Gene/Proteome Database (LMPD)

LMPD ID
LMP005840
Gene ID
222236
Species
Homo sapiens (Human)
Gene Name
N-acyl phosphatidylethanolamine phospholipase D
Gene Symbol
NAPEPLD
Synonyms
FMP30; NAPE-PLD
Alternate Names
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; NAPE-hydrolyzing phospholipase D
Chromosome
7
Map Location
7q22.1
EC Number
3.1.4.54
Summary
NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]
Orthologs
View orthologs and multiple alignments for NAPEPLD

Proteins

N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Refseq ID NP_945341
Protein GI 170932481
UniProt ID Q6IQ20
mRNA ID NM_198990
Length 393
RefSeq Status VALIDATED
MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEELDKELPVLKPYFITNPEEAGVREAGLRVTWLGHATVMVEMDELIFLTDPIFSSRASPSQYMGPKRFRRSPCTISELPPIDAVLISHNHYDHLDYNSVIALNERFGNELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLEPPVKLNEALERYGLNAEDFFVLKHGESRYLNNDDENF
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Refseq ID NP_001116310
Protein GI 170932483
UniProt ID Q6IQ20
mRNA ID NM_001122838
Length 393
RefSeq Status VALIDATED
Protein sequence is identical to GI:170932481 (mRNA isoform)

Gene Information

Entrez Gene ID
222236
Gene Name
N-acyl phosphatidylethanolamine phospholipase D
Gene Symbol
NAPEPLD
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0042622 TAS:Reactome C photoreceptor outer segment membrane
GO:0070290 IEA:InterPro F N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0009395 IEA:UniProtKB-KW P phospholipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04723 Retrograde endocannabinoid signaling

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160194 Biosynthesis of A2E, implicated in retinal degradation
REACT_160156 The canonical retinoid cycle in rods (twilight vision)
REACT_160125 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR001279 Beta-lactamase-like
IPR024884 N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D

UniProt Annotations

Entry Information

Gene Name
N-acyl phosphatidylethanolamine phospholipase D
Protein Entry
NAPEP_HUMAN
UniProt ID
Q6IQ20
Species
Human

Comments

Comment Type Description
Catalytic Activity An N-acylphosphatidylethanolamine + H(2)O = an N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate.
Cofactor Name=Zn(2+); Xref=ChEBI
Enzyme Regulation Activity is stimulated by divalent cations.
Function Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity).
Similarity Belongs to the NAPE-PLD family.
Subcellular Location Membrane .
Subunit Monomer.
Web Resource Name=Wikipedia; Note=N-acyl phosphatidylethanolamine-specific phospholipase D entry; URL="http://en.wikipedia.org/wiki/N-acyl_phosphatidylethanolamine-specific_phospholipase_D";

Identical and Related Proteins

Unique RefSeq proteins for LMP005840 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
170932481 RefSeq NP_945341 393 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

Identical Sequences to LMP005840 proteins

Reference Database Accession Length Protein Name
GI:170932481 RefSeq XP_005250274.1 393 PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X4 [Homo sapiens]
GI:170932481 RefSeq XP_005250275.1 393 PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X5 [Homo sapiens]
GI:170932481 RefSeq XP_006715962.1 393 PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X6 [Homo sapiens]
GI:170932481 RefSeq XP_006725117.1 393 PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X6 [Homo sapiens]
GI:170932481 RefSeq XP_006725118.1 393 PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X7 [Homo sapiens]
GI:170932481 RefSeq XP_006725119.1 393 PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X8 [Homo sapiens]

Related Sequences to LMP005840 proteins

Reference Database Accession Length Protein Name
GI:170932481 GenBank AAH71604.1 393 N-acyl phosphatidylethanolamine phospholipase D [Homo sapiens]
GI:170932481 GenBank EAW83314.1 393 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, isoform CRA_a [Homo sapiens]
GI:170932481 GenBank EAW83315.1 393 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, isoform CRA_a [Homo sapiens]
GI:170932481 RefSeq XP_005250271.1 466 PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1 [Homo sapiens]
GI:170932481 RefSeq XP_006725115.1 466 PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X4 [Homo sapiens]
GI:170932481 RefSeq XP_006725116.1 466 PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X5 [Homo sapiens]