Gene/Proteome Database (LMPD)

LMPD ID
LMP006027
Gene ID
75678
Species
Mus musculus (Mouse)
Gene Name
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Gene Symbol
Ippk
Synonyms
1810043M15Rik; InsP6
Alternate Names
inositol-pentakisphosphate 2-kinase; insP5 2-kinase; ins(1,3,4,5,6)P5 2-kinase
Chromosome
13
Map Location
13 A5|13
EC Number
2.7.1.158

Proteins

inositol-pentakisphosphate 2-kinase isoform a
Refseq ID NP_951011
Protein GI 39979616
UniProt ID Q6P1C1
mRNA ID NM_199056
Length 489
RefSeq Status VALIDATED
MEEGKMDENEWSYHGEGNKSLVVAHAQRCVVLRFLKFPPNKKKTSEEILQHLQNIVDFGKNVMKDFLGENYVHCGEVVQLPLEFVKQLCLKIQCERPESRCDKDLDTFSGYAMCLPNLTRLQTFHFAEHRPILCVEIKPKCGFIPFSNDVTHEMKHKVCRYCMHQHLKVATGKWKKISKYCPLDLYSGNKQRMHFALRSLLQETQNNLRIFKNGELIYGCGDARSPVADLKELAHHLKPFFFPSNGLASGPHCTKAVIRELVHVITRVLLSSSEKARAGALRLGLQGPRVCEASPFSRSLHNQGKNTSEHSGLPKGCLLYKTLQVQMLDQLDIEGLYPLYKRVEQYLEEFPEERKTLQIDGPYDEVFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQGTSSDQRPVIPSSRSRLAFSVSVLDLDLKPYESIPHQYKLDSKIVNYYSKTVHAKDDTVRSTRFKEHEDCTLVLHKV

Gene Information

Entrez Gene ID
75678
Gene Name
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Gene Symbol
Ippk
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0035299 ISS:HGNC F inositol pentakisphosphate 2-kinase activity
GO:0052746 ISS:BHF-UCL P inositol phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
mmu00562 Inositol phosphate metabolism
mmu01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5894028 Synthesis of IPs in the nucleus
5894029 Synthesis of pyrophosphates in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR009286 Inositol-pentakisphosphate 2-kinase

UniProt Annotations

Entry Information

Gene Name
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Protein Entry
IPPK_MOUSE
UniProt ID
Q6P1C1
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.
Developmental Stage In E9 embryos it is expressed in regions corresponding to the neural tube, notochord and somites. Through the neural tube, it is expressed in the ventricular zone and in migrating neuroblasts. Also expressed in the notochord and specific regions of the somite. Strongly expressed in the myotome (future skeletal muscle) of the somite. In addition to the neural tube, it is also expressed in the ventricular zone and migrating neuroblasts throughout the embryonic brain. Prominent expression is detected in the yolk sac and embryonic heart. Within the yolk sac, it is expressed in both the epithelial and endothelial layers (blood vessels) but absent from the blood islands. In the heart, it is detected in both the atrial and ventricular chambers. In the ventricular myocardium it is present in both the endocardium and myocardium. Also expressed in the cardinal vein, aorta, digestive tract, and pharyngeal arches.
Disruption Phenotype Death during ermbryogenesis before 8.5 dpc, suggesting that InsP6 is required for yolk sac function and development. {ECO:0000269|PubMed:15939868}.
Domain The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Function Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:15939868}.
Similarity Belongs to the IPK1 type 2 family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity In brain, it is expressed throughout the hippocampus (CA1, CA2, CA3 and dentate gyrus), inner layers of the cerebral cortex, and Purkinje cells of the cerebellum. In heart, it is expressed in cardiomyocytes but not in interstitial cells, blood vessels, or valves. Also expressed in testis. {ECO:0000269|PubMed:15939868}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006027 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
39979616 RefSeq NP_951011 489 inositol-pentakisphosphate 2-kinase isoform a

Identical Sequences to LMP006027 proteins

Reference Database Accession Length Protein Name
GI:39979616 DBBJ BAE39551.1 489 unnamed protein product [Mus musculus]
GI:39979616 DBBJ BAE35623.1 489 unnamed protein product [Mus musculus]
GI:39979616 GenBank AAH62167.1 489 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Mus musculus]
GI:39979616 GenBank AAH65157.1 489 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Mus musculus]
GI:39979616 GenBank EDL41076.1 489 inositol 1,3,4,5,6-pentakisphosphate 2-kinase, isoform CRA_a [Mus musculus]
GI:39979616 SwissProt Q6P1C1.1 489 RecName: Full=Inositol-pentakisphosphate 2-kinase; AltName: Full=Inositol-1,3,4,5,6-pentakisphosphate 2-kinase; AltName: Full=Ins(1,3,4,5,6)P5 2-kinase; Short=InsP5 2-kinase [Mus musculus]

Related Sequences to LMP006027 proteins

Reference Database Accession Length Protein Name
GI:39979616 DBBJ BAE20447.1 489 unnamed protein product [Mus musculus]
GI:39979616 GenBank EGV99805.1 489 Inositol-pentakisphosphate 2-kinase [Cricetulus griseus]
GI:39979616 RefSeq NP_001008556.1 489 inositol-pentakisphosphate 2-kinase [Rattus norvegicus]
GI:39979616 RefSeq XP_003505388.1 489 PREDICTED: inositol-pentakisphosphate 2-kinase isoform X1 [Cricetulus griseus]
GI:39979616 RefSeq XP_006992344.1 489 PREDICTED: inositol-pentakisphosphate 2-kinase [Peromyscus maniculatus bairdii]
GI:39979616 SwissProt Q5PXE9.1 489 RecName: Full=Inositol-pentakisphosphate 2-kinase; AltName: Full=Inositol-1,3,4,5,6-pentakisphosphate 2-kinase; AltName: Full=Ins(1,3,4,5,6)P5 2-kinase; Short=InsP5 2-kinase; Short=rIPK1 [Rattus norvegicus]