKKVNNETNGVQKQKTEDLSKRIGKFEYLFYKFLLVLLYICFGLFRYGQYQYNKMKLRIFSIIYNHAYTPQLIRQDVIPLKKIPKRLAAILEVKPVGDVGGGVTGLLNDASEIVCWTVSAGIKHLMLYDYDGILQRNVPELRMEIHSNLAKYFGPAHVPNYAVKIPHSNKIFYNLDGIETETDVGNEIEANQEKDKIAIEISLLSNRDGRETIVDLTKTMAELCAVNELSVSDITMDLVDSELKQLVGPEPDLLLYFGPSLDLQGFPPWHIRLTEFYWEKDNNEVIYSVFIRGLRQYAGCKVNVGK

Entrez Gene ID

Gene Name

Nus1p

Gene Symbol

NUS1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005783	IDA:SGD	C	endoplasmic reticulum
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005811	IDA:SGD	C	lipid particle
GO:0005634	IEA:UniProtKB-KW	C	nucleus
GO:0008834	IEA:UniProtKB-EC	F	di-trans,poly-cis-decaprenylcistransferase activity
GO:0006486	IMP:SGD	P	protein glycosylation

Accession	Description
IPR001441	Decaprenyl diphosphate synthase-like

Gene Name

Nus1p

Protein Entry

UPPS_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55). {ECO:0000269\|PubMed:25066056}.
Function	With SRT1 or RER2, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). {ECO:0000269\|PubMed:25066056}.
Pathway	Protein modification; protein glycosylation. {ECO:0000305}.
Similarity	Belongs to the UPP synthase family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Lipid droplet {ECO:0000269\|PubMed:10515935, ECO:0000269\|PubMed:11086160, ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:14690591}. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Subunit	Forms an active dehydrodolichyl diphosphate syntase complex with either SRT1 or RER2. {ECO:0000303\|PubMed:25066056}.

Protein GI	Database	Accession	Length	Protein Name
6320008	RefSeq	NP_010088	375	Nus1p

Reference	Database	Accession	Length	Protein Name
GI:6320008	EMBL	CAA58254.1	375	D1239 [Saccharomyces cerevisiae]
GI:6320008	EMBL	CAA98770.1	375	unnamed protein product [Saccharomyces cerevisiae]
GI:6320008	EMBL	CBL76230.1	375	unnamed protein product [Saccharomyces cerevisiae]
GI:6320008	GenBank	EIW11501.1	375	Nus1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6320008	SwissProt	Q12063.1	375	RecName: Full=Dehydrodolichyl diphosphate syntase complex subunit NUS1; AltName: Full=Di-trans,poly-cis-decaprenylcistransferase; AltName: Full=Nuclear undecaprenyl pyrophosphate synthase 1; AltName: Full=Undecaprenyl diphosphate synthase; Short=UDS [Saccharomyces cerevisiae S288c]
GI:6320008	Third Party Genbank	DAA11670.1	375	TPA: Nus1p [Saccharomyces cerevisiae S288c]

Reference	Database	Accession	Length	Protein Name
GI:6320008	EMBL	CAY78315.1	375	Nus1p [Saccharomyces cerevisiae EC1118]
GI:6320008	GenBank	EDN60169.1	375	nuclear undecaprenyl pyrophosphate synthase [Saccharomyces cerevisiae YJM789]
GI:6320008	GenBank	EEU05312.1	375	Nus1p [Saccharomyces cerevisiae JAY291]
GI:6320008	GenBank	EHN03359.1	375	Nus1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6320008	GenBank	EWG86898.1	375	Nus1p [Saccharomyces cerevisiae R008]
GI:6320008	gnl	McCuskerlabDuke	375	Nus1p [Saccharomyces cerevisiae YJM993]