Gene/Proteome Database (LMPD)

LMPD ID
LMP006717
Gene ID
79135
Species
Homo sapiens (Human)
Gene Name
apolipoprotein O
Gene Symbol
APOO
Synonyms
FAM121B
Alternate Names
apolipoprotein O; brain my025; family with sequence similarity 121B
Chromosome
X
Map Location
Xp22.11
Summary
This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]
Orthologs
View orthologs and multiple alignments for APOO

Proteins

apolipoprotein O precursor
Refseq ID NP_077027
Protein GI 13129148
UniProt ID Q9BUR5
mRNA ID NM_024122
Length 198
RefSeq Status REVIEWED
MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAPPGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK
sig_peptide: 1..23 calculated_mol_wt: 2556 peptide sequence: MFKVIQRSVGPASLSLLTFKVYA mat_peptide: 24..198 product: apolipoprotein O calculated_mol_wt: 19747 peptide sequence: APKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAPPGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK

Gene Information

Entrez Gene ID
79135
Gene Name
apolipoprotein O
Gene Symbol
APOO
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 ISS:BHF-UCL C extracellular space
GO:0034364 IEA:UniProtKB-KW C high-density lipoprotein particle
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0034362 IEA:UniProtKB-KW C low-density lipoprotein particle
GO:0005739 IDA:UniProt C mitochondrion
GO:0034361 IEA:UniProtKB-KW C very-low-density lipoprotein particle
GO:0006869 IEA:UniProtKB-KW P lipid transport

Domain Information

InterPro Annotations

Accession Description
IPR019166 Apolipoprotein O

UniProt Annotations

Entry Information

Gene Name
apolipoprotein O
Protein Entry
APOO_HUMAN
UniProt ID
Q9BUR5
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BUR5-1; Sequence=Displayed; Name=2; IsoId=Q9BUR5-2; Sequence=VSP_023333;
Function Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.
Ptm O-glycosylation; glycosaminoglycan of chondroitin-sulfate type.
Similarity Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
Subcellular Location Membrane ; Single-pass membrane protein {ECO
Tissue Specificity Expressed in all tissues examined. Up- regulated in diabetic heart.

Identical and Related Proteins

Unique RefSeq proteins for LMP006717 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13129148 RefSeq NP_077027 198 apolipoprotein O precursor

Identical Sequences to LMP006717 proteins

Reference Database Accession Length Protein Name
GI:13129148 GenBank AFL59835.1 198 Sequence 550 from patent US 8106156
GI:13129148 RefSeq XP_003261199.1 198 PREDICTED: apolipoprotein O isoform 1 [Nomascus leucogenys]
GI:13129148 RefSeq XP_006724579.1 198 PREDICTED: apolipoprotein O isoform X1 [Homo sapiens]
GI:13129148 RefSeq XP_006724580.1 198 PREDICTED: apolipoprotein O isoform X2 [Homo sapiens]
GI:13129148 RefSeq XP_009232937.1 198 PREDICTED: apolipoprotein O isoform X1 [Pongo abelii]
GI:13129148 RefSeq XP_009232938.1 198 PREDICTED: apolipoprotein O isoform X1 [Pongo abelii]

Related Sequences to LMP006717 proteins

Reference Database Accession Length Protein Name
GI:13129148 GenBank AFE66011.1 198 apolipoprotein O precursor [Macaca mulatta]
GI:13129148 GenBank AFH28786.1 198 apolipoprotein O precursor [Macaca mulatta]
GI:13129148 GenBank AFI33634.1 198 apolipoprotein O precursor [Macaca mulatta]
GI:13129148 RefSeq NP_001244561.1 198 apolipoprotein O [Macaca mulatta]
GI:13129148 RefSeq XP_003917556.1 198 PREDICTED: apolipoprotein O isoform X1 [Papio anubis]
GI:13129148 RefSeq XP_005593236.1 198 PREDICTED: apolipoprotein O isoform X2 [Macaca fascicularis]