LIPID MAPS

LMPD ID

LMP006822

Gene ID

855018

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Plb2p

Gene Symbol

PLB2

Synonyms

-

Chromosome

XIII

EC Number

3.1.1.5

Plb2p
Refseq ID	NP_013719
Protein GI	6323648
UniProt ID	Q03674
mRNA ID	NM_001182502
Length	706
MQLRNILQASSLISGLSLAADSSSTTGDGYAPSIIPCPSDDTSLVRNASGLSTAETDWLKKRDAYTKEALHSFLSRATSNFSDTSLLSTLFSSNSSNVPKIGIACSGGGYRAMLGGAGMIAAMDNRTDGANEHGLGGLLQSSTYLSGLSGGNWLTGTLAWNNWTSVQEIVDHMSESDSIWNITKSIVNPGGSNLTYTIERWESIVQEVQAKSDAGFNISLSDLWARALSYNFFPSLPDAGSALTWSSLRDVDVFKNGEMPLPITVADGRYPGTTVINLNATLFEFTPFEMGSWDPSLNAFTDVKYLGTNVTNGKPVNKDQCVSGYDNAGFVIATSASLFNEFSLEASTSTYYKMINSFANKYVNNLSQDDDDIAIYAANPFKDTEFVDRNYTSSIVDADDLFLVDGGEDGQNLPLVPLIKKERDLDVVFALDISDNTDESWPSGVCMTNTYERQYSKQGKGMAFPYVPDVNTFLNLGLTNKPTFFGCDAKNLTDLEYIPPLVVYIPNTKHSFNGNQSTLKMNYNVTERLGMIRNGFEAATMGNFTDDSNFLGCIGCAIIRRKQESLNATLPPECTKCFADYCWNGTLSTSANPELSGNSTYQSGAIASAISEATDGIPITALLGSSTSGNTTSNSTTSTSSNVTSNSNSSSNTTLNSNSSSSSISSSTARSSSSTANKANAAAISYANTNTLMSLLGAITALFGLI

Entrez Gene ID

855018

Gene Name

Plb2p

Gene Symbol

PLB2

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0031225	IEA:UniProtKB-KW	C	anchored component of membrane
GO:0005576	IDA:SGD	C	extracellular region
GO:0009277	IDA:SGD	C	fungal-type cell wall
GO:0004622	IDA:SGD	F	lysophospholipase activity
GO:0006650	IDA:SGD	P	glycerophospholipid metabolic process
GO:0009395	IEA:InterPro	P	phospholipid catabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
ko00564	Glycerophospholipid metabolism
sce00564	Glycerophospholipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY-7409	phospholipid remodeling (phosphatidylethanolamine)
PWY-7409	phospholipid remodeling (phosphatidylethanolamine, yeast)

InterPro Annotations

Accession	Description
IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
IPR002642	Lysophospholipase, catalytic domain

Entry Information

Gene Name

Plb2p

Protein Entry

PLB2_YEAST

UniProt ID

Q03674

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Function	Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol > phosphatidylcholine > phosphatidylethanolamine
Function	Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol > phosphatidylcholine > phosphatidylethanolamine. {ECO:0000269\|PubMed:10497163}.
Interaction	P38800:YHR080C; NbExp=1; IntAct=EBI-2079187, EBI-24597;
Miscellaneous	Present with 623 molecules/cell in log phase SD medium
Miscellaneous	Present with 623 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Ptm	The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
Similarity	Belongs to the lysophospholipase family
Similarity	Belongs to the lysophospholipase family. {ECO:0000305}.
Similarity	Contains 1 PLA2c domain. {ECO:0000255\|PROSITE- ProRule:PRU00555}.
Subcellular Location	Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).