Gene/Proteome Database (LMPD)

LMPD ID
LMP005663
Gene ID
51201
Species
Homo sapiens (Human)
Gene Name
zinc finger, DHHC-type containing 2
Gene Symbol
ZDHHC2
Synonyms
DHHC2; ZNF372
Alternate Names
palmitoyltransferase ZDHHC2; rec; ream; DHHC-2; zinc finger protein 372; reduced expression in cancer protein; zinc finger, DHHC domain containing 2; zinc finger DHHC domain-containing protein 2; reduced expression associated with metastasis protein
Chromosome
8
Map Location
8p22
EC Number
2.3.1.225

Proteins

palmitoyltransferase ZDHHC2
Refseq ID NP_057437
Protein GI 7705949
UniProt ID Q9UIJ5
mRNA ID NM_016353
Length 367
RefSeq Status VALIDATED
MAPSGPGSSARRRCRRVLYWIPVVFITLLLGWSYYAYAIQLCIVSMENTGEQVVCLMAYHLLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKDLLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYCDRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCLFIAATDLQYFIKFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNKSTLEAFRSPVFRHGTDKNGFSLGFSKNMRQVFGDEKKYWLLPIFSSLGDGCSFPTCLVNQDPEQASTPAGLNSTAKNLENHQFPAKPLRESQSHLLTDSQSWTESSINPGKCKAGMSNPALTMENET

Gene Information

Entrez Gene ID
51201
Gene Name
zinc finger, DHHC-type containing 2
Gene Symbol
ZDHHC2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:UniProt C Golgi apparatus
GO:0005783 IDA:UniProt C endoplasmic reticulum
GO:0005887 IEA:Ensembl C integral component of plasma membrane
GO:0055038 IEA:Ensembl C recycling endosome membrane
GO:0016409 IDA:UniProt F palmitoyltransferase activity
GO:0019706 IEA:UniProtKB-EC F protein-cysteine S-palmitoyltransferase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0018345 IDA:UniProt P protein palmitoylation

Domain Information

InterPro Annotations

Accession Description
IPR001594 Zinc finger, DHHC-type, palmitoyltransferase

UniProt Annotations

Entry Information

Gene Name
zinc finger, DHHC-type containing 2
Protein Entry
ZDHC2_HUMAN
UniProt ID
Q9UIJ5
Species
Human

Comments

Comment Type Description
Catalytic Activity Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
Disease Note=Mutations in ZDHHC2 are found in hepatocellular carcinoma and colorectal cancer.
Domain The DHHC domain is required for palmitoyltransferase activity.
Function Palmitoyltransferase specific for GAP43 and DLG4/PSD95.
Similarity Belongs to the DHHC palmitoyltransferase family.
Similarity Contains 1 DHHC-type zinc finger.
Subcellular Location Membrane ; Multi-pass membrane protein .
Tissue Specificity Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis.

Identical and Related Proteins

Unique RefSeq proteins for LMP005663 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7705949 RefSeq NP_057437 367 palmitoyltransferase ZDHHC2

Identical Sequences to LMP005663 proteins

Reference Database Accession Length Protein Name
GI:7705949 GenBank JAA19969.1 367 zinc finger, DHHC-type containing 2 [Pan troglodytes]
GI:7705949 GenBank JAA24266.1 367 zinc finger, DHHC-type containing 2 [Pan troglodytes]
GI:7705949 GenBank AGJ46247.1 367 Sequence 2 from patent US 8404655
GI:7705949 GenBank AHD77800.1 367 Sequence 23929 from patent US 8586006
GI:7705949 RefSeq XP_519614.3 367 PREDICTED: palmitoyltransferase ZDHHC2 [Pan troglodytes]
GI:7705949 RefSeq XP_004046739.1 367 PREDICTED: palmitoyltransferase ZDHHC2 [Gorilla gorilla gorilla]

Related Sequences to LMP005663 proteins

Reference Database Accession Length Protein Name
GI:7705949 GenBank AFI35107.1 367 palmitoyltransferase ZDHHC2 [Macaca mulatta]
GI:7705949 GenBank JAA07359.1 367 zinc finger, DHHC-type containing 2 [Pan troglodytes]
GI:7705949 GenBank AIC62158.1 367 ZDHHC2, partial [synthetic construct]
GI:7705949 RefSeq XP_002818881.1 367 PREDICTED: palmitoyltransferase ZDHHC2 [Pongo abelii]
GI:7705949 RefSeq XP_003256751.1 367 PREDICTED: palmitoyltransferase ZDHHC2 [Nomascus leucogenys]
GI:7705949 RefSeq XP_009241831.1 367 PREDICTED: palmitoyltransferase ZDHHC2 [Pongo abelii]