Gene/Proteome Database (LMPD)

LMPD ID
LMP006583
Gene ID
67073
Species
Mus musculus (Mouse)
Gene Name
phosphatidylinositol 4-kinase type 2 beta
Gene Symbol
Pi4k2b
Synonyms
2610042N09Rik; 4933409G22Rik
Alternate Names
phosphatidylinositol 4-kinase type 2-beta; phosphatidylinositol 4-kinase type II-beta
Chromosome
5
Map Location
5 C1|5
EC Number
2.7.1.67

Proteins

phosphatidylinositol 4-kinase type 2-beta isoform 1
Refseq ID NP_080227
Protein GI 145966899
UniProt ID Q8CBQ5
mRNA ID NM_025951
Length 469
RefSeq Status VALIDATED
MAEACEPTRPSEDEDEEREPLLPRVAWAQPRRVAPGSAVRMQADEGADVLREPATDEPPAVSGEGSISASLSTELDRTRTTSSETNTFLEDPEFADIVLKAEQAIEIGVFPERISQGSSGSYFVKDSKRNIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLLPNQGYLSEAGAYLVDVKLNLGIVPKTKVVWLVSETFNYSAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPKVGSFQLFVKDYKEAEYWLRRFEAEPLPENIRKQFQSQFEKLVILDYIIRNTDRGNDNWLVKYDEMKYAKKIESEESNWIDNKQLLIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEETRNLILPYISDMNFVQDLCEDLYELFKTDKGFDRAAFENQMSVMRGQILNLTQALRDGKSPMQLAQMPCVIVECSKSGSQGRVVHLGSSFTQTVHCRKPFFSSW
phosphatidylinositol 4-kinase type 2-beta isoform 2
Refseq ID NP_083020
Protein GI 145966816
UniProt ID Q8CBQ5
mRNA ID NM_028744
Length 446
RefSeq Status VALIDATED
MAEACEPTRPSEDEDEEREPLLPRVAWAQPRRVAPGSAVRMQADEGADVLREPATDEPPAVSGEGSISASLSTELDRTRTTSSGPELCPFYSRSLCYKTTTALGYYNIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLLPNQGYLSEAGAYLVDVKLNLGIVPKTKVVWLVSETFNYSAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPKVGSFQLFVKDYKEAEYWLRRFEAEPLPENIRKQFQSQFEKLVILDYIIRNTDRGNDNWLVKYDEMKYAKKIESEESNWIDNKQLLIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEETRNLILPYISDMNFVQDLCEDLYELFKTDKGFDRAAFENQMSVMRGQILNLTQALRDGKSPMQLAQMPCVIVECSKSGSQGRVVHLGSSFTQTVHCRKPFFSSW

Gene Information

Entrez Gene ID
67073
Gene Name
phosphatidylinositol 4-kinase type 2 beta
Gene Symbol
Pi4k2b
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0004430 IEA:UniProtKB-EC F 1-phosphatidylinositol 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding

KEGG Pathway Links

KEGG Pathway ID Description
mmu00562 Inositol phosphate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5894013 Synthesis of PIPs at the early endosome membrane
5894009 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 4-kinase type 2 beta
Protein Entry
P4K2B_MOUSE
UniProt ID
Q8CBQ5
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8CBQ5-1; Sequence=Displayed; Name=2; IsoId=Q8CBQ5-2; Sequence=VSP_024828;
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Enzyme Regulation Recruited and activated by membrane association. Binding to the microsomal membrane has been shown to enhance its activity (By similarity). {ECO:0000250}.
Function Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking (By similarity). {ECO:0000250}.
Similarity Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. {ECO:0000305}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006583 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
145966899 RefSeq NP_080227 469 phosphatidylinositol 4-kinase type 2-beta isoform 1
145966816 RefSeq NP_083020 446 phosphatidylinositol 4-kinase type 2-beta isoform 2

Identical Sequences to LMP006583 proteins

Reference Database Accession Length Protein Name
GI:145966899 DBBJ BAC29091.1 469 unnamed protein product [Mus musculus]
GI:145966899 DBBJ BAE41986.1 469 unnamed protein product [Mus musculus]
GI:145966899 GenBank AAH62144.1 469 Phosphatidylinositol 4-kinase type 2 beta [Mus musculus]
GI:145966899 SwissProt Q8CBQ5.1 469 RecName: Full=Phosphatidylinositol 4-kinase type 2-beta; AltName: Full=Phosphatidylinositol 4-kinase type II-beta [Mus musculus]

Related Sequences to LMP006583 proteins

Reference Database Accession Length Protein Name
GI:145966899 DBBJ BAB27819.1 469 unnamed protein product [Mus musculus]
GI:145966816 DBBJ BAB30411.1 445 unnamed protein product [Mus musculus]
GI:145966816 DBBJ BAC29091.1 469 unnamed protein product [Mus musculus]
GI:145966899 GenBank AAL04155.1 469 type II phosphatidylinositol 4-kinase beta isoform [Mus musculus]
GI:145966816 GenBank AAN37399.1 445 phosphatidylinositol 4-kinase type 2 beta [Mus musculus]
GI:145966816 GenBank AAH62144.1 469 Phosphatidylinositol 4-kinase type 2 beta [Mus musculus]
GI:145966899 GenBank AAH83668.1 477 Phosphatidylinositol 4-kinase type 2 beta [Rattus norvegicus]
GI:145966899 GenBank EDL37661.1 469 phosphatidylinositol 4-kinase type 2 beta, isoform CRA_a [Mus musculus]
GI:145966816 GenBank EDL37662.1 446 phosphatidylinositol 4-kinase type 2 beta, isoform CRA_b [Mus musculus]
GI:145966899 RefSeq NP_001005883.1 477 phosphatidylinositol 4-kinase type 2-beta [Rattus norvegicus]
GI:145966816 SwissProt Q8CBQ5.1 469 RecName: Full=Phosphatidylinositol 4-kinase type 2-beta; AltName: Full=Phosphatidylinositol 4-kinase type II-beta [Mus musculus]
GI:145966899 SwissProt Q5XIL2.1 477 RecName: Full=Phosphatidylinositol 4-kinase type 2-beta; AltName: Full=Phosphatidylinositol 4-kinase type II-beta [Rattus norvegicus]