Gene/Proteome Database (LMPD)

LMPD ID
LMP006552
Gene ID
94180
Species
Mus musculus (Mouse)
Gene Name
acyl-CoA synthetase bubblegum family member 1
Gene Symbol
Acsbg1
Synonyms
BG1; Bgm; E230019G03Rik; Lpd; R75185; mKIAA0631
Alternate Names
long-chain-fatty-acid--CoA ligase ACSBG1; mBG1; GR-LACS; bubblegum; lipidosin; lipodisin; lipidosis-related protein lipidosin; gonadotropin-regulated long chain acyl CoA synthetase
Chromosome
9
Map Location
9 A5.3|9
EC Number
6.2.1.3

Proteins

long-chain-fatty-acid--CoA ligase ACSBG1
Refseq ID NP_444408
Protein GI 16716465
UniProt ID Q99PU5
mRNA ID NM_053178
Length 721
RefSeq Status PROVISIONAL
MPRGSEAGYCCLSRDSNMPDSRDDQQQGASLGTSQDNSQTSSLIDGQTLSKESPSHGLELSAPEKARAASLDGAEEALWTTRADGRVRLRLEPFCTQRPYTVHQMFYEALDKYGNLSALGFKRKDKWERISYYQYYLIARKVAKGFLKLGLERAHSVAILGFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQYISHDCRANVIVVDTQKQLEKILKIWKDLPHLKAVVIYQEPPPKKMANVYTMEELIELGQEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIQPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFADPDALKGTLVNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPSNDLKPFTSRLADYLVLARVRQALGFAKCQKNFYGAAPMTAETQRFFLGLNIRLYAGYGLSESTGPHFMSSPYNYRLYSSGRVVPGCRVKLVNQDADGIGEICLWGRTIFMGYLNMEDKTCEAIDSEGWLHTGDMGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISSAMLIGDQRKFLSMLLTLKCTLDPETSEPTDSLTEQAVEFCQRVGSKASTVSEIVGQRDEAVYQAIHEGIQRVNANAAARPYHIQKWAILQRDFSISGGELGPTMKLKRLTVLEKYKDIIDSFYQEQKQ

Gene Information

Entrez Gene ID
94180
Gene Name
acyl-CoA synthetase bubblegum family member 1
Gene Symbol
Acsbg1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031410 IEA:UniProtKB-KW C cytoplasmic vesicle
GO:0043231 IEA:UniProtKB-KW C intracellular membrane-bounded organelle
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004467 ISS:HGNC F long-chain fatty acid-CoA ligase activity
GO:0031957 ISS:HGNC F very long-chain fatty acid-CoA ligase activity
GO:0001676 ISS:HGNC P long-chain fatty acid metabolic process
GO:0001552 IEA:Ensembl P ovarian follicle atresia
GO:0051384 IMP:MGI P response to glucocorticoid
GO:0000038 ISS:HGNC P very long-chain fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04920 Adipocytokine signaling pathway
mmu03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase bubblegum family member 1
Protein Entry
ACBG1_MOUSE
UniProt ID
Q99PU5
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. {ECO:0000269|PubMed:11112418, ECO:0000269|PubMed:14516277}.
Developmental Stage First detected on embryonic day 18 and increases steadily towards adulthood. {ECO:0000269|PubMed:14516277}.
Function Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (By similarity). {ECO:0000250}.
Sequence Caution Sequence=BAC97989.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}. Cytoplasmic vesicle. Microsome. Endoplasmic reticulum.
Tissue Specificity Mainly expressed in brain. Also expressed in adrenal gland and testis. In brain, it is present in cerebral cortical and cerebellar neurons and in steroidogenic cells of the adrenal gland, testis and ovary (at protein level). {ECO:0000269|PubMed:11112418, ECO:0000269|PubMed:12975357, ECO:0000269|PubMed:14516277, ECO:0000269|PubMed:16469493}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006552 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16716465 RefSeq NP_444408 721 long-chain-fatty-acid--CoA ligase ACSBG1

Identical Sequences to LMP006552 proteins

Reference Database Accession Length Protein Name
GI:16716465 DBBJ BAB32783.1 721 lipidosis-related protein Lipidosin [Mus musculus]
GI:16716465 DBBJ BAC35657.1 721 unnamed protein product [Mus musculus]
GI:16716465 GenBank AAH57322.1 721 Acyl-CoA synthetase bubblegum family member 1 [Mus musculus]
GI:16716465 GenBank AAY58226.1 721 gonadotropin-regulated long chain acyl CoA synthetase [Mus musculus]
GI:16716465 GenBank EDL25823.1 721 acyl-CoA synthetase bubblegum family member 1 [Mus musculus]
GI:16716465 SwissProt Q99PU5.1 721 RecName: Full=Long-chain-fatty-acid--CoA ligase ACSBG1; AltName: Full=Acyl-CoA synthetase bubblegum family member 1; Short=mBG1; AltName: Full=Gonadotropin-regulated long chain acyl CoA synthetase; Short=GR-LACS; AltName: Full=Lipidosin [Mus musculus]

Related Sequences to LMP006552 proteins

Reference Database Accession Length Protein Name
GI:16716465 DBBJ BAC97989.1 724 mKIAA0631 protein, partial [Mus musculus]
GI:16716465 EMBL CBF65080.1 721 unnamed protein product [Rattus norvegicus]
GI:16716465 EMBL CBU89951.1 721 unnamed protein product [Rattus norvegicus]
GI:16716465 GenBank AGX56980.1 721 Sequence 14279 from patent US 8541208
GI:16716465 RefSeq XP_006511652.1 754 PREDICTED: long-chain-fatty-acid--CoA ligase ACSBG1 isoform X2 [Mus musculus]
GI:16716465 SwissProt Q924N5.1 721 RecName: Full=Long-chain-fatty-acid--CoA ligase ACSBG1; AltName: Full=Acyl-CoA synthetase bubblegum family member 1; AltName: Full=Gonadotropin-regulated long chain acyl CoA synthetase; Short=GR-LACS [Rattus norvegicus]