Gene/Proteome Database (LMPD)

LMPD ID
LMP006855
Gene ID
852568
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
3-dehydrosphinganine reductase
Gene Symbol
TSC10
Synonyms
-
Alternate Names
3-dehydrosphinganine reductase
Chromosome
II
EC Number
1.1.1.102

Proteins

3-dehydrosphinganine reductase
Refseq ID NP_009824
Protein GI 330443467
UniProt ID P38342
mRNA ID NM_001178613
Length 320
RefSeq Status PROVISIONAL
MKFTLEDQVVLITGGSQGLGKEFAKKYYNEAENTKIIIVSRSEARLLDTCNEIRIEAHLRRETTDEGQVQHKLAAPLDLEQRLFYYPCDLSCYESVECLFNALRDLDLLPTQTLCCAGGAVPKLFRGLSGHELNLGMDINYKTTLNVAHQIALAEQTKEHHLIIFSSATALYPFVGYSQYAPAKAAIKSLVAILRQELTNFRISCVYPGNFESEGFTVEQLTKPEITKLIEGPSDAIPCKQACDIIAKSLARGDDDVFTDFVGWMIMGMDLGLTAKKSRFVPLQWIFGVLSNILVVPFYMVGCSWYIRKWFRENDGKKAN

Gene Information

Entrez Gene ID
852568
Gene Name
3-dehydrosphinganine reductase
Gene Symbol
TSC10
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005811 IDA:SGD C lipid particle
GO:0047560 IDA:SGD F 3-dehydrosphinganine reductase activity
GO:0006666 IDA:SGD P 3-keto-sphinganine metabolic process
GO:0030148 IDA:SGD P sphingolipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
SPHINGOLIPID-SYN-PWY sphingolipid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5618508 Sphingolipid de novo biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR

UniProt Annotations

Entry Information

Gene Name
3-dehydrosphinganine reductase
Protein Entry
TSC10_YEAST
UniProt ID
P38342
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Sphinganine + NADP(+) = 3-dehydrosphinganine + NADPH.
Function Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). {ECO:0000269|PubMed:9804843}.
Miscellaneous Present with 7700 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006855 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
330443467 RefSeq NP_009824 320 3-dehydrosphinganine reductase

Identical Sequences to LMP006855 proteins

Reference Database Accession Length Protein Name
GI:330443467 GenBank EIW12206.1 320 Tsc10p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:330443467 GenBank EWG87826.1 320 Tsc10p [Saccharomyces cerevisiae R008]
GI:330443467 GenBank EWG92586.1 320 Tsc10p [Saccharomyces cerevisiae P301]
GI:330443467 GenBank EWG97452.1 320 Tsc10p [Saccharomyces cerevisiae R103]
GI:330443467 GenBank EWH19637.1 320 Tsc10p [Saccharomyces cerevisiae P283]
GI:330443467 gnl McCuskerlabDuke 320 Tsc10p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP006855 proteins

Reference Database Accession Length Protein Name
GI:330443467 DBBJ GAA21813.1 320 K7_Tsc10p [Saccharomyces cerevisiae Kyokai no. 7]
GI:330443467 EMBL CAA49930.1 320 unnamed protein product [Saccharomyces cerevisiae]
GI:330443467 EMBL CAA85228.1 320 unnamed protein product [Saccharomyces cerevisiae]
GI:330443467 GenBank EDN64874.1 320 3-ketosphinganine reductase [Saccharomyces cerevisiae YJM789]
GI:330443467 GenBank EGA79830.1 320 Tsc10p [Saccharomyces cerevisiae Vin13]
GI:330443467 GenBank EGA83865.1 320 Tsc10p [Saccharomyces cerevisiae Lalvin QA23]