Gene/Proteome Database (LMPD)

LMPD ID
LMP006710
Gene ID
340654
Species
Homo sapiens (Human)
Gene Name
lipase, family member M
Gene Symbol
LIPM
Synonyms
LIPL3; bA304I5.1
Alternate Names
lipase member M; lipase M; lipase-like, ab-hydrolase domain containing 3; lipase-like abhydrolase domain-containing protein 3
Chromosome
10
Map Location
10q23.31
EC Number
3.1.1.-

Proteins

lipase member M precursor
Refseq ID NP_001121687
Protein GI 189571695
UniProt ID Q5VYY2
mRNA ID NM_001128215
Length 423
RefSeq Status VALIDATED
MLETLSRQWIVSHRMEMWLLILVAYMFQRNVNSVHMPTKAVDPEAFMNISEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTGSRPVVLLQHGLVGGASNWISNLPNNSLGFILADAGFDVWMGNSRGNAWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQEKIYYVGYSQGTTMGFIAFSTMPELAQKIKMYFALAPIATVKHAKSPGTKFLLLPDMMIKGLFGKKEFLYQTRFLRQLVIYLCGQVILDQICSNIMLLLGGFNTNNMNMSRASVYAAHTLAGTSVQNILHWSQAVNSGELRAFDWGSETKNLEKCNQPTPVRYRVRDMTVPTAMWTGGQDWLSNPEDVKMLLSEVTNLIYHKNIPEWAHVDFIWGLDAPHRMYNEIIHLMQQEETNLSQGRCEAVL
sig_peptide: 1..33 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q5VYY2.2) calculated_mol_wt: 4097 peptide sequence: MLETLSRQWIVSHRMEMWLLILVAYMFQRNVNS mat_peptide: 34..423 product: Lipase member M experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q5VYY2.2) calculated_mol_wt: 44154 peptide sequence: VHMPTKAVDPEAFMNISEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTGSRPVVLLQHGLVGGASNWISNLPNNSLGFILADAGFDVWMGNSRGNAWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQEKIYYVGYSQGTTMGFIAFSTMPELAQKIKMYFALAPIATVKHAKSPGTKFLLLPDMMIKGLFGKKEFLYQTRFLRQLVIYLCGQVILDQICSNIMLLLGGFNTNNMNMSRASVYAAHTLAGTSVQNILHWSQAVNSGELRAFDWGSETKNLEKCNQPTPVRYRVRDMTVPTAMWTGGQDWLSNPEDVKMLLSEVTNLIYHKNIPEWAHVDFIWGLDAPHRMYNEIIHLMQQEETNLSQGRCEAVL

Gene Information

Entrez Gene ID
340654
Gene Name
lipase, family member M
Gene Symbol
LIPM
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0016788 IEA:InterPro F hydrolase activity, acting on ester bonds
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR000073 Alpha/beta hydrolase fold-1
IPR025483 Lipase, eukaryotic
IPR006693 Partial AB-hydrolase lipase domain

UniProt Annotations

Entry Information

Gene Name
lipase, family member M
Protein Entry
LIPM_HUMAN
UniProt ID
Q5VYY2
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5VYY2-1; Sequence=Displayed; Name=2; IsoId=Q5VYY2-2; Sequence=VSP_056261; Note=No experimental confirmation available.;
Function Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.
Similarity Belongs to the AB hydrolase superfamily. Lipase family.
Subcellular Location Secreted .
Tissue Specificity Exclusively expressed in the epidermis within the granular keratinocytes.

Identical and Related Proteins

Unique RefSeq proteins for LMP006710 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
189571695 RefSeq NP_001121687 423 lipase member M precursor

Identical Sequences to LMP006710 proteins

Reference Database Accession Length Protein Name
GI:189571695 GenBank AAV24417.1 423 Sequence 47 from patent US 6764677
GI:189571695 GenBank ABH70812.1 423 Sequence 47 from patent US 7033780
GI:189571695 GenBank ABR08389.1 423 lipase M [Homo sapiens]
GI:189571695 GenBank ACW02547.1 423 Sequence 417 from patent US 7547766
GI:189571695 GenBank AEN51635.1 423 Sequence 417 from patent US 8003334
GI:189571695 SwissProt Q5VYY2.2 423 RecName: Full=Lipase member M; AltName: Full=Lipase-like abhydrolase domain-containing protein 3; Flags: Precursor [Homo sapiens]

Related Sequences to LMP006710 proteins

Reference Database Accession Length Protein Name
GI:189571695 GenBank EAW50160.1 430 hCG1640331 [Homo sapiens]
GI:189571695 RefSeq XP_003255229.1 423 PREDICTED: lipase member M [Nomascus leucogenys]
GI:189571695 RefSeq XP_003312780.1 423 PREDICTED: lipase member M isoform X1 [Pan troglodytes]
GI:189571695 RefSeq XP_003810558.1 423 PREDICTED: lipase member M isoform X1 [Pan paniscus]
GI:189571695 RefSeq XP_004049794.1 423 PREDICTED: lipase member M isoform 1 [Gorilla gorilla gorilla]
GI:189571695 RefSeq XP_005565951.1 423 PREDICTED: lipase member M [Macaca fascicularis]