Gene/Proteome Database (LMPD)

LMPD ID
LMP006764
Gene ID
8228
Species
Homo sapiens (Human)
Gene Name
patatin-like phospholipase domain containing 4
Gene Symbol
PNPLA4
Synonyms
DXS1283E; GS2; iPLA2eta
Alternate Names
patatin-like phospholipase domain-containing protein 4; IPLA2 eta; calcium independent phospholipases A2 eta
Chromosome
X
Map Location
Xp22.3
EC Number
3.1.1.3
Summary
This gene encodes a member of the patatin-like family of phospholipases. The encoded enzyme has both triacylglycerol lipase and transacylase activities and may be involved in adipocyte triglyceride homeostasis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome Y. [provided by RefSeq, Feb 2010]
Orthologs
View orthologs and multiple alignments for PNPLA4

Proteins

patatin-like phospholipase domain-containing protein 4 isoform 1 precursor
Refseq ID NP_001135861
Protein GI 215422355
UniProt ID P41247
mRNA ID NM_001142389
Length 253
RefSeq Status REVIEWED
MKHINLSFAACGFLGIYHLGAASALCRHGKKLVKDVKAFAGASAGSLVASVLLTAPEKIEECNQFTYKFAEEIRRQSFGAVTPGYDFMARLRSGMESILPPSAHELAQNRLHVSITNAKTRENHLVSTFSSREDLIKVLLASSFVPIYAGLKLVEYKGQKWVDGGLTNALPILPVGRTVTISPFSGRLDISPQDKGQLDLYVNIAKQDIMLSLANLVRLNQALFPPSKRKMESLYQCGFDDTVKFLLKENWFE
patatin-like phospholipase domain-containing protein 4 isoform 1 precursor
Refseq ID NP_004641
Protein GI 42415471
UniProt ID P41247
mRNA ID NM_004650
Length 253
RefSeq Status REVIEWED
Protein sequence is identical to GI:215422355 (mRNA isoform)
sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2493 peptide sequence: MKHINLSFAACGFLGIYHLGAASA sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2493 peptide sequence: MKHINLSFAACGFLGIYHLGAASA
patatin-like phospholipase domain-containing protein 4 isoform 2
Refseq ID NP_001166143
Protein GI 291045302
UniProt ID P41247
mRNA ID NM_001172672
Length 166
RefSeq Status REVIEWED
MARLRSGMESILPPSAHELAQNRLHVSITNAKTRENHLVSTFSSREDLIKVLLASSFVPIYAGLKLVEYKGQKWVDGGLTNALPILPVGRTVTISPFSGRLDISPQDKGQLDLYVNIAKQDIMLSLANLVRLNQALFPPSKRKMESLYQCGFDDTVKFLLKENWFE

Gene Information

Entrez Gene ID
8228
Gene Name
patatin-like phospholipase domain containing 4
Gene Symbol
PNPLA4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0004806 IEA:UniProtKB-EC F triglyceride lipase activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00830 Retinol metabolism
ko00830 Retinol metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
LIPAS-PWY triacylglycerol degradation

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR002641 Patatin/Phospholipase A2-related

UniProt Annotations

Entry Information

Gene Name
patatin-like phospholipase domain containing 4
Protein Entry
PLPL4_HUMAN
UniProt ID
P41247
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P41247-1; Sequence=Displayed; Name=2; IsoId=P41247-2; Sequence=VSP_043089; Note=No experimental confirmation available.;
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Function Lipid hydrolase.
Similarity Contains 1 patatin domain.
Tissue Specificity Expressed in all tissues examined, including heart, brain, placenta, lung, liver, muscle, kidney, pancreas and spleen.

Identical and Related Proteins

Unique RefSeq proteins for LMP006764 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
215422355 RefSeq NP_001135861 253 patatin-like phospholipase domain-containing protein 4 isoform 1 precursor
291045302 RefSeq NP_001166143 166 patatin-like phospholipase domain-containing protein 4 isoform 2

Identical Sequences to LMP006764 proteins

Reference Database Accession Length Protein Name
GI:215422355 DBBJ BAF82577.1 253 unnamed protein product [Homo sapiens]
GI:291045302 DBBJ BAG65374.1 166 unnamed protein product [Homo sapiens]
GI:215422355 GenBank EAW98753.1 253 patatin-like phospholipase domain containing 4, isoform CRA_b [Homo sapiens]
GI:215422355 GenBank ACM97580.1 253 Sequence 7 from patent US 7473541
GI:215422355 GenBank AEU43490.1 253 Sequence 239 from patent US 8052970
GI:215422355 GenBank AEU43519.1 253 Sequence 268 from patent US 8052970
GI:215422355 GenBank AHD78237.1 253 Sequence 25574 from patent US 8586006

Related Sequences to LMP006764 proteins

Reference Database Accession Length Protein Name
GI:291045302 GenBank AAA16491.1 253 a gene isolated from a CpG island between STS and KAL [Homo sapiens]
GI:291045302 GenBank AAA17838.1 253 unknown [Homo sapiens]
GI:291045302 GenBank EAW98752.1 253 patatin-like phospholipase domain containing 4, isoform CRA_b [Homo sapiens]
GI:291045302 GenBank AEU43490.1 253 Sequence 239 from patent US 8052970
GI:291045302 GenBank AEU43519.1 253 Sequence 268 from patent US 8052970
GI:215422355 GenBank JAA02641.1 253 patatin-like phospholipase domain containing 4 [Pan troglodytes]
GI:215422355 GenBank JAA23324.1 253 patatin-like phospholipase domain containing 4 [Pan troglodytes]
GI:215422355 RefSeq XP_001139947.1 253 PREDICTED: patatin-like phospholipase domain-containing protein 4 [Pan troglodytes]
GI:215422355 RefSeq XP_008958364.1 253 PREDICTED: patatin-like phospholipase domain-containing protein 4 [Pan paniscus]
GI:215422355 RefSeq XP_009437015.1 253 PREDICTED: patatin-like phospholipase domain-containing protein 4 [Pan troglodytes]
GI:215422355 RefSeq XP_009437016.1 253 PREDICTED: patatin-like phospholipase domain-containing protein 4 [Pan troglodytes]
GI:291045302 SwissProt P41247.3 253 RecName: Full=Patatin-like phospholipase domain-containing protein 4; AltName: Full=Protein GS2 [Homo sapiens]