Gene/Proteome Database (LMPD)

LMPD ID
LMP006581
Gene ID
20216
Species
Mus musculus (Mouse)
Gene Name
acyl-CoA synthetase medium-chain family member 3
Gene Symbol
Acsm3
Synonyms
Sa; Sah
Alternate Names
acyl-coenzyme A synthetase ACSM3, mitochondrial; protein SA homolog; butyrate--CoA ligase 3; butyryl coenzyme A synthetase 3; butyryl-coenzyme A synthetase 3; SA hypertension-associated homolog; middle-chain acyl-CoA synthetase 3
Chromosome
7
Map Location
7|7 F3
EC Number
6.2.1.2

Proteins

acyl-coenzyme A synthetase ACSM3, mitochondrial
Refseq ID NP_997606
Protein GI 85810988
UniProt ID Q3UNX5
mRNA ID NM_212441
Length 580
RefSeq Status VALIDATED
MVMLLRARCFQRLAIPDPMRVLYKDYRTATPQNFSNYESMKQDFKIEIPEYFNFAKDVLDQWTNMEKAGKRLSNPAFWWIDGNGEELRWSFEELGLLSRKFANILTEACSLQRGDRVMVILPKIPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKAKCIITDDTLAPAVDAVAAKCENLHSKLIVSQHSREGWGNLKEMMKYASDSHTCVDTKHDEMMAIYFTSGTTGPPKMIGHTHSSFGLGLSVNGRFWLDLIASDVMWNTSDTGWAKSAWSSVFSPWTQGACVFAHYLPRFESTSILQTLSKFPITVFCSAPTAYRMLVQNDMSSYKFNSLKHCVSAGEPINPEVMEQWRKKTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFDVKILDENGATLPPGQEGDIALQVLPERPFGLFTHYVDNPSKTASTLRGSFYITGDRGYMDEDGYFWFVARSDDIILSSGYRIGPFEVESALIEHPSIAESAVVSSPDPIRGEVVKAFIVLNPDYKSHDQEQLKKEIQEHVKKTTAPYKYPRKVEFIEELPKTVSGKVKRNELRKKEWVTT
acyl-coenzyme A synthetase ACSM3, mitochondrial
Refseq ID NP_058566
Protein GI 85810990
UniProt ID Q3UNX5
mRNA ID NM_016870
Length 580
RefSeq Status VALIDATED
Protein sequence is identical to GI:85810988 (mRNA isoform)
acyl-coenzyme A synthetase ACSM3, mitochondrial
Refseq ID NP_997607
Protein GI 85810992
UniProt ID Q3UNX5
mRNA ID NM_212442
Length 580
RefSeq Status VALIDATED
Protein sequence is identical to GI:85810988 (mRNA isoform)
transit_peptide: 1..21 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q3UNX5.2) calculated_mol_wt: 2517 peptide sequence: MVMLLRARCFQRLAIPDPMRV mat_peptide: 22..580 product: Acyl-coenzyme A synthetase ACSM3, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q3UNX5.2) calculated_mol_wt: 63124 peptide sequence: LYKDYRTATPQNFSNYESMKQDFKIEIPEYFNFAKDVLDQWTNMEKAGKRLSNPAFWWIDGNGEELRWSFEELGLLSRKFANILTEACSLQRGDRVMVILPKIPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKAKCIITDDTLAPAVDAVAAKCENLHSKLIVSQHSREGWGNLKEMMKYASDSHTCVDTKHDEMMAIYFTSGTTGPPKMIGHTHSSFGLGLSVNGRFWLDLIASDVMWNTSDTGWAKSAWSSVFSPWTQGACVFAHYLPRFESTSILQTLSKFPITVFCSAPTAYRMLVQNDMSSYKFNSLKHCVSAGEPINPEVMEQWRKKTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFDVKILDENGATLPPGQEGDIALQVLPERPFGLFTHYVDNPSKTASTLRGSFYITGDRGYMDEDGYFWFVARSDDIILSSGYRIGPFEVESALIEHPSIAESAVVSSPDPIRGEVVKAFIVLNPDYKSHDQEQLKKEIQEHVKKTTAPYKYPRKVEFIEELPKTVSGKVKRNELRKKEWVTT transit_peptide: 1..21 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q3UNX5.2) calculated_mol_wt: 2517 peptide sequence: MVMLLRARCFQRLAIPDPMRV mat_peptide: 22..580 product: Acyl-coenzyme A synthetase ACSM3, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q3UNX5.2) calculated_mol_wt: 63124 peptide sequence: LYKDYRTATPQNFSNYESMKQDFKIEIPEYFNFAKDVLDQWTNMEKAGKRLSNPAFWWIDGNGEELRWSFEELGLLSRKFANILTEACSLQRGDRVMVILPKIPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKAKCIITDDTLAPAVDAVAAKCENLHSKLIVSQHSREGWGNLKEMMKYASDSHTCVDTKHDEMMAIYFTSGTTGPPKMIGHTHSSFGLGLSVNGRFWLDLIASDVMWNTSDTGWAKSAWSSVFSPWTQGACVFAHYLPRFESTSILQTLSKFPITVFCSAPTAYRMLVQNDMSSYKFNSLKHCVSAGEPINPEVMEQWRKKTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFDVKILDENGATLPPGQEGDIALQVLPERPFGLFTHYVDNPSKTASTLRGSFYITGDRGYMDEDGYFWFVARSDDIILSSGYRIGPFEVESALIEHPSIAESAVVSSPDPIRGEVVKAFIVLNPDYKSHDQEQLKKEIQEHVKKTTAPYKYPRKVEFIEELPKTVSGKVKRNELRKKEWVTT transit_peptide: 1..21 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q3UNX5.2) calculated_mol_wt: 2517 peptide sequence: MVMLLRARCFQRLAIPDPMRV mat_peptide: 22..580 product: Acyl-coenzyme A synthetase ACSM3, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q3UNX5.2) calculated_mol_wt: 63124 peptide sequence: LYKDYRTATPQNFSNYESMKQDFKIEIPEYFNFAKDVLDQWTNMEKAGKRLSNPAFWWIDGNGEELRWSFEELGLLSRKFANILTEACSLQRGDRVMVILPKIPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKAKCIITDDTLAPAVDAVAAKCENLHSKLIVSQHSREGWGNLKEMMKYASDSHTCVDTKHDEMMAIYFTSGTTGPPKMIGHTHSSFGLGLSVNGRFWLDLIASDVMWNTSDTGWAKSAWSSVFSPWTQGACVFAHYLPRFESTSILQTLSKFPITVFCSAPTAYRMLVQNDMSSYKFNSLKHCVSAGEPINPEVMEQWRKKTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFDVKILDENGATLPPGQEGDIALQVLPERPFGLFTHYVDNPSKTASTLRGSFYITGDRGYMDEDGYFWFVARSDDIILSSGYRIGPFEVESALIEHPSIAESAVVSSPDPIRGEVVKAFIVLNPDYKSHDQEQLKKEIQEHVKKTTAPYKYPRKVEFIEELPKTVSGKVKRNELRKKEWVTT

Gene Information

Entrez Gene ID
20216
Gene Name
acyl-CoA synthetase medium-chain family member 3
Gene Symbol
Acsm3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005759 IDA:MGI C mitochondrial matrix
GO:0005739 IDA:MGI C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0047760 IEA:UniProtKB-EC F butyrate-CoA ligase activity
GO:0015645 IDA:MGI F fatty acid ligase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006633 IDA:MGI P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
mmu00650 Butanoate metabolism
mmu01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase medium-chain family member 3
Protein Entry
ACSM3_MOUSE
UniProt ID
Q3UNX5
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UNX5-1; Sequence=Displayed; Name=2; IsoId=Q3UNX5-2; Sequence=VSP_028397; Note=No experimental confirmation available.;
Catalytic Activity ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Caution It is uncertain whether Met-1 or Met-3 is the initiator. {ECO:0000305}.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). {ECO:0000269|PubMed:11470804}.
Induction Up-regulated in kidney by androgens. Down-regulated in kidney by estrogens. Levels in kidney are very low in female C57BL/6 mice and in castrated male C57BL/6, 129/SvJ and BALB/c mice. Constitutively expressed in liver. {ECO:0000269|PubMed:15525578, ECO:0000269|PubMed:9449642}.
Sequence Caution Sequence=AAC79656.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH15248.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL40880.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA37141.1; Type=Frameshift; Positions=1, 63, 72; Evidence={ECO:0000305}; Sequence=BAE38232.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:11470804, ECO:0000269|PubMed:15525578}.
Tissue Specificity Detected in kidney (at protein level). Detected in kidney proximal tubules and in liver. Detected at low levels in testis, stomach, heart and lung. {ECO:0000269|PubMed:11470804, ECO:0000269|PubMed:15525578, ECO:0000269|PubMed:9449642, ECO:0000269|PubMed:9507200}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006581 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
85810988 RefSeq NP_997606 580 acyl-coenzyme A synthetase ACSM3, mitochondrial

Identical Sequences to LMP006581 proteins

Reference Database Accession Length Protein Name
GI:85810988 GenBank EDL17181.1 580 acyl-CoA synthetase medium-chain family member 3, isoform CRA_a [Mus musculus]
GI:85810988 RefSeq NP_058566.3 580 acyl-coenzyme A synthetase ACSM3, mitochondrial [Mus musculus]
GI:85810988 RefSeq NP_997607.2 580 acyl-coenzyme A synthetase ACSM3, mitochondrial [Mus musculus]
GI:85810988 SwissProt Q3UNX5.2 580 RecName: Full=Acyl-coenzyme A synthetase ACSM3, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 3; AltName: Full=Butyrate--CoA ligase 3; AltName: Full=Butyryl-coenzyme A synthetase 3; AltName: Full=Middle-chain acyl-CoA synthetase 3; AltName: Full=Protein SA homolog; Flags: Precursor [Mus musculus]

Related Sequences to LMP006581 proteins

Reference Database Accession Length Protein Name
GI:85810988 DBBJ BAE25622.1 622 unnamed protein product [Mus musculus]
GI:85810988 DBBJ BAE38232.1 578 unnamed protein product [Mus musculus]
GI:85810988 GenBank AAH15248.1 578 Acyl-CoA synthetase medium-chain family member 3 [Mus musculus]
GI:85810988 GenBank AAL40880.1 578 SA protein [Mus musculus]
GI:85810988 GenBank EDL17182.1 585 acyl-CoA synthetase medium-chain family member 3, isoform CRA_b, partial [Mus musculus]
GI:85810988 RefSeq XP_006507539.1 581 PREDICTED: acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X5 [Mus musculus]