Gene/Proteome Database (LMPD)
LMPD ID
LMP006595
Gene ID
Species
Mus musculus (Mouse)
Gene Name
patatin-like phospholipase domain containing 6
Gene Symbol
Synonyms
AI661849; MSws; Nte
Alternate Names
neuropathy target esterase; Swiss cheese; Swiss-cheese; patatin-like phospholipase domain-containing protein 6
Chromosome
8
Map Location
8 A1.1|8 1.92 cM
EC Number
3.1.1.5
Proteins
| neuropathy target esterase isoform 1 | |
|---|---|
| Refseq ID | NP_001116290 |
| Protein GI | 390608665 |
| UniProt ID | Q3TRM4 |
| mRNA ID | NM_001122818 |
| Length | 1345 |
| RefSeq Status | VALIDATED |
| MEESLQPKDCRLQDLLPSPKQSMEAPLQTGMVLGVMIGAGVAVLVTAVLILLVVRRLRVQKTPAPEGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSTTSRPRMKKKLKMLNIAKKILRIQKETPTLQRKEPPPSVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRVVSTSGTEDTSKETSGRPLDSIGAPLPGPAGDPVKPTSLEAPPAPLLSRCISMPVDISGLQGGPRSDFDMAYERGRISVSLQEEASGGPQTASPRELREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKRELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEEVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSHFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPGSGLSVPQHSELTNPASNLSTVAILPVCAEVPMMAFTLELQHALQAIGPTLLLNSDVIRALLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDTSLTPWTVRCLRQADCILIVGLGDQEPTVGQLEQMLENTAVRALKQLVLLHREEGPGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPSIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWTRGEVIEKMLTDRRSTDLNESRRADILAFPSSGFTDLAEIVSRIEPPTSYVSDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEVEEEKSTLRQRRFLPQETPSSVADA | |
| neuropathy target esterase isoform 2 | |
|---|---|
| Refseq ID | NP_056616 |
| Protein GI | 170763470 |
| UniProt ID | Q3TRM4 |
| mRNA ID | NM_015801 |
| Length | 1327 |
| RefSeq Status | VALIDATED |
| MEAPLQTGMVLGVMIGAGVAVLVTAVLILLVVRRLRVQKTPAPEGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSTTSRPRMKKKLKMLNIAKKILRIQKETPTLQRKEPPPSVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRVVSTSGTEDTSKETSGRPLDSIGAPLPGPAGDPVKPTSLEAPPAPLLSRCISMPVDISGLQGGPRSDFDMAYERGRISVSLQEEASGGPQTASPRTPTQELREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKRELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEEVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSHFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPGSGLSVPQHSELTNPASNLSTVAILPVCAEVPMMAFTLELQHALQAIGPTLLLNSDVIRALLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDTSLTPWTVRCLRQADCILIVGLGDQEPTVGQLEQMLENTAVRALKQLVLLHREEGPGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPSIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWTRGEVIEKMLTDRRSTDLNESRRADILAFPSSGFTDLAEIVSRIEPPTSYVSDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEVEEEKSTLRQRRFLPQETPSSVADA | |
Gene Information
Entrez Gene ID
Gene Name
patatin-like phospholipase domain containing 6
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0052689 | ISS:MGI | F | carboxylic ester hydrolase activity |
| GO:0004622 | IEA:UniProtKB-EC | F | lysophospholipase activity |
| GO:0001525 | IMP:MGI | P | angiogenesis |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0009887 | IMP:MGI | P | organ morphogenesis |
| GO:0046470 | IEA:InterPro | P | phosphatidylcholine metabolic process |
KEGG Pathway Links
Domain Information
InterPro Annotations
UniProt Annotations
Entry Information
Gene Name
patatin-like phospholipase domain containing 6
Protein Entry
PLPL6_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3TRM4-1; Sequence=Displayed; Name=2; IsoId=Q3TRM4-2; Sequence=VSP_026390; Note=No experimental confirmation available.; Name=3; IsoId=Q3TRM4-3; Sequence=VSP_026390, VSP_026391; Note=No experimental confirmation available.; Name=4; IsoId=Q3TRM4-4; Sequence=VSP_026392, VSP_026393; Note=No experimental confirmation available.; |
| Catalytic Activity | 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. |
| Developmental Stage | Expressed in the embryonic respiratory system, different epithelial structures and strongly in the spinal ganglia, during the development. {ECO:0000269|PubMed:10640712}. |
| Enzyme Regulation | Inhibited by a series a OPs such as mipafox (MPX), phenyl saligenin phosphate (PSP), phenyl dipentyl phosphinate (PDPP), diisopropyl fluorophosphate and paraoxon. {ECO:0000269|PubMed:16963094}. |
| Function | Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. {ECO:0000269|PubMed:12640454, ECO:0000269|PubMed:16963094}. |
| Ptm | Glycosylated. {ECO:0000250}. |
| Similarity | Belongs to the NTE family. {ECO:0000305}. |
| Similarity | Contains 1 patatin domain. {ECO:0000305}. |
| Similarity | Contains 3 cyclic nucleotide-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00060}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:16963094}; Single-pass type I membrane protein {ECO:0000269|PubMed:16963094}; Cytoplasmic side {ECO:0000269|PubMed:16963094}. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment. |
| Tissue Specificity | Expressed ubiquitously in brain of young mice. Reaching adulthood, there is a most prominent expression in Purkinje cells, granule cells and pyramidal neurons of the hippocampus and some large neurons in the medulla oblongata, nucleus dentatus and pons. {ECO:0000269|PubMed:10640712}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006595 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 390608665 | RefSeq | NP_001116290 | 1345 | neuropathy target esterase isoform 1 |
| 170763470 | RefSeq | NP_056616 | 1327 | neuropathy target esterase isoform 2 |
Identical Sequences to LMP006595 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:390608665 | RefSeq | XP_006508894.1 | 1345 | PREDICTED: neuropathy target esterase isoform X10 [Mus musculus] |
Related Sequences to LMP006595 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:170763470 | GenBank | EDL21913.1 | 1349 | patatin-like phospholipase domain containing 6, isoform CRA_a [Mus musculus] |
| GI:390608665 | GenBank | EDL21913.1 | 1349 | patatin-like phospholipase domain containing 6, isoform CRA_a [Mus musculus] |
| GI:170763470 | GenBank | EDL21915.1 | 1343 | patatin-like phospholipase domain containing 6, isoform CRA_c, partial [Mus musculus] |
| GI:390608665 | GenBank | EDL21917.1 | 1353 | patatin-like phospholipase domain containing 6, isoform CRA_e, partial [Mus musculus] |
| GI:170763470 | RefSeq | XP_006508889.1 | 1349 | PREDICTED: neuropathy target esterase isoform X5 [Mus musculus] |
| GI:390608665 | RefSeq | XP_006508889.1 | 1349 | PREDICTED: neuropathy target esterase isoform X5 [Mus musculus] |
| GI:170763470 | RefSeq | XP_006508890.1 | 1349 | PREDICTED: neuropathy target esterase isoform X6 [Mus musculus] |
| GI:390608665 | RefSeq | XP_006508890.1 | 1349 | PREDICTED: neuropathy target esterase isoform X6 [Mus musculus] |
| GI:170763470 | RefSeq | XP_006508891.1 | 1349 | PREDICTED: neuropathy target esterase isoform X7 [Mus musculus] |
| GI:390608665 | RefSeq | XP_006508891.1 | 1349 | PREDICTED: neuropathy target esterase isoform X7 [Mus musculus] |
| GI:170763470 | RefSeq | XP_006508892.1 | 1349 | PREDICTED: neuropathy target esterase isoform X8 [Mus musculus] |
| GI:390608665 | RefSeq | XP_006508892.1 | 1349 | PREDICTED: neuropathy target esterase isoform X8 [Mus musculus] |