Gene/Proteome Database (LMPD)

LMPD ID
LMP005573
Gene ID
27413
Species
Mus musculus (Mouse)
Gene Name
ATP-binding cassette, sub-family B (MDR/TAP), member 11
Gene Symbol
Abcb11
Synonyms
ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP
Alternate Names
bile salt export pump; sister of P-glycoprotein; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B, member 11
Chromosome
2
Map Location
2 C2|2 39.69 cM
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for Abcb11

Proteins

bile salt export pump
Refseq ID NP_066302
Protein GI 120432047
UniProt ID Q9QY30
mRNA ID NM_021022
Length 1321
RefSeq Status REVIEWED
MSDSVILRSVKKFGEENHAFESDGFHNNDKKSRLQDKKKGEGARVGFFELFRFSSSKDNWLMFMGSVCALLHGMAQPGMIIVFGILTDIFVEYDIERQELSIPEKVCMNNTIVWINSSFNQNMTNGTSCGLVDINSEVIKFSGIYAGVGVAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDCTSVGELNSRFSDDINKIDEAIADQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTIDRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGREEATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDMATSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLERKGVYFMLVTLQSQEDNTHKETGIKGKDTTEGDTPERTFSRGSYQDSLRASIRQRSKSQLSHLSHEPPLAIGDHKSSYEDRKDNDVLVEEVEPAPVRRILKYNISEWPYILVGALCAAINGAVTPIYSLLFSQILKTFSLVDKEQQRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFLFNWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEALSNIRTVAGIGVEGRFIKAFEVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDLNFSYVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVYSGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTHKKLMDQKGAYYKLVITGAPIS

Gene Information

Entrez Gene ID
27413
Gene Name
ATP-binding cassette, sub-family B (MDR/TAP), member 11
Gene Symbol
Abcb11
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0045177 IDA:MGI C apical part of cell
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016021 IBA:RefGenome C integral component of membrane
GO:0046581 IDA:MGI C intercellular canaliculus
GO:0016020 IDA:MGI C membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0042626 IBA:RefGenome F ATPase activity, coupled to transmembrane movement of substances
GO:0015126 IBA:RefGenome F canalicular bile acid transmembrane transporter activity
GO:0015722 IBA:RefGenome P canalicular bile acid transport
GO:0055085 IBA:RefGenome P transmembrane transport

KEGG Pathway Links

KEGG Pathway ID Description
mmu02010 ABC transporters
mmu04976 Bile secretion

REACTOME Pathway Links

REACTOME Pathway ID Description
5893229 Recycling of bile acids and salts

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR017871 ABC transporter, conserved site
IPR003439 ABC_transporter-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
ATP-binding cassette, sub-family B (MDR/TAP), member 11
Protein Entry
ABCBB_MOUSE
UniProt ID
Q9QY30
Species
Mouse

Comments

Comment Type Description
Domain Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
Function Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Similarity Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
Similarity Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00441}.
Similarity Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular Location Membrane; Multi-pass membrane protein.
Subunit Interacts with HAX1. {ECO:0000250}.
Tissue Specificity Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Identical and Related Proteins

Unique RefSeq proteins for LMP005573 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
120432047 RefSeq NP_066302 1321 bile salt export pump

Identical Sequences to LMP005573 proteins

Reference Database Accession Length Protein Name
GI:120432047 GenBank EDL27032.1 1321 ATP-binding cassette, sub-family B (MDR/TAP), member 11 [Mus musculus]
GI:120432047 GenBank AAI56053.1 1321 ATP-binding cassette, sub-family B (MDR/TAP), member 11, partial [synthetic construct]
GI:120432047 GenBank AAI72671.1 1321 ATP-binding cassette, sub-family B (MDR/TAP), member 11 [synthetic construct]
GI:120432047 RefSeq XP_006499732.1 1321 PREDICTED: bile salt export pump isoform X1 [Mus musculus]
GI:120432047 SwissProt Q9QY30.2 1321 RecName: Full=Bile salt export pump; AltName: Full=ATP-binding cassette sub-family B member 11; AltName: Full=Sister of P-glycoprotein [Mus musculus]

Related Sequences to LMP005573 proteins

Reference Database Accession Length Protein Name
GI:120432047 GenBank AAC40084.1 1321 bile salt export pump [Rattus norvegicus]
GI:120432047 GenBank AAC24753.1 1321 P-glycoprotein sister [Rattus norvegicus]
GI:120432047 GenBank AAF14372.1 1321 liver bile salt export pump [Mus musculus domesticus]
GI:120432047 RefSeq NP_113948.1 1321 bile salt export pump [Rattus norvegicus]
GI:120432047 RefSeq XP_006972445.1 1319 PREDICTED: bile salt export pump [Peromyscus maniculatus bairdii]
GI:120432047 SwissProt O70127.1 1321 RecName: Full=Bile salt export pump; AltName: Full=ATP-binding cassette sub-family B member 11; AltName: Full=Sister of P-glycoprotein [Rattus norvegicus]