Gene/Proteome Database (LMPD)

LMPD ID
LMP006628
Gene ID
150379
Species
Homo sapiens (Human)
Gene Name
patatin-like phospholipase domain containing 5
Gene Symbol
PNPLA5
Synonyms
GS2L; dJ388M5; dJ388M5.4
Alternate Names
patatin-like phospholipase domain-containing protein 5; GS2-like protein
Chromosome
22
Map Location
22q13.31
EC Number
3.1.1.-
Summary
This gene is a member of the patatin-like phospholipase family; its encoded protein has been shown to inhibit transacylation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
Orthologs
View orthologs and multiple alignments for PNPLA5

Proteins

patatin-like phospholipase domain-containing protein 5 isoform 1
Refseq ID NP_620169
Protein GI 20304127
UniProt ID Q7Z6Z6
mRNA ID NM_138814
Length 429
RefSeq Status REVIEWED
MGFLEEEGRWNLSFSGAGYLGAHHVGATECLRQRAPRLLQGARRIYGSSSGALNAVSIVCGKSVDFCCSHLLGMVGQLERLSLSILHPAYAPIEHVKQQLQDALPPDAHVLASQRLGISLTRWPDGRNFLVTDFATCDELIQALVCTLYFPFYCGLIPPEFRGERYIDGALSNNLPFADCPSTITVSPFHGTVDICPQSTSPNLHELNVFNFSFQISTENFFLGLICLIPPSLEVVADNCRQGYLDALRFLERRGLTKEPVLWTLVSKEPPAPADGNWDAGCDQRWKGGLSLNWKVPHVQVKDVPNFEQLSPELEAALKKACTRDPSRWARFWHSGPGQVLTYLLLPCTLPFEYIYFRSRRLVVWLPDVPADLWWMQGLLRNMALEVFSRTKAQLLGPISPPATRVLETSPLQPQIAPHREELGPTHQA
patatin-like phospholipase domain-containing protein 5 isoform 2
Refseq ID NP_001171146
Protein GI 295148044
UniProt ID Q7Z6Z6
mRNA ID NM_001177675
Length 315
RefSeq Status REVIEWED
MGFLEEEGRWNLSFSGAGYLGAHHVGATECLRQRAPRLLQGARRIYGSSSGALNAVSIVCGKSVDCPSTITVSPFHGTVDICPQSTSPNLHELNVFNFSFQISTENFFLGLICLIPPSLEVVADNCRQGYLDALRFLERRGLTKEPVLWTLVSKEPPAPADGNWDAGCDQRWKGGLSLNWKVPHVQVKDVPNFEQLSPELEAALKKACTRDPSRWARFWHSGPGQVLTYLLLPCTLPFEYIYFRSRRLVVWLPDVPADLWWMQGLLRNMALEVFSRTKAQLLGPISPPATRVLETSPLQPQIAPHREELGPTHQA

Gene Information

Entrez Gene ID
150379
Gene Name
patatin-like phospholipase domain containing 5
Gene Symbol
PNPLA5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR002641 Patatin/Phospholipase A2-related

UniProt Annotations

Entry Information

Gene Name
patatin-like phospholipase domain containing 5
Protein Entry
PLPL5_HUMAN
UniProt ID
Q7Z6Z6
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z6Z6-1; Sequence=Displayed; Name=2; IsoId=Q7Z6Z6-2; Sequence=VSP_026373;
Developmental Stage No differential expression during adipocyte differentiation.
Function Lipid hydrolase.
Similarity Contains 1 patatin domain.
Tissue Specificity Expressed in brain and pituitary gland.

Identical and Related Proteins

Unique RefSeq proteins for LMP006628 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20304127 RefSeq NP_620169 429 patatin-like phospholipase domain-containing protein 5 isoform 1
295148044 RefSeq NP_001171146 315 patatin-like phospholipase domain-containing protein 5 isoform 2

Identical Sequences to LMP006628 proteins

Reference Database Accession Length Protein Name
GI:20304127 GenBank AAI04840.1 429 Patatin-like phospholipase domain containing 5 [Homo sapiens]
GI:20304127 GenBank AAI04844.1 429 Patatin-like phospholipase domain containing 5 [Homo sapiens]
GI:20304127 GenBank AAH31820.1 429 Patatin-like phospholipase domain containing 5 [Homo sapiens]
GI:295148044 GenBank EAW73321.1 315 patatin-like phospholipase domain containing 5, isoform CRA_a [Homo sapiens]
GI:20304127 GenBank EAW73322.1 429 patatin-like phospholipase domain containing 5, isoform CRA_b [Homo sapiens]
GI:20304127 GenBank AIC53227.1 429 PNPLA5, partial [synthetic construct]
GI:20304127 SwissProt Q7Z6Z6.1 429 RecName: Full=Patatin-like phospholipase domain-containing protein 5; AltName: Full=GS2-like protein [Homo sapiens]

Related Sequences to LMP006628 proteins

Reference Database Accession Length Protein Name
GI:295148044 DBBJ BAC86866.1 315 unnamed protein product [Homo sapiens]
GI:20304127 DBBJ BAG51773.1 429 unnamed protein product [Homo sapiens]
GI:295148044 RefSeq NP_620169.1 429 patatin-like phospholipase domain-containing protein 5 isoform 1 [Homo sapiens]
GI:20304127 RefSeq XP_002831285.1 429 PREDICTED: patatin-like phospholipase domain-containing protein 5 isoform X1 [Pongo abelii]
GI:20304127 RefSeq XP_003281454.1 429 PREDICTED: patatin-like phospholipase domain-containing protein 5 isoform 1 [Nomascus leucogenys]
GI:295148044 RefSeq XP_003281455.1 321 PREDICTED: patatin-like phospholipase domain-containing protein 5 isoform 2 [Nomascus leucogenys]
GI:20304127 RefSeq XP_525619.3 429 PREDICTED: patatin-like phospholipase domain-containing protein 5 [Pan troglodytes]
GI:20304127 RefSeq XP_003812457.1 429 PREDICTED: patatin-like phospholipase domain-containing protein 5 isoform X1 [Pan paniscus]
GI:20304127 RefSeq XP_004063661.1 429 PREDICTED: patatin-like phospholipase domain-containing protein 5 isoform 1 [Gorilla gorilla gorilla]
GI:295148044 RefSeq XP_004063662.1 323 PREDICTED: patatin-like phospholipase domain-containing protein 5 isoform 2 [Gorilla gorilla gorilla]
GI:295148044 RefSeq XP_005567113.1 323 PREDICTED: patatin-like phospholipase domain-containing protein 5 isoform X4 [Macaca fascicularis]
GI:295148044 RefSeq XP_009232734.1 323 PREDICTED: patatin-like phospholipase domain-containing protein 5 isoform X2 [Pongo abelii]