Gene/Proteome Database (LMPD)

LMPD ID
LMP006624
Gene ID
284004
Species
Homo sapiens (Human)
Gene Name
hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Gene Symbol
HEXDC
Synonyms
-
Alternate Names
hexosaminidase D; beta-hexosaminidase D; beta-N-acetylhexosaminidase; N-acetyl-beta-galactosaminidase; hexosaminidase domain-containing protein
Chromosome
17
Map Location
17q25.3
EC Number
3.2.1.52

Proteins

hexosaminidase D
Refseq ID NP_775891
Protein GI 150456449
UniProt ID Q8WVB3
mRNA ID NM_173620
Length 585
RefSeq Status VALIDATED
MSGSTPFQMRLVHLDLKGAPPKVSYLSEIFPLFRALGANGLLIEYEDMFPYEGPLRLLRAKYAYSPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAHLREVGSFPCTLNPHEAESLALVGAMIDQVLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTPLVWDDMLRDLPEDQLAASGVPQLVEPVLWDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGSGPTDSLQGIILTGWQRYDHYSVLCELLPAGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPVRQAPCSPPCPLLPLPFPRPWRQLFSAGLSAGRGPAPSLAATSLPLSHKSASICAALWMRCWRATGMSLAGSAPTTASGSSSTRSWFSTSSPQRSASWHSGAPSCRSWRLPCSWLSTRMPWRSGWRKTCTPACSGCKLCCRTSARCLPPRCHPPALAGTLLRTPEGRAHARGLLLEAGGALHCQMAWAIRAHVGVVPSGPAVSCPHSVPEGPGQPLGERLENTEGSSTGRPAL

Gene Information

Entrez Gene ID
284004
Gene Name
hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Gene Symbol
HEXDC
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004563 IEA:UniProtKB-EC F beta-N-acetylhexosaminidase activity
GO:0005975 IEA:InterPro P carbohydrate metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00511 Other glycan degradation
ko00511 Other glycan degradation

Domain Information

InterPro Annotations

Accession Description
IPR015883 Glycoside hydrolase family 20, catalytic core
IPR017853 Glycoside hydrolase superfamily
IPR013781 Glycoside hydrolase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Protein Entry
HEXDC_HUMAN
UniProt ID
Q8WVB3
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WVB3-1; Sequence=Displayed; Name=2; IsoId=Q8WVB3-2; Sequence=VSP_030777; Note=No experimental confirmation available.;
Catalytic Activity Hydrolysis of terminal non-reducing N-acetyl- D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
Enzyme Regulation Inhibited by O-(2-acetamido-2-deoxy-D- glucopyranosylidene)amino N-phenylcarbamate (PUGNAc).
Function Has hexosaminidase activity.
Sequence Caution Sequence=AAH18205.2; Type=Erroneous initiation; Evidence= ; Sequence=AAH35561.1; Type=Erroneous initiation; Evidence= ; Sequence=BAB85072.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the glycosyl hydrolase 20 family.
Subcellular Location Cytoplasm. Nucleus .
Subunit Homodimer; disulfide-linked.

Identical and Related Proteins

Unique RefSeq proteins for LMP006624 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
150456449 RefSeq NP_775891 585 hexosaminidase D

Identical Sequences to LMP006624 proteins

Reference Database Accession Length Protein Name
GI:150456449 GenBank EAW89775.1 585 hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing, isoform CRA_e [Homo sapiens]

Related Sequences to LMP006624 proteins

Reference Database Accession Length Protein Name
GI:150456449 RefSeq XP_005596110.1 592 PREDICTED: LOW QUALITY PROTEIN: hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing [Macaca fascicularis]
GI:150456449 RefSeq XP_006722343.1 538 PREDICTED: hexosaminidase D isoform X5 [Homo sapiens]
GI:150456449 RefSeq XP_008959361.1 561 PREDICTED: hexosaminidase D isoform X1 [Pan paniscus]
GI:150456449 RefSeq XP_008959362.1 561 PREDICTED: hexosaminidase D isoform X1 [Pan paniscus]
GI:150456449 RefSeq XP_009250477.1 597 PREDICTED: LOW QUALITY PROTEIN: hexosaminidase D [Pongo abelii]
GI:150456449 RefSeq XP_009431838.1 561 PREDICTED: hexosaminidase D isoform X1 [Pan troglodytes]