Gene/Proteome Database (LMPD)

LMPD ID
LMP006862
Gene ID
852019
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Ste14p
Gene Symbol
STE14
Synonyms
-
Alternate Names
Ste14p
Chromosome
IV
EC Number
2.1.1.100

Proteins

Ste14p
Refseq ID NP_010698
Protein GI 6320618
UniProt ID P32584
mRNA ID NM_001180718
Length 239
RefSeq Status PROVISIONAL
MHQDFQEDEHEYPDIRRNPLHEVTMTSYILGILLGIFVGLFPQIRFKNFNLFIIALSLFHFLEYYITAKYNPLKVHSESFLLNNGKSYMAAHSFAILECLVESFLFPDLKIFSYSLATKLCTVLGCLLVILGQYTRTIAMHTAGHSFSHIVKTKKESDHVLVKTGVYSWSRHPSYLGFFWWAIGTQLLLLNPLSLVIFIFVLWKFFSDRIRVEEKYLIEFFSAEYIEYKNKVGVGIPFI

Gene Information

Entrez Gene ID
852019
Gene Name
Ste14p
Gene Symbol
STE14
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:SGD C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005637 IMP:SGD C nuclear inner membrane
GO:0004671 IDA:SGD F protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0006481 IMP:SGD P C-terminal protein methylation
GO:0007323 IMP:SGD P peptide pheromone maturation
GO:0019236 IEA:UniProtKB-KW P response to pheromone

KEGG Pathway Links

KEGG Pathway ID Description
ko00900 Terpenoid backbone biosynthesis
sce00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR007269 Isoprenylcysteine carboxyl methyltransferase
IPR025770 Protein-S-isoprenylcysteine O-methyltransferase

UniProt Annotations

Entry Information

Gene Name
Ste14p
Protein Entry
STE14_YEAST
UniProt ID
P32584
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C- terminal S-farnesyl-L-cysteine methyl ester.
Function Mediates C-terminal methylation of the isoprenylated C- terminal cysteine in A-factor mating pheromone and Ras proteins. {ECO:0000269|PubMed:8289819}.
Miscellaneous Present with 2690 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006862 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320618 RefSeq NP_010698 239 Ste14p

Identical Sequences to LMP006862 proteins

Reference Database Accession Length Protein Name
GI:6320618 GenBank AAE71089.1 239 Sequence 11 from patent US 6232108
GI:6320618 GenBank AAN26459.1 239 Sequence 11 from patent US 6432403
GI:6320618 GenBank EIW11620.1 239 Ste14p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6320618 GenBank EWH19101.1 239 Ste14p [Saccharomyces cerevisiae P283]
GI:6320618 gnl McCuskerlabDuke 239 Ste14p [Saccharomyces cerevisiae YJM993]
GI:6320618 Third Party Genbank DAA12252.1 239 TPA: Ste14p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP006862 proteins

Reference Database Accession Length Protein Name
GI:6320618 EMBL CAY78912.1 239 Ste14p [Saccharomyces cerevisiae EC1118]
GI:6320618 GenBank EDV07923.1 239 protein-S-isoprenylcysteine O-methyltransferase [Saccharomyces cerevisiae RM11-1a]
GI:6320618 GenBank EDZ72855.1 239 YDR410Cp-like protein [Saccharomyces cerevisiae AWRI1631]
GI:6320618 GenBank EEU04288.1 239 Ste14p [Saccharomyces cerevisiae JAY291]
GI:6320618 GenBank EGA75436.1 239 Ste14p [Saccharomyces cerevisiae AWRI796]
GI:6320618 GenBank EWG86747.1 239 Ste14p [Saccharomyces cerevisiae R008]