LIPID MAPS

LMPD ID

LMP006859

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

malate dehydrogenase MDH3

Gene Symbol

MDH3

Synonyms

-

Chromosome

IV

EC Number

1.1.1.37;

malate dehydrogenase MDH3
Refseq ID	NP_010205
Protein GI	6320125
UniProt ID	P32419
mRNA ID	NM_001180137
Length	343
MVKVAILGASGGVGQPLSLLLKLSPYVSELALYDIRAAEGIGKDLSHINTNSSCVGYDKDSIENTLSNAQVVLIPAGVPRKPGLTRDDLFKMNAGIVKSLVTAVGKFAPNARILVISNPVNSLVPIAVETLKKMGKFKPGNVMGVTNLDLVRAETFLVDYLMLKNPKIGQEQDKTTMHRKVTVIGGHSGETIIPIITDKSLVFQLDKQYEHFIHRVQFGGDEIVKAKQGAGSATLSMAFAGAKFAEEVLRSFHNEKPETESLSAFVYLPGLKNGKKAQQLVGDNSIEYFSLPIVLRNGSVVSIDTSVLEKLSPREEQLVNTAVKELRKNIEKGKSFILDSSKL

Entrez Gene ID

Gene Name

malate dehydrogenase MDH3

Gene Symbol

MDH3

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005782	IDA:SGD	C	peroxisomal matrix
GO:0005777	IDA:SGD	C	peroxisome
GO:0030060	IDA:SGD	F	L-malate dehydrogenase activity
GO:0003729	IDA:SGD	F	mRNA binding
GO:0006735	IMP:SGD	P	NADH regeneration
GO:0006635	IMP:SGD	P	fatty acid beta-oxidation
GO:0006097	IEA:UniProtKB-KW	P	glyoxylate cycle
GO:0006108	IEA:InterPro	P	malate metabolic process
GO:0006099	IEA:UniProtKB-KW	P	tricarboxylic acid cycle

KEGG Pathway ID	Description
sce01110	Biosynthesis of secondary metabolites
ko01200	Carbon metabolism
sce01200	Carbon metabolism
ko00020	Citrate cycle (TCA cycle)
sce00020	Citrate cycle (TCA cycle)
M00009	Citrate cycle (TCA cycle, Krebs cycle)
sce_M00009	Citrate cycle (TCA cycle, Krebs cycle)
M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
sce_M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
ko00270	Cysteine and methionine metabolism
sce00270	Cysteine and methionine metabolism
ko00630	Glyoxylate and dicarboxylate metabolism
sce00630	Glyoxylate and dicarboxylate metabolism
M00012	Glyoxylate cycle
sce_M00012	Glyoxylate cycle
sce01100	Metabolic pathways
ko00620	Pyruvate metabolism
sce00620	Pyruvate metabolism

BIOCYC Pathway ID	Description
MALATE-ASPARTATE-SHUTTLE-PWY	aspartate degradation II
GLYOXYLATE-BYPASS	glyoxylate cycle

REACTOME Pathway ID	Description
5618051	Citric acid cycle (TCA cycle)
5618026	Disease
5618020	Gluconeogenesis
5618021	Glucose metabolism
5618025	Glycogen storage diseases
5618023	Metabolism
5618022	Metabolism of carbohydrates
5618024	Myoclonic epilepsy of Lafora
5618052	Pyruvate metabolism and Citric Acid (TCA) cycle
5618053	The citric acid (TCA) cycle and respiratory electron transport

Accession	Description
IPR001557	L-lactate/malate dehydrogenase
IPR015955	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
IPR022383	Lactate/malate dehydrogenase, C-terminal
IPR001236	Lactate/malate dehydrogenase, N-terminal
IPR001252	Malate dehydrogenase, active site
IPR010097	Malate dehydrogenase, type 1
IPR016040	NAD(P)-binding domain

Gene Name

malate dehydrogenase MDH3

Protein Entry

MDHP_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	(S)-malate + NAD(+) = oxaloacetate + NADH
Catalytic Activity	(S)-malate + NAD(+) = oxaloacetate + NADH. {ECO:0000255\|PROSITE-ProRule:PRU10004}.
Miscellaneous	Present with 3300 molecules/cell in log phase SD medium
Miscellaneous	Present with 3300 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Miscellaneous	Yeast contains at least 3 malate dehydrogenase isoenzymes: a mitochondrial (MDH1), a cytoplasmic (MDH2) and a peroxisomal (MDH3).
Similarity	Belongs to the LDH/MDH superfamily. MDH type 1 family
Similarity	Belongs to the LDH/MDH superfamily. MDH type 1 family. {ECO:0000305}.
Subcellular Location	Peroxisome.
Subunit	Homodimer.