Gene/Proteome Database (LMPD)

LMPD ID
LMP005942
Gene ID
225467
Species
Mus musculus (Mouse)
Gene Name
protein geranylgeranyltransferase type I, beta subunit
Gene Symbol
Pggt1b
Synonyms
2010207C17Rik; 2610100E13; AI451237; AI551093; BGG1; GGT1
Alternate Names
geranylgeranyl transferase type-1 subunit beta; GGTase-I-beta; geranylgeranyl transferase type I subunit beta; type I protein geranyl-geranyltransferase subunit beta
Chromosome
18
Map Location
18 C|18
EC Number
2.5.1.59

Proteins

geranylgeranyl transferase type-1 subunit beta
Refseq ID NP_766215
Protein GI 27369904
UniProt ID Q8BUY9
mRNA ID NM_172627
Length 377
RefSeq Status PROVISIONAL
MATTEDDRLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLSRCGFRGSSYLGIPFNPSKNPGAAHPYDSGHIAMTYTGLSCLIILGDDLGRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHIAT

Gene Information

Entrez Gene ID
225467
Gene Name
protein geranylgeranyltransferase type I, beta subunit
Gene Symbol
Pggt1b
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005953 ISS:UniProtKB C CAAX-protein geranylgeranyltransferase complex
GO:0004662 ISS:UniProtKB F CAAX-protein geranylgeranyltransferase activity
GO:0004661 ISS:UniProtKB F protein geranylgeranyltransferase activity
GO:0008270 ISS:UniProtKB F zinc ion binding
GO:0051771 IEA:Ensembl P negative regulation of nitric-oxide synthase biosynthetic process
GO:0045787 IEA:Ensembl P positive regulation of cell cycle
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation
GO:0018344 ISS:UniProtKB P protein geranylgeranylation
GO:0034097 IEA:Ensembl P response to cytokine

Domain Information

InterPro Annotations

Accession Description
IPR001330 Prenyltransferase/squalene oxidase
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

UniProt Annotations

Entry Information

Gene Name
protein geranylgeranyltransferase type I, beta subunit
Protein Entry
PGTB1_MOUSE
UniProt ID
Q8BUY9
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
Function Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (By similarity). {ECO:0000250}.
Similarity Belongs to the protein prenyltransferase subunit beta family. {ECO:0000305}.
Similarity Contains 4 PFTB repeats. {ECO:0000305}.
Subunit Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005942 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27369904 RefSeq NP_766215 377 geranylgeranyl transferase type-1 subunit beta

Identical Sequences to LMP005942 proteins

Reference Database Accession Length Protein Name
GI:27369904 DBBJ BAC38314.1 377 unnamed protein product [Mus musculus]
GI:27369904 GenBank EDL09986.1 377 protein geranylgeranyltransferase type I, beta subunit [Mus musculus]
GI:27369904 SwissProt Q8BUY9.1 377 RecName: Full=Geranylgeranyl transferase type-1 subunit beta; AltName: Full=Geranylgeranyl transferase type I subunit beta; Short=GGTase-I-beta; AltName: Full=Type I protein geranyl-geranyltransferase subunit beta [Mus musculus]

Related Sequences to LMP005942 proteins

Reference Database Accession Length Protein Name
GI:27369904 GenBank AAI41022.1 377 Protein geranylgeranyltransferase type I, beta subunit [Mus musculus]
GI:27369904 PDB 1S64 377 Chain D, Rat Protein Geranylgeranyltransferase Type-I Complexed With L-778,123 And A Sulfate Anion
GI:27369904 PDB 1S64 377 Chain F, Rat Protein Geranylgeranyltransferase Type-I Complexed With L-778,123 And A Sulfate Anion
GI:27369904 PDB 1S64 377 Chain H, Rat Protein Geranylgeranyltransferase Type-I Complexed With L-778,123 And A Sulfate Anion
GI:27369904 PDB 1S64 377 Chain J, Rat Protein Geranylgeranyltransferase Type-I Complexed With L-778,123 And A Sulfate Anion
GI:27369904 PDB 1S64 377 Chain L, Rat Protein Geranylgeranyltransferase Type-I Complexed With L-778,123 And A Sulfate Anion