Gene/Proteome Database (LMPD)

LMPD ID
LMP006446
Gene ID
56357
Species
Mus musculus (Mouse)
Gene Name
isovaleryl coenzyme A dehydrogenase
Gene Symbol
Ivd
Synonyms
1300016K07Rik; 6720455E18Rik; AI463340
Alternate Names
isovaleryl-CoA dehydrogenase, mitochondrial; isovaleryl dehydrogenase
Chromosome
2
Map Location
2 E4-E5|2
EC Number
1.3.8.4

Proteins

isovaleryl-CoA dehydrogenase, mitochondrial precursor
Refseq ID NP_062800
Protein GI 9789985
UniProt ID Q9JHI5
mRNA ID NM_019826
Length 424
RefSeq Status PROVISIONAL
MATAIRLLGRRVSSWRLRPSPSPLAVPRRAHSILPVDDDINGLNEEQKQLRHTISKFLQENLAPKAQEIDQTNDFKNLREFWKQLGSLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCVNQIVRNGNEAQKEKYLPKLISGEFIGALAMSEPNAGSDVVSMKLKAEKKGDHYVLNGNKFWITNGPDADILVVYAKTDLTAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELVFEDCKVPAANVLSQESKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGQFQLMQGKMADMYTRLMASRQYVYNVAKACDEGHIIPKDCAGVILYAAECATQVALDGIQCLGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFR
transit_peptide: 1..30 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9JHI5.1) calculated_mol_wt: 3372 peptide sequence: MATAIRLLGRRVSSWRLRPSPSPLAVPRRA mat_peptide: 31..424 product: Isovaleryl-CoA dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9JHI5.1) calculated_mol_wt: 42972 peptide sequence: HSILPVDDDINGLNEEQKQLRHTISKFLQENLAPKAQEIDQTNDFKNLREFWKQLGSLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCVNQIVRNGNEAQKEKYLPKLISGEFIGALAMSEPNAGSDVVSMKLKAEKKGDHYVLNGNKFWITNGPDADILVVYAKTDLTAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELVFEDCKVPAANVLSQESKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGQFQLMQGKMADMYTRLMASRQYVYNVAKACDEGHIIPKDCAGVILYAAECATQVALDGIQCLGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFR

Gene Information

Entrez Gene ID
56357
Gene Name
isovaleryl coenzyme A dehydrogenase
Gene Symbol
Ivd
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005759 IEA:Ensembl C mitochondrial matrix
GO:0031966 IEA:Ensembl C mitochondrial membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0008470 IEA:Ensembl F isovaleryl-CoA dehydrogenase activity
GO:0006552 IEA:UniProtKB-UniPathway P leucine catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-6 Leucine Catabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5892792 Branched-chain amino acid catabolism

Domain Information

InterPro Annotations

Accession Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain

UniProt Annotations

Entry Information

Gene Name
isovaleryl coenzyme A dehydrogenase
Protein Entry
IVD_MOUSE
UniProt ID
Q9JHI5
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Isovaleryl-CoA + electron-transfer flavoprotein = 3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Pathway Amino-acid degradation; L-leucine degradation; (S)-3- hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.
Ptm Acetylation of Lys-76 is observed in liver mitochondria from fasted mice but not from fed mice. {ECO:0000269|PubMed:23576753}.
Similarity Belongs to the acyl-CoA dehydrogenase family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix.
Subunit Homotetramer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006446 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9789985 RefSeq NP_062800 424 isovaleryl-CoA dehydrogenase, mitochondrial precursor

Identical Sequences to LMP006446 proteins

Reference Database Accession Length Protein Name
GI:9789985 GenBank AAF35888.1 424 isovaleryl dehydrogenase precursor [Mus musculus]
GI:9789985 GenBank AAF67667.1 424 isovaleryl CoA dehydrogenase [Mus musculus]
GI:9789985 GenBank AAH18325.1 424 Isovaleryl coenzyme A dehydrogenase [Mus musculus]
GI:9789985 GenBank AAH27198.1 424 Isovaleryl coenzyme A dehydrogenase [Mus musculus]
GI:9789985 GenBank EDL27929.1 424 isovaleryl coenzyme A dehydrogenase [Mus musculus]
GI:9789985 SwissProt Q9JHI5.1 424 RecName: Full=Isovaleryl-CoA dehydrogenase, mitochondrial; Short=IVD; Flags: Precursor [Mus musculus]

Related Sequences to LMP006446 proteins

Reference Database Accession Length Protein Name
GI:9789985 DBBJ BAB23751.1 424 unnamed protein product [Mus musculus]
GI:9789985 DBBJ BAB30859.1 424 unnamed protein product [Mus musculus]
GI:9789985 GenBank AAA41454.1 424 isovaleryl-CoA dehydrogenase precursor (EC 1.3.99.10) [Rattus norvegicus]
GI:9789985 GenBank AAH88401.1 424 Isovaleryl coenzyme A dehydrogenase [Rattus norvegicus]
GI:9789985 RefSeq NP_036724.1 424 isovaleryl-CoA dehydrogenase, mitochondrial precursor [Rattus norvegicus]
GI:9789985 SwissProt P12007.2 424 RecName: Full=Isovaleryl-CoA dehydrogenase, mitochondrial; Short=IVD; Flags: Precursor [Rattus norvegicus]