Gene/Proteome Database (LMPD)

LMPD ID
LMP006747
Gene ID
64834
Species
Homo sapiens (Human)
Gene Name
ELOVL fatty acid elongase 1
Gene Symbol
ELOVL1
Synonyms
Ssc1
Alternate Names
elongation of very long chain fatty acids protein 1; ELOVL FA elongase 1; 3-keto acyl-CoA synthase ELOVL1; very-long-chain 3-oxoacyl-CoA synthase 1; elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
Chromosome
1
Map Location
1p34.2
EC Number
2.3.1.199

Proteins

elongation of very long chain fatty acids protein 1 isoform 1
Refseq ID NP_073732
Protein GI 13489093
UniProt ID Q9BW60
mRNA ID NM_022821
Length 279
RefSeq Status VALIDATED
MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN
elongation of very long chain fatty acids protein 1 isoform 1
Refseq ID NP_001243328
Protein GI 373938448
UniProt ID Q9BW60
mRNA ID NM_001256399
Length 279
RefSeq Status VALIDATED
Protein sequence is identical to GI:13489093 (mRNA isoform)
elongation of very long chain fatty acids protein 1 isoform 2
Refseq ID NP_001243330
Protein GI 373938450
UniProt ID Q9BW60
mRNA ID NM_001256401
Length 252
RefSeq Status VALIDATED
MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN
elongation of very long chain fatty acids protein 1 isoform 3
Refseq ID NP_001243331
Protein GI 373938450
UniProt ID Q9BW60
mRNA ID NM_001256402
Length 252
RefSeq Status VALIDATED
MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN

Gene Information

Entrez Gene ID
64834
Gene Name
ELOVL fatty acid elongase 1
Gene Symbol
ELOVL1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:UniProtKB C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0030176 NAS:UniProtKB C integral component of endoplasmic reticulum membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0009922 IDA:UniProtKB F fatty acid elongase activity
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0034625 IDA:UniProtKB P fatty acid elongation, monounsaturated fatty acid
GO:0019367 IDA:UniProtKB P fatty acid elongation, saturated fatty acid
GO:0035338 TAS:Reactome P long-chain fatty-acyl-CoA biosynthetic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0030148 IMP:UniProtKB P sphingolipid biosynthetic process
GO:0019432 TAS:Reactome P triglyceride biosynthetic process
GO:0042761 IDA:UniProtKB P very long-chain fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00062 Fatty acid elongation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5972 stearate biosynthesis I (animals)

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_380 Synthesis of very long-chain fatty acyl-CoAs

Domain Information

InterPro Annotations

Accession Description
IPR002076 ELO family

UniProt Annotations

Entry Information

Gene Name
ELOVL fatty acid elongase 1
Protein Entry
ELOV1_HUMAN
UniProt ID
Q9BW60
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BW60-1; Sequence=Displayed; Name=2; IsoId=Q9BW60-2; Sequence=VSP_045436;
Catalytic Activity A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Domain The di-lysine motif may confer endoplasmic reticulum localization.
Function Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids (VLCFAs). Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. {ECO
Interaction O75832:PSMD10; NbExp=1; IntAct=EBI-1050331, EBI-752185; Q6IBS0:TWF2; NbExp=1; IntAct=EBI-1050331, EBI-722204;
Sequence Caution Sequence=AAD34083.1; Type=Frameshift; Positions=189; Evidence= ;
Similarity Belongs to the ELO family.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Subunit Interacts with LASS2, TECR and HSD17B12.
Tissue Specificity Ubiquitous.

Identical and Related Proteins

Unique RefSeq proteins for LMP006747 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13489093 RefSeq NP_073732 279 elongation of very long chain fatty acids protein 1 isoform 1
373938450 RefSeq NP_001243330 252 elongation of very long chain fatty acids protein 1 isoform 2
373938450 RefSeq NP_001243331 252 elongation of very long chain fatty acids protein 1 isoform 3

Identical Sequences to LMP006747 proteins

Reference Database Accession Length Protein Name
GI:373938450 DBBJ BAG60436.1 252 unnamed protein product [Homo sapiens]
GI:373938450 DBBJ BAG60436.1 252 unnamed protein product [Homo sapiens]
GI:13489093 GenBank ABU26696.1 279 Sequence 27 from patent US 7227007
GI:13489093 GenBank ABY03474.1 279 Sequence 59 from patent US 7297523
GI:13489093 GenBank ADC00605.1 279 Sequence 27 from patent US 7629453
GI:13489093 GenBank AFO18225.1 279 Sequence 39 from patent US 8206947
GI:13489093 GenBank AIC52160.1 279 ELOVL1, partial [synthetic construct]
GI:13489093 RefSeq NP_001243328.1 279 elongation of very long chain fatty acids protein 1 isoform 1 [Homo sapiens]

Related Sequences to LMP006747 proteins

Reference Database Accession Length Protein Name
GI:373938450 GenBank AAH00618.1 279 Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 [Homo sapiens]
GI:373938450 GenBank AAH00618.1 279 Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 [Homo sapiens]
GI:13489093 GenBank EAX07100.1 314 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1, partial [Homo sapiens]
GI:13489093 GenBank ACE25814.1 314 Sequence 11066 from patent US 7368531
GI:13489093 GenBank ACH36565.1 314 Sequence 11066 from patent US 7411051
GI:13489093 GenBank AFL60217.1 280 Sequence 415 from patent US 8106165
GI:373938450 GenBank AFO18225.1 279 Sequence 39 from patent US 8206947
GI:373938450 GenBank AFO18225.1 279 Sequence 39 from patent US 8206947
GI:13489093 RefSeq XP_001173622.1 279 PREDICTED: elongation of very long chain fatty acids protein 1 isoform X1 [Pan troglodytes]
GI:13489093 RefSeq XP_001173687.1 279 PREDICTED: elongation of very long chain fatty acids protein 1 isoform X1 [Pan troglodytes]
GI:373938450 RefSeq XP_004025660.1 252 PREDICTED: elongation of very long chain fatty acids protein 1 isoform 7 [Gorilla gorilla gorilla]
GI:373938450 RefSeq XP_004025660.1 252 PREDICTED: elongation of very long chain fatty acids protein 1 isoform 7 [Gorilla gorilla gorilla]
GI:373938450 RefSeq XP_004614245.1 252 PREDICTED: elongation of very long chain fatty acids protein 1 isoform X2 [Sorex araneus]
GI:373938450 RefSeq XP_004614245.1 252 PREDICTED: elongation of very long chain fatty acids protein 1 isoform X2 [Sorex araneus]
GI:373938450 RefSeq XP_004678943.1 252 PREDICTED: elongation of very long chain fatty acids protein 1 isoform X2 [Condylura cristata]
GI:373938450 RefSeq XP_004678943.1 252 PREDICTED: elongation of very long chain fatty acids protein 1 isoform X2 [Condylura cristata]
GI:373938450 RefSeq XP_005543735.1 252 PREDICTED: elongation of very long chain fatty acids protein 1 isoform X4 [Macaca fascicularis]
GI:373938450 RefSeq XP_005543735.1 252 PREDICTED: elongation of very long chain fatty acids protein 1 isoform X4 [Macaca fascicularis]