Gene/Proteome Database (LMPD)

LMPD ID
LMP006642
Gene ID
9489
Species
Homo sapiens (Human)
Gene Name
phosphatidylglycerophosphate synthase 1
Gene Symbol
PGS1
Synonyms
-
Alternate Names
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial; PGP synthase 1
Chromosome
17
Map Location
17q25.3
EC Number
2.7.8.5

Proteins

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial precursor
Refseq ID NP_077733
Protein GI 84508631
UniProt ID Q32NB8
mRNA ID NM_024419
Length 556
RefSeq Status VALIDATED
MAVAAAAAAGPVFWRRLLGLLPGRPGLAALLGRLSDRLGRNRDRQRRRSPWLLLAPLLSPAVPQVTSPPCCLCPEGVHRFQWIRNLVPEFGVSSSHVRVLSSPAEFFELMKGQIRVAKRRVVMASLYLGTGPLEQELVDCLESTLEKSLQAKFPSNLKVSILLDFTRGSRGRKNSRTMLLPLLRRFPEQVRVSLFHTPHLRGLLRLLIPERFNETIGLQHIKVYLFDNSVILSGANLSDSYFTNRQDRYVFLQDCAEIADFFTELVDAVGDVSLQLQGDDTVQVVDGMVHPYKGDRAEYCKAANKRVMDVINSARTRQQMLHAQTFHSNSLLTQEDAAAAGDRRPAPDTWIYPLIQMKPFEIQIDEIVTETLLTEAERGAKVYLTTGYFNLTQAYMDLVLGTRAEYQILLASPEVNGFFGAKGVAGAIPAAYVHIERQFFSEVCSLGQQERVQLQEYWRRGWTFHAKGLWLYLAGSSLPCLTLIGSPNFGYRSVHRDLEAQIAIVTENQALQQQLHQEQEQLYLRSGVVSSATFEQPSRQVKLWVKMVTPLIKNFF
transit_peptide: 1..28 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q32NB8.1) calculated_mol_wt: 2803 peptide sequence: MAVAAAAAAGPVFWRRLLGLLPGRPGLA mat_peptide: 29..556 product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q32NB8.1) calculated_mol_wt: 59945 peptide sequence: ALLGRLSDRLGRNRDRQRRRSPWLLLAPLLSPAVPQVTSPPCCLCPEGVHRFQWIRNLVPEFGVSSSHVRVLSSPAEFFELMKGQIRVAKRRVVMASLYLGTGPLEQELVDCLESTLEKSLQAKFPSNLKVSILLDFTRGSRGRKNSRTMLLPLLRRFPEQVRVSLFHTPHLRGLLRLLIPERFNETIGLQHIKVYLFDNSVILSGANLSDSYFTNRQDRYVFLQDCAEIADFFTELVDAVGDVSLQLQGDDTVQVVDGMVHPYKGDRAEYCKAANKRVMDVINSARTRQQMLHAQTFHSNSLLTQEDAAAAGDRRPAPDTWIYPLIQMKPFEIQIDEIVTETLLTEAERGAKVYLTTGYFNLTQAYMDLVLGTRAEYQILLASPEVNGFFGAKGVAGAIPAAYVHIERQFFSEVCSLGQQERVQLQEYWRRGWTFHAKGLWLYLAGSSLPCLTLIGSPNFGYRSVHRDLEAQIAIVTENQALQQQLHQEQEQLYLRSGVVSSATFEQPSRQVKLWVKMVTPLIKNFF

Gene Information

Entrez Gene ID
9489
Gene Name
phosphatidylglycerophosphate synthase 1
Gene Symbol
PGS1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:LIFEdb C endoplasmic reticulum
GO:0005743 TAS:BHF-UCL C mitochondrial inner membrane
GO:0005739 ISS:BHF-UCL C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0008444 ISS:BHF-UCL F CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
GO:0005509 ISS:BHF-UCL F calcium ion binding
GO:0032049 ISS:BHF-UCL P cardiolipin biosynthetic process
GO:0046339 ISS:BHF-UCL P diacylglycerol metabolic process
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0006655 ISS:BHF-UCL P phosphatidylglycerol biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00564 Glycerophospholipid metabolism
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121401 Glycerophospholipid biosynthesis
REACT_121280 Synthesis of PG

Domain Information

InterPro Annotations

Accession Description
IPR016270 Phospholipase D, phosphatidylserine synthase type
IPR025202 Phospholipase D-like domain
IPR001736 Phospholipase D/Transphosphatidylase

UniProt Annotations

Entry Information

Gene Name
phosphatidylglycerophosphate synthase 1
Protein Entry
PGPS1_HUMAN
UniProt ID
Q32NB8
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q32NB8-1; Sequence=Displayed; Name=2; IsoId=Q32NB8-2; Sequence=VSP_033899, VSP_033902, VSP_033903; Name=3; IsoId=Q32NB8-3; Sequence=VSP_033900, VSP_033901; Note=No experimental confirmation available.; Name=4; IsoId=Q32NB8-4; Sequence=VSP_033897, VSP_033898; Note=No experimental confirmation available.;
Catalytic Activity CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Enzyme Regulation Activated by calcium and magnesium and inhibited by other bivalent cations.
Function Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Pathway Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Sequence Caution Sequence=AAH08903.2; Type=Erroneous initiation; Evidence= ; Sequence=AAH15570.2; Type=Erroneous initiation; Evidence= ; Sequence=AAH35662.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=AAH35662.1; Type=Frameshift; Positions=420; Evidence= ; Sequence=BAB14921.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence= ;
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
Similarity Contains 2 PLD phosphodiesterase domains.
Subcellular Location Mitochondrion .

Identical and Related Proteins

Unique RefSeq proteins for LMP006642 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
84508631 RefSeq NP_077733 556 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial precursor

Identical Sequences to LMP006642 proteins

Reference Database Accession Length Protein Name
GI:84508631 DBBJ BAH14518.1 556 unnamed protein product [Homo sapiens]
GI:84508631 GenBank EAW89524.1 556 hCG1642326, isoform CRA_b [Homo sapiens]
GI:84508631 GenBank EAW89525.1 556 hCG1642326, isoform CRA_b [Homo sapiens]
GI:84508631 GenBank ACN03470.1 556 Sequence 2 from patent US 7482147
GI:84508631 GenBank ADS25848.1 556 Sequence 2 from patent US 7776577
GI:84508631 SwissProt Q32NB8.1 556 RecName: Full=CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial; AltName: Full=Phosphatidylglycerophosphate synthase 1; Short=PGP synthase 1; Flags: Precursor [Homo sapiens]

Related Sequences to LMP006642 proteins

Reference Database Accession Length Protein Name
GI:84508631 GenBank EHH58388.1 556 hypothetical protein EGM_08226 [Macaca fascicularis]
GI:84508631 GenBank JAA00978.1 556 phosphatidylglycerophosphate synthase 1 [Pan troglodytes]
GI:84508631 GenBank JAA21541.1 556 phosphatidylglycerophosphate synthase 1 [Pan troglodytes]
GI:84508631 GenBank JAA24655.1 556 phosphatidylglycerophosphate synthase 1 [Pan troglodytes]
GI:84508631 RefSeq NP_001270688.1 556 uncharacterized protein LOC101866331 [Macaca fascicularis]
GI:84508631 RefSeq XP_009431513.1 556 PREDICTED: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [Pan troglodytes]